Multi-reservoir device for controlled drug delivery

a multi-reservoir device and controlled drug technology, applied in the direction of medical devices, inorganic non-active ingredients, therapy, etc., can solve the problems of clogging, failure of the pump, and the individual's clogging may be catastrophic, and depend on the reliable operation of moving parts

Inactive Publication Date: 2006-08-24
MASSACHUSETTS INST OF TECH
View PDF98 Cites 17 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, all of these methods have unique disadvantages when considering the treatment of a chronic condition.
A major disadvantage of both external and internal micropumps is that they depend on the reliable operation of moving parts.
Failure of the pump due to breakage, leakage, or clogging may be catastrophic for the individual.
Tablets are widely used but can achieve release for only a limited amount of time before they pass through the digestive system.
Additionally, the stimuli source may be large, expensive, or too complex for frequent use.
Moreover, fabrication procedures for implants such as microspheres are usually complex, and the solvents or heat used during fabrication can adversely affect the stability of the drugs contained in the microspheres.
The device can contain hundreds of wells and be used as a microtitre plate array, holding reagents of interest, but it is not designed to provide any sort of controlled release or delivery function.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Multi-reservoir device for controlled drug delivery
  • Multi-reservoir device for controlled drug delivery
  • Multi-reservoir device for controlled drug delivery

Examples

Experimental program
Comparison scheme
Effect test

example 1

Fabrication of Polymeric Microchip Device Having Cholesterol Reservoir Caps

[0086] The following procedure was used to produce a polymeric microchip device having cholesterol reservoir caps for passive release.

(1) Weighed 0.4 g of poly(lactic-co-glycolic acid) powder, molecular weight ˜25,000 powder (see FIG. 4a).

(2) Inserted bottom piston into conical steel die. 1.27 cm (½″) in diameter, filled with polymer powder from step (1), and inserted top piston into die (see FIG. 4b).

(3) Put the die with powder into Carver Laboratory Press, model C. Pressed at room temperature for one minute and thirty seconds at approximately 69×106 Pa (10,000 psi), yielding a cylindrical polymer preform (see FIG. 4c).

(4) Removed cylindrical polymer preform from the die (see FIG. 4d).

[0087] (5) Placed cylindrical polymer preform into aluminum die plate (aluminum sheet, approximately 3 mm (or ⅛″) thick, with a hole of approximately the same diameter as the polymer preform). Allowed die plate to res...

example 2

Fabrication of Polymeric Microchip Device Having Cholesterol / Lecithin Reservoir Caps

[0093] The following alternative procedure was used to produce a polymeric microchip device having cholesterol / lecithin reservoir caps for passive release.

(1)-(4) Followed steps (1) through (4) described in Example 1 to form a polymer preform.

[0094] (5) Placed cylindrical polymer preform into aluminum die plate (aluminum sheet, approximately 3 mm (or ⅛″) thick, with a hole of approximately the same diameter as the polymer preform). Allowed die plate to rest on aluminum plate having conical indenters, and covered top with another aluminum plate, 3 mm (or ⅛″) thick.

[0095] (6) Placed the assembly from (5) into Carver Laboratory Press, model C, at 54° C. (130° F.). Set temperature of heated platens to 54° C. (130° F.). The load pressure remained at approximately 8896 N (2000 pounds-force). The assembly was left in the lab press for approximately ten minutes. A hole machined in the side of the indent...

example 3

Fabrication of Polymeric Microchip Device Having Polymeric Reservoir Caps

[0098] The following procedure was used to produce a polymeric microchip device having polyester reservoir caps for passive release.

(1) Weighed desired amount of a polymer powder (see FIG. 4a). Here, 0.4 g of poly(lactic acid) (MW approximately 100,000) was used.

(2) Inserted bottom piston into conical steel die , 1.27 cm (½ inch) in diameter, filled die with polymer powder from step (1), and inserted top piston into die (see FIG. 4b).

(3) Placed the die with powder into Carver Laboratory Press, model C. Pressed at room temperature for one minute and thirty seconds at approximately 69×106 Pa (10,000 psi), yielding a cylindrical polymer preform (see FIG 4c).

(4) Removed cylindrical polymer preform from the die (see FIG. 4d).

[0099] (5) Placed polymer preform on aluminum die plate containing an array of indenters for forming the reservoirs in the polymeric substrate. An aluminum plate 3 mm thick, with a 1.2...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

An implantable device for the controlled release of drug or diagnostic molecules in vivo which includes a substrate formed of a metal or a polyethylene, a plurality of discrete reservoirs provided in spaced positions in the substrate, and a release system disposed in the at least two reservoirs, wherein the release system comprises drug or diagnostic molecules combined with a release-controlling polymer matrix, wherein the kinetics of release of the drug or diagnostic molecules is controlled by disintegration of the polymeric matrix. The substrate and reservoirs therein may be made by a manufacturing technique which comprises compression molding, thermoforming, casting, laser cutting, etching, or a combination thereof.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This is a continuation of U.S. application Ser. No. 10 / 886,405, filed Jul. 7, 2004, which is a divisional of U.S. application Ser. No. 09 / 727,858, filed Dec. 1, 2000, now U.S. Pat. No. 6,808,522. application Ser. No. 09 / 727,858 claims benefit of U.S. Provisional application Ser. No. 60 / 170,218, filed Dec. 10, 1999. The disclosure of U.S. application Ser. No. 10 / 886,405 is incorporated herein by reference in its entirety.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0002] This invention was made with government support under NIH-R24-AI47739 awarded by the National Institutes of Health. The government has certain rights in the invention.BACKGROUND OF THE INVENTION [0003] This invention relates to miniaturized drug delivery devices and more particularly, to controlled time and rate release multi-welled drug delivery devices. [0004] The efficacy of many drugs is directly related to the way in which they are administered. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/22A61K9/00A61N1/30A61K9/20A61K47/02A61K47/30A61M37/00
CPCA61K9/0009Y10T436/25A61K9/0097A61K9/0024
Inventor RICHARDS, AMY C.SANTINI, JOHN T. JR.CIMA, MICHAEL J.LANGER, ROBERT S.
Owner MASSACHUSETTS INST OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap