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Thiazolidinedione analogues

a technology of thiazolidinedione and analogues, applied in the field of pharmaceutical compositions, can solve the problems of sodium reabsorption and other unpleasant side effects, and achieve the effects of stimulating transcription, and reducing binding and activation of the nuclear transcription factor ppar

Inactive Publication Date: 2009-06-04
METABOLIC SOLUTIONS DEVMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007]In general, the invention relates to insulin sensitizers that have reduced binding and activation of the nuclear transcription factor PPARγ. Traditional insulin sensitizers activate PPARγ and stimulate the transcription of genes that favor sodium re-absorption. The insulin sensitizers of this invention have reduced binding and activation of the nuclear transcription factor PPARγ and therefore produce reduced sodium re-absorption and fewer dose-limiting side effects. Thus, these compounds are substantially more effective to treat and prevent diabetes and other metabolic inflammation mediated diseases including all aspects of insulin resistance associated with metabolic syndrome including dyslipidemia, and central obesity. These compounds are also useful for treating other inflammatory diseases such as rheumatoid arthritis, lupus, myasthenia gravis, vasculitis, Chronic Obstructive Pulmonary Disease (COPD), nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and inflammatory bowel disease as well as neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple schlerosis.

Problems solved by technology

However, compounds that involve the activation of PPARγ also trigger sodium reabsorption and other unpleasant side effects.

Method used

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Examples

Experimental program
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example 1

Formulation of Pharmaceutical Compositions

[0149]A pharmaceutical composition including a compound of formulae I, Ia, II, III, IV, V, or VI can be produced, for example, by tableting[0150]a. between about 1 mg to about 200 mg of a compound of formulae I, Ia, II, III, IV, V, or VI, e.g., between about 10 mg to about 100 mg, or between about 15 mg to about 60 mg;[0151]b. carboxymethylcellulose or carmellose;[0152]c. magnesium sterate,[0153]d. hydroxypropyl cellulose; and[0154]e. lactose monohydrate.

example 2a

Assays for Measuring Reduced PPARγ Receptor Activation

[0155]Whereas activation of the PPARγ receptor is generally believed to be a selection criteria to select for molecules that may have anti-diabetic and insulin sensitizing pharmacology, this invention finds that activation of this receptor should be a negative selection criterion. Molecules will be chosen from this chemical space because they have reduced, not just selective, activation of PPARγ. The optimal compounds will have at least a 10-fold reduced potency as compared to pioglitazone and less than 50% of the full activation produced by rosiglitazone in assays conducted in vitro for transactivation of the PPARγ receptor. These assays will be conducted by first evaluation of the direct interactions of the molecules with the ligand binding domain of PPARγ. This will be performed with a commercial interaction kit that measures the direct interaction by florescence using rosiglitazone as a positive control. Further assays will b...

example 2b

Measuring PPARγ Receptor Activation

[0158]The ability of several exemplary compounds of the present invention, shown in Table A, to bind to PPARγ was measured using a commercial binding assay (Invitrogen Corporation, Carlsbad, Calif.) that measures the test compounds ability to bind with PPAR-LBD / Fluormone PPAR Green complex. These assays were performed on three occasions with each assay using four separate wells (quadruplicate) at each concentration of tested compound. The data are mean and SEM of the values obtained from the three experiments. Rosiglitazone was used as the positive control in each experiment. Compounds were added at the concentrations shown, which range from 0.1-100 micromolar. In Table B, “—” indicates that no data is available.

TABLE BActivation of PPARγ.Compound(μM).01 μM.03 μM.1 μM.3 μM1 μM3 μM10 μM50 μM100 μMRosiglitazone230208169138— 93 83 76 74 (13) (15) (15) (5) (2) (2) (4) (5)Compound 1——227232223228207174170 (1) (8) (12) (6) (13) (28) (35)Compound 2——23123...

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Abstract

The present invention relates to thiazolidinedione analogues that are useful for treating metabolic inflammation mediated diseases such as diabetes.

Description

CLAIM OF PRIORITY[0001]This application is a continuation-in-part of PCT application No. PCT / US2007 / 006321, filed Mar. 14, 2007, which claims the benefit of U.S. Provisional application No. 60 / 782,894, filed on Mar. 16, 2006, each of which is hereby incorporated by reference in its entirety.TECHNICAL FIELD OF THE INVENTION[0002]The present invention provides a pharmaceutical composition that includes selective thiazolidinedione analogs for use in treating metabolic inflammation mediated diseases.BACKGROUND OF THE INVENTION[0003]Over the past several decades, scientists have postulated that PPARγ is the generally accepted site of action for insulin sensitizing thiazolidinedione compounds.[0004]Peroxisomes Proliferator Activated Receptors (PPARs) are members of the nuclear hormone receptor super family, which are ligand-activated transcription factors regulating gene expression. PPARs have been implicated in autoimmune diseases and other diseases, i.e diabetes mellitus, cardiovascular...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/4439A61P29/00
CPCA61K31/4439A61P1/00A61P1/04A61P3/04A61P3/06A61P3/10A61P9/00A61P11/00A61P19/02A61P21/04A61P25/00A61P25/16A61P25/28A61P29/00A61P37/00A61P37/06A61P37/08A61P43/00A61K31/4427A61K31/4436
Inventor COLCA, GERARD R.KLETZIEN, ROLF F.
Owner METABOLIC SOLUTIONS DEVMENT
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