Physiologically acceptable aqueous solutions and methods for their use

a technology of aqueous solutions and physiologically acceptable solutions, applied in the field ofplasmalike solutions, can solve the problem that no single solution has proved suitable for use in all potential applications

Inactive Publication Date: 2004-05-06
SEGALL PAUL E +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although synthetic plasma-like solutions have found increasing use in a variety of a...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Solution Compositions

[0057] A. Composition of L solution. The composition of L solution is as follows: Na.sup.+143 mM; Ca.sup.++2.5 mM; Mg.sup.++0.45 mM; K.sup.+ mM 3.0; Cl.sup.-124 mM; glucose 5 mM; and lactate 28 mM. The solution is filtered to remove undissolved material and placed in autoclavable containers and heated in an autoclave to a temperature of 120.degree. C. for 15 minutes.

[0058] B. Composition of HL (BioTime Hextend.TM.-lactate) Solution. L formulation with the addition of 60 g / l of high molecular weight Hetastarch.

[0059] C. Composition of HLB (BioTime Hextend.TM.-lactate-bicarbonate) Solution. HL solution with the addition of 5 ml / l 1 M solution of NaHCO.sub.3.

[0060] D. Composition of HL-DL (BioTime Hetadex.TM.-lactate) Solution. HL formulation except 6% Dextran 40 is used in place of 6% Hetastarch.

[0061] E. Composition of AL (BioTime Albextend.TM.) Solution. L solution except with the addition of 50 g / l albumin. ALB solution is AL solution with the addition of 5 ml / ...

example 2

Blood Replacement with HL-DL Solution.

[0064] A 240 g female rat was anesthetized with ketamine, xylazine an acepromazine mixture injected i.m. The animal was placed on a stage and its right femoral artery and vein cannulated. The animal was perfused isovolemically with 10 ml of HL-DL solution until its hematocrit reached 17.2%. The cannulas were removed, vessels ligated, and the incision closed. The animal tolerated perfusion well, and was active and eating within 3 days of the procedure. The animal recovered fully and remained alive and healthy.

example 3

Reviving An Ice-Cold Blood-Substituted Dog.

[0065] A 26.8 kg male dog was anesthetized with nembutal and intubated. It was moved to the operating room, ventilated, and catheterized with venous, Foley, arterial, and Swan-Ganz catheters, and after i.v. heparin, its right femoral artery and vein were cannulated. An esophageal tube was inserted and antacid administered. Temperature sensors were placed in the esophagus and the rectum. Methyl prednisolone was injected i.v.

[0066] The animal was wrapped in a cooling blanket, and surface cooling initiated. The animal's cannulas were connected to a bypass circuit, which consisted of a vortex blood pump, an oxygenator with a built-in heat exchanger, a secondary in-line heat exchanger, and a funnel for the rapid administration of blood and blood substitute. Whole blood (225 ml) was removed from the dog and saved for rewarming. Blood volume was quickly replaced with HLB solution. The bypass circuit containing 1.05 liters of HLB solution was opene...

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Abstract

Artificial plasma-like solutions and methods for their use are provided. The subject solutions include: electrolytes and an oncotic agent. The subject solutions find use in a variety of applications, particularly in those applications where at least a portion of a host's blood volume is replaced with a blood substitute.

Description

[0001] This application is a continuation of application Ser. No. 09 / 530,006 filed as Application No. PCT / US97 / 19964 on Oct. 31, 1997; which application is a continuation-in-part of U.S. application Ser. No. 08 / 886,921 filed Jul. 2, 1997 and now abandoned; which application is a continuation of U.S. application Ser. No. 08 / 780,974 filed Jan. 9, 1997 and now abandoned; which application is a continuation of U.S. application Ser. No. 08 / 364,699 filed Dec. 28, 1994 and now abandoned; which application is a continuation-in-part of U.S. application Ser. No. 08 / 253,384 filed Jun. 3, 1994 and now issued as U.S. Pat. No. 5,702,880; which application is a continuation-in-part of U.S. application Ser. No. 08 / 133,527 filed Oct. 7, 1993 and now abandoned; which application is a continuation-in-part of U.S. application Ser. No. 08 / 071,533 filed Jun. 4, 1993 and now issued as U.S. Pat. No. 5,407,428; the disclosures of which are herein incorporated by reference.[0002] 1. Technical Field[0003] The...

Claims

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Application Information

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IPC IPC(8): A01N1/02A61K9/00A61K33/10A61K33/14A61K38/36A61K38/38A61K38/42A61K45/06
CPCA01N1/02A01N1/0205A61K45/06A61K38/42A61K38/38A61K38/36A61K33/14A61K33/10A61K9/0026A01N1/0221A61K2300/00
Inventor SEGALL, PAUL E.STERNBERG, HALWAITZ, HAROLD D.SEGALL, JUDITH M.
Owner SEGALL PAUL E
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