Compositions and methods for treatment of neurological disorders

US20050014779A1Inactive Publication Date: 2005-01-20FLORIDA UNIV OF A FLORIDA
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
FLORIDA UNIV OF A FLORIDA
Publication Date
2005-01-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention concerns methods for treating or preventing neurological disorders characterized by dysfunction of nicotine acetylcholine receptors by co-administration of metanicotine and at least one compound which exhibits antagonist activity, or both agonistic and antagonist activity, toward one or more nicotinic acetylcholine receptor subtypes. The subject invention, in another aspect, pertains to pharmaceutical compositions containing metanicotine and at least one compound which exhibits antagonistic activity, or both agonistic and antagonistic activity, toward one or more nicotinic acetylcholine receptor subtypes.
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Description

CROSS-REFERENCE TO RELATED APPLICATION

[0001] The present application is a continuation of U.S. application Ser. No. 10 / 036,988, filed Dec. 31, 2001, which is hereby incorporated by reference herein in its entirety, including any figures, tables, nucleic acid sequences, amino acid sequences, or drawings.GOVERNMENT SUPPORT

[0002] The subject invention was made with government support under a research project supported by National Institutes of Health Grant No. PO1 AG10485. The government has certain rights in this invention.BACKGROUND OF THE INVENTION

[0003] The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The ion channel is formed from the assembly of a membrane protein oligomer (a pentamer) that binds the neurotransmitter, acetylcholine, its natural ligand. The nAChR also binds agonists, such as nicotine, and nicotinic antagonists, such as mecamylamine. The binding of two mole...

Claims

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