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Coated material and process for producing the coated material

a coating agent and coating technology, applied in the field of coating agents, can solve the problems of poor handling, high cost, and poor environmental effects of most conventionally known coating agents

Inactive Publication Date: 2008-02-21
KIRIN BREWERY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The solution provides a non-sticky coating with controlled dissolution, low oxygen permeability, and improved safety, suitable for various applications including food and pharmaceutical products, without the drawbacks of conventional agents, such as gum arabic or shellac.

Problems solved by technology

Most of such conventionally known coating agents, however, suffer from the drawback of poor handling; as a result of stickiness or poor dispersion during the preparation of the coating liquid.
Additional problems with most medicinal additives such as shellac, zein (corn protein), and ethylcellulose, are their bad effects on the environment and their high cost because of the use of solvents such as ethanol have been indicated.
Although water dispersion types of ethylcellulose-based coating agents have become commercially available recently, these also suffer from problems in terms of handling, such as the changes in solution properties depending on temperature conditions during storage, and the inability to release them in wastewater into rivers because they contain various solvents.
Still another problem is the poor intestinal dissolution and the extremely slow dissolution speed of the aforementioned zein which can be used in the field of food products.
However, it has not been known that excellent use as a coating agent can be made, without additional chemical treatment, of yeast cell wall fractions consisting of yeast extract residue, for example, such as extract residue obtained after the components in soluble cells have been removed following the autolysis of live yeast cream at 40 to 50° C., or that further treatment of such yeast cell wall fractions with acidic aqueous solution affords a coating agent with better enteric properties allowing the time at which dissolution begins to be controlled.

Method used

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  • Coated material and process for producing the coated material
  • Coated material and process for producing the coated material
  • Coated material and process for producing the coated material

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0041] Brewer's yeast-slurry by-product was procured from a beer plant and was centrifuged for 10 minutes at 4500 rpm, and the resulting slushy live yeast was suspended in water to a solids concentration of 5 wt %. The suspension was allowed to undergo autolysis for 17 hours at 50° C., the product was centrifuged again to remove the soluble internal cell components, and the resulting autolysis residue was used as the yeast cell wall fraction. Then the yeast cell wall fraction was dispersed in water to a solids concentration of 10 wt %, and glycerin was dispersed as a plasticizer to 15 wt % of the yeast cell wall fraction solids, so as to prepare a coating liquid.

[0042] As the encapsulated substance, tablets consisting of 3.6 mg acetaminophen, 112.8 mg lactose, 3.0 mg HPC-L, and 0.6 mg magnesium stearate (total of 120 mg / tablet) were formed in advance, and these tablets were spray coated with the coating liquid using a Doria Coater (Powrex Co., Ltd) to a tablet:coating agent ratio o...

example 2

[0044] Samples were prepared in the same manner as in Example 1 except that torula yeast was used instead of the brewer's yeast used in Example 1. The same dissolution test (paddle method) based on the Japan Pharmacopoeia revealed results similar to those for Sample 1 in Example 1.

example 3

[0045] Brewer's yeast slurry by-product was procured from a beer plant and was centrifuged for 10 minutes at 4500 rpm, and the resulting slushy live yeast was suspended in water to a solids concentration of 5 wt %. 10,000 U of a Zymoliase 20T (Seikagaku Kogyo) was added to 500 g of the suspension and allowed to act thereon for 8 hours at 37° C., the mixture was centrifuged again to remove the soluble internal cell components, and the resulting autolysis residue was used as the yeast cell wall fraction. The yeast cell wall fraction was then treated in the same manner as in Example 1 to prepare samples. The same dissolution test (paddle method) based on the Japan Pharmacopoeia revealed results similar to those for Sample 1 in Example 1.

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Abstract

A coated material and a process for producing the coated material which includes providing a coating agent comprising yeast cell wall fractions, as a primary constituent, consisting of cell residue of yeast which has been treated with enzymes, optionally subsequently with acidic solution, and water to remove internal soluble cell constituents; and coating a solid material with the coating agent to provide a coating thereon.

Description

CROSS REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation of application Ser. No. 09 / 514,312, filed Feb. 28, 2000, and claims priority to Japanese Patent Application No. 11-50291, filed Feb. 26, 1999, the entire contents of each of which are incorporated herein by reference.BACKGROUND OF THE INVENTION [0002] 1. Field of the Invention [0003] The present invention relates to a coating agent which is safe to use, which can be coated even in 100% water, which affords a finish that is not sticky despite its viscosity, thus resulting in coated particles that do not stick to each other, and which has an extremely low oxygen permeation coefficient, as well as to a novel, edible coating agent consisting of yeast cell wall fractions with the function of controlling dissolution time, coated materials comprising the use of such coating agents, and a coating film formed from such a coating agent. [0004] 2. Description of the Related Art [0005] Fine particles, microcapsule...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A01N63/04
CPCA61K9/5063
Inventor KASAI, TAKAHIDEEGUCHI, TAKAHIROTAKAI, KIMIKO
Owner KIRIN BREWERY CO LTD