Determination of AM-binding proteins and the association of adrenomedullin (AM) therewith

a technology of adrenomedullin and am, which is applied in the field of detection of adrenomedullin (am)binding proteins, can solve the problems of reducing the levels of insulin in the bloodstream, and achieve the effects of inhibiting am/fh activity, affecting am/fh activity, and affecting am/fh activity
US20070025915A1Inactive Publication Date: 2007-02-01UNITED STATES OF AMERICA
3 Cites 11 Cited by

Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
UNITED STATES OF AMERICA
Publication Date
2007-02-01
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The present invention provides methods for the isolation, identification, and purification of adrenomedullin (AM)-binding proteins. Also, provided are methods for utilizing the purified AM-binding proteins, or functional portions thereof, to diagnose, treat, and monitor AM-related diseases, for example, diseases or disorders associated with abnormally elevated AM levels. In addition, the present invention provides a newly identified complex between AM and a specific AM-binding protein 1 (AMBP-1); which has been isolated and identified herein as factor H (fH). The invention also provides AM / AMBP complexes, particularly AM / FH complexes, and antibodies specifically reactive with this complexes. Further provided are methods for identifying and purifying complexes of AM and an AM binding protein using anti-AM / fH antibodies, and methods for treating conditions such as cancer or diabetes utilizing compositions comprising these antibodies. The present invention additionally provides methods for identifying antagonists agents that inhibit the function of AM, factor H, or the AM / factor H complex. The invention also provides methods for treating conditions such as cancer or diabetes using these antagonist agents.
Need to check novelty before this filing date? Find Prior Art

Description

RELATED APPLICATION

[0001] This application is related to U.S. Provisional Application Ser. No. 60 / 153,397 filed Sep. 10, 1999, the contents of which are herein incorporated by reference.FIELD OF THE INVENTION

[0002] The present invention relates to newly developed methods for the detection of adrenomedullin (AM)-binding proteins. The invention further relates to the isolation, identification, and use of such AM-binding proteins, and to compositions and methods including these proteins. The AM-binding proteins can be employed in the diagnosis, treatment and monitoring of AM-related diseases. The present invention also relates to the isolation of AM / AM-binding protein complexes, the generation of antibodies to these complexes, and the use of these antibodies to detect AM / AM-binding protein complexes and treat AM-related diseases. The invention further relates to a newly discovered complex comprising AM and a newly identified AM binding protein, human complement factor H (fH; factor H...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More