Chemically modified biological molecules and methods for coupling biological molecules to solid support

a biological and chemical modification technology, applied in the field of compounds, can solve the problems of net positive electrostatic charge on the glass surface, rusty investigation, and activated derivatization, and achieve the effects of easy derivatization, high detection sensitivity, and quick reaction ra
US20050064494A1Inactive Publication Date: 2005-03-24BAYLOR COLLEGE OF MEDICINE
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
BAYLOR COLLEGE OF MEDICINE
Publication Date
2005-03-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to novel chemically modified biological molecules with enhanced lability towards solid supports, such as glass. These modified molecules can be readily affixed to solid supports, for instance, a glass surface, without first derivatizing the glass surface. High-density microarrays based on these modified molecules as well as methods for preparing these microarrays are also useful.
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Description

FIELD OF THE INVENTION The present invention claims a closely related family of compounds, devices, and methods relating to techniques for immobilizing biological molecules to a solid support for the purpose of conducting scientific investigation or routine testing upon the bound molecule samples in areas such as genome-wide genetic mapping and gene expression studies, protein interaction studies, peptide interaction studies & small molecule interactions with larger macromolecules. BACKGROUND OF THE INVENTION A large percentage of investigation in the biochemical arts are directed to studies involving nucleic acids, particularly deoxyribonucleic acid, or DNA. DNA is a water-soluble compound, that if left in solution (i.e., a water-based solution), is likely to degrade, through hydrolysis, and so forth. Obviously this frustrates any investigation involving DNA, and so therefore, accurate and reliable study involving DNA requires a method or device to ensure the integrity of DNA. To...

Claims

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