Biomaterial for suturing

Abstract

A biomaterial for suturing comprising a physiologically compatible support material coated with a cellular population with proliferative and / or differentiation capacity, characteristics which facilitate the regeneration of the sutured tissue. This biomaterial for suturing not only brings together the two edges of an open wound, but also contributes actively to the healing process, thereby accelerating the tissue repair process. Also disclosed are methods for making the biomaterial and methods for using the biomaterials in therapy.

Description

[0001] This invention refers to a material for suturing and its applications. More specifically, the invention refers to a material for suturing covered with cells that contribute in a biologically active way to the tissue repair process and therefore the healing of wounds. BACKGROUND OF THE INVENTION [0002] Any open wound poses the risk of infection and a channel for air and organic fluids to escape, making its closure an urgent necessity. In superficial skin wounds that do not pierce the dermis, spontaneous closure takes place when the edges of the wound come together, while in wounds where there is a clear separation of tissues only surgical action (suturing of the wound) can achieve this primary closure, also known as primary intention healing. [0003] Traditionally, the suture has been the classical method for bringing the edges of the wound together in order to achieve the rapid tissue repair. Primary intention healing by suturing consists of bringing the edges of the wound tog...

AI Technical Summary

Benefits of technology

This patent is about a new material for suturing and repairing wounds that is biologically active and helps improve the healing process. The material is made up of cells that contribute to the tissue repair process. This new material can be used in traditional suturing or stapling to close wounds, and it has several advantages over traditional methods. First, it helps to close wounds faster, reducing the risk of infection. Second, it helps to prevent leakage of fluids and air. Third, it reduces the need for additional adhesive materials that may cause inflammation or delay the healing process. Fourth, it can be used on internal tissue without inducing an inflammatory response. Fifth, it can be coated with antioxidants and other substances to prevent contamination and promote healing. Overall, this new material for suturing and repairing wounds is more effective and safer than traditional methods.

Problems solved by technology

Any open wound poses the risk of infection and a channel for air and organic fluids to escape, making its closure an urgent necessity.

In some situations, these sutures are particularly delicate due to the healing difficulties of the tissues they are used on.

One of the biggest disadvantages of sutures is the fact that the diameter of the needle is larger than that of the thread, so that the point where the needle is inserted is not taken up completely by the thread, thus generating areas where fluids can escape.

This deficient closure of the wound is frequently the cause of post-operative complications, such as in the case of intestinal anastomosis in patients with carcinoma or diverticulosis who have had part of their intestine removed, after which the two healthy ends are joined together.

In these patients, when the closure is incomplete faecal matter can leak into the surrounding tissues, which is a cause of peritonitis and places the patient's life at risk.

A limiting factor in the use of staples as a method of primary intention healing is the need to have access to the upper and lower part of the tissues being joined together.

Furthermore, the force exerted when inserting the staples may cause the tissue to tear.

The biggest disadvantage of biological adhesives is the risk of viral transmission.

Moreover, there are several disadvantages to the synthetic bioadhesives currently available.

Most of them come in liquid form and are therefore difficult to apply, so they are used primarily on superficial wounds.

They are also allergenic and potentially toxic substances.

It has been described that these materials induce an inflammatory response in the body, which contributes to a delay in the regeneration and healing of the tissue, thus greatly limiting their usefulness (Aronson et al., 1970; Milde et al., 1989).

However, one of the disadvantages is the allergenic nature and potential toxicity of bioadhesives.

The ability to join biological tissues together has been one of the principal challenges of biomedical research.

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