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Methods and compositions comprising monitoring devices

a technology of monitoring device and composition, which is applied in the direction of ict adaptation, diagnostic recording/measuring, instruments, etc., can solve the problems of high sensitive detection methods, easy administration, and non-invasive effects

Inactive Publication Date: 2005-02-10
GRYCZYNSKI ZYGMUNT +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

Unlike prior art detection methods, the detection methods provided herein are highly sensitive, easily administered and non-invasive. Most importantly, the detection methods are especially effective in transdermal detection of fluorescent signals, thereby eliminating the need for involved chemical analysis of bodily fluids, supervision by healthcare workers, or use of dangerous tracer substances such as radioactive labels.
A further object of the present invention to provide compositions and methods useful for monitoring therapeutic compliance in patients in order to improve physician patient communication.

Problems solved by technology

Unlike prior art detection methods, the detection methods provided herein are highly sensitive, easily administered and non-invasive.

Method used

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  • Methods and compositions comprising monitoring devices
  • Methods and compositions comprising monitoring devices
  • Methods and compositions comprising monitoring devices

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The following experiment was conducted in order to measure the presence and concentration of fluorophores in scattering media, including intralipid suspensions, chicken skin and chicken muscle. The fluorophores were rhodamine 800 (Rh800) and indocyanine green (IcG), both of which would be excited at long wavelengths not absorbed by tissues. It is known to be difficult to quantify the fluorescence intensity from probes in scattering media. This problem was solved using modulated excitation near 2 MHz and a long lifetime reference fluorophores in a polymer film placed immediately on the illuminated surface of the sample. Under these conditions, the modulation of the emission is a measure of the intensity of the fluorophore (Rh800 or IcG) relative to the long lifetime reference. Using this method we were able to measure the concentration dependent intensities of Rh800 and IcG in an intralipid suspension. Additionally, micromolar concentrations of these probes could be detected in chic...

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Abstract

Methods and compositions for the detection and monitoring of drug therapy are provided. In particular, efficient and sensitive methods for the detection of drug ingestion are provided for determining whether individuals are complying with prescribed therapeutic regimens, and for providing a mechanism for identifying drug-resistant strains of infectious agents. The claimed methods and compositions involve the application of transdermal devices containing detection mechanisms for receiving and recording signals generated by the ingestion of a labeled drug. Such devices are attached to the skin for the duration of drug therapy and compliance is determined either by direct reading, or by remote monitoring whereby signals are transmitted from the device and received at an external site such as a healthcare facility.

Description

FIELD OF INVENTION The present invention relates to methods and compositions for monitoring devices useful for determining whether patients have complied with prescribed therapeutic regimens. In particular, the detection devices of the present invention comprise instruments that may be placed on a patient's skin for transdermal detection of a signal, such as a fluorescent signal, for indicating positive or negative compliance. BACKGROUND OF THE INVENTION Nonadherence to therapy has been cited as one of the greatest obstacles to the elimination of certain infectious diseases such as tuberculosis (TB). Nonadherence results in treatment failure, relapse, continued infectiousness, and is one of the principal “drivers” for the emergence of drug-resistant strains of infectious agents. Although numerous systems and procedures have been suggested and implemented in an attempt to improve drug therapy compliance, there remains a need for a system that is easily administered and simple to u...

Claims

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Application Information

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IPC IPC(8): A61K49/00G06F19/00
CPCA61K49/0034A61K49/0041G06F19/3456A61K49/0082A61K49/0063A61B5/0071A61B5/4833A61B5/681G16H40/63G16H20/10Y02A90/10
Inventor GRYCZYNSKI, ZYGMUNTMCCOMBS, CANDACELAKOWICZ, JOSEPH R.ABUGO, OMOEFE
Owner GRYCZYNSKI ZYGMUNT
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