Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue

a non-excitatory electrical signal and calcium concentration technology, applied in electrotherapy, heart stimulators, therapy, etc., can solve the problems of cardiac output reduction, cardiac output reduction, normal regulatory mechanisms may be damaged, etc., and achieve the effect of increasing the contractility of the heart and increasing the systolic pressure generated by the hear
US20070239216A9Inactive Publication Date: 2007-10-11IMPULSE DYNAMICS NV
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
IMPULSE DYNAMICS NV
Publication Date
2007-10-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

According to a method and device for modulating intracellular calcium concentration in biological tissue, a stimulation probe is applied to the tissue, a non-excitatory stimulation pulse is generated, and the pulse is conveyed to the stimulation probe. In one embodiment concerning cardiac tissue, a stimulation probe is applied to a patient's heart, a signal is received from at least one sensor responsive to the patient's cardiac muscle activity, a non-excitatory stimulation pulse responsive to the signal is generated, and the pulse is conveyed to the stimulation probe.
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Description

CROSS-REFERENCE TO RELATED APPLICATION

[0001] This application claims the benefit of U.S. Provisional Patent Application Serial No. 60 / 157,511, filed Oct. 4, 1999, which is assigned to the assignee of the present patent application and is incorporated herein by reference.FIELD OF THE INVENTION

[0002] This invention relates generally to invasive devices and methods for treatment of the heart, including devices and methods for stimulation of the heart muscle. More particularly, this invention relates to control of cellular tissue, specifically the modulation of intracellular calcium concentration in cardiac muscle cells. BACKGROUND OF THE INVENTION

[0003] Cardiac insufficiency, characterized inter alia by a reduction in cardiac output, is a common, well-known and well-documented heart malfunction. It develops as a result of congenital defects or as an end-effect of many diseases. Cardiac output, i.e., the output of the heart per unit time, is the product of stroke volume and heart rat...

Claims

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