Drug complex for treatment of metastatic prostate cancer

a prostate cancer and drug complex technology, applied in the direction of drug compositions, antibody medical ingredients, peptide/protein ingredients, etc., can solve the problem of limited number of treatments available, and achieve the effect of lowering toxicity and high efficacy
US20050233948A1Inactive Publication Date: 2005-10-20BETH ISRAEL DEACONESS MEDICAL CENT INC +2
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
BETH ISRAEL DEACONESS MEDICAL CENT INC
Publication Date
2005-10-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

A drug complex for delivery of a drug or other agent to a target cell, comprising a targeting carrier molecule which is selectively distributed to a specific cell type or tissue containing the specific cell type; a linker which is acted upon by a molecule which is present at an effective concentration in the environs of the specific cell type; and a drug or an agent to be delivered to the specific cell type. In particular, a drug complex for delivering a cytotoxic drug to prostate cancer cells, comprising a targeting carrier molecule which is selectively delivered to prostate tissue, bone or both; a peptide which is a substrate for prostate specific antigen; and a cytotoxic drug which is toxic to androgen independent prostate cancer cells.
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Description

RELATED APPLICATION

[0001] This application is a divisional application of U.S. application Ser. No. 10 / 119,417 filed Apr. 9, 2002, which is a divisional application of U.S. application Ser. No. 09 / 110,822 filed Jul. 6, 1998 (now U.S. Pat. No. 6,368,598), which is a continuation-in-part of application Ser. No. 09 / 003,838 filed Jan. 7, 1998, now abandoned, which is a continuation of application Ser. No. 08 / 713,114 filed Sep. 16, 1996, now abandoned. The entire teachings of these applications are incorporated herein by reference.BACKGROUND OF THE INVENTION

[0002] Prostate cancer is the second most common malignancy in men and is the third most common cause of cancer death in men older than age 55. Harrison's Principles of Internal Medicine, Eds. J. D. Wilson et al., 11th Edition, pp. 1630-1633, McGraw Hill, New York, 1991. New methods of identifying and treating prostate cancer early are extremely important in saving the lives of those afflicted. Presently, only a limited number of tr...

Claims

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