Use of nutritional compositions with phospholipid, sphingolipid and cholesterol.

a nutritional composition and phospholipid technology, applied in the field of preventing obesity, can solve the problems of increased risk of developing obesity later in life, high blood insulin levels, and inability to prevent obesity, and achieve the effects of stimulating the formation of excess visceral fat, increasing adipose tissue mass, and high blood insulin

Inactive Publication Date: 2009-07-23
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006]In infants high blood insulin levels stimulate glucose uptake in adipose tissue, resulting in an increased adipose tissue mass. Furthermore, high blood insulin levels stimulate the formation of excess visceral fat. Excess visceral fat results in an increased chance to develop obesity later in life.
[0007]The present invention can therefore advantageously be used to prevent obesity later-in-life, but also to prevent the development of diabetes later in life. Inclusion of the present combination in infant nutrition reduces blood insulin levels and thereby the prevents the development of obesity and / or diabetes later in life. Since in infants high blood insulin levels particularly stimulate visceral adipocyte proliferation, the composition is particularly suitable to prevent visceral obesity.

Problems solved by technology

Furthermore, high blood insulin levels stimulate the formation of excess visceral fat.
Excess visceral fat results in an increased chance to develop obesity later in life.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

pids Beneficially Affect Insulin Sensitivity

[0049]Nutritional compositions: A complete infant formula comprising lactose, galacto-oligosacharides with a DP 2-6 and fructo-oligosaccharides with DP 7-60 with extra added phospholipids (0.2 g / 100 ml) was manufactured using a commercially available buttermilk / butter serum concentrate of Lactalis as source. An infant formula with a comparable composition, but without added phospholipids was used as control. The concentration of phospholipids was about 6.3 wt. % based on total lipid in the experimental formula and about 0.75 wt. % based on total lipid in the control formula. The experimental composition comprised about 1.4 wt. % sphingomyelin based on total lipid and about 4 wt. % cholesterol based on total lipid. The amount of sphingomyelin and cholesterol was negligible in the control formula.

[0050]Methods: 20 adult male Wistar rats (aged 10 weeks at the start of the experiment) were housed individually. After a 4 h fasting period, 10 an...

example 2

cose / Insulin and Non-digestible Oligosaccharides

[0052]Animals and treatment: Adult male Wistar rats (n=7) were given a GOS fiber load, cellulose load or water via a gastric canula on day 1. A 6 ml bolus load was administered equal to 50% of their daily fiber intake; GOS fiber used was transgalacto-oligosaccharides obtained from Elix'or (Borculo Domo). Fiber was dissolved in water. About 24 h later (on day 2) an oral glucose tolerance test was carried out and the postprandial glucose and insulin course was monitored for 120 min upon the intragastric injection of a carbohydrate load (2 g / kg body weight). To this end blood samples were drawn repeatedly via a jugular vein canula. Intragastric injection of water or a cellulose solution in water on day 1 served as control. As the GOS fiber preparation consisted of 50% of digestible carbohydrates (mainly lactose), the two control injections were co-administered with carbohydrates to correct for this.

[0053]Results: pre-treatment with GOS fi...

example 3

trition

[0054]Infant nutrition comprising a lipid component providing 48% of the total calories, a protein component providing 8% of the total calories and a digestible carbohydrate component providing 44% of the total calories;[0055](i) the lipid component comprising based on total fatty acids: 14 wt. % LA; 2.6 wt. % ALA, 3.7 wt. % MCFA; 0.2 wt. % DHA, 0.05 wt. % EPA; 0.02 wt. % DPA, 0.35 wt. % AA, 0.03 wt. % DHGLA. The composition comprises about 5.6 wt. % phospholipids, 1.4 wt. % sphingomyelin and about 4 wt. % cholesterol based on total lipid.[0056](ii) the carbohydrate component comprising 50.9 gram lactose / 100 gram powder, 5.22 g galacto-oligosaccharides with DP 2-6 and 0.58 g fructo-oligosaccharides with DP 7-60 per 100 g powder; (ii) the protein component comprising cow milk protein, including casein. Furthermore the composition comprises 73 mg choline and 5.6 mg UMP per 100 g powder. The composition comprises vitamins and minerals according to EU guidelines. The label of the...

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Abstract

A nutritional composition comprising phospholipids, sphingolipids and cholesterol for the prevention of obesity and/or diabetes is provided.

Description

FIELD OF THE INVENTION[0001]The present invention relates to preventing obesity by administering a nutritional composition to non-obese infants with the age below 3 years. In a further embodiment the present invention relates to the treatment and / or prevention of type 2 diabetes.BACKGROUND OF THE INVENTION[0002]Breast-feeding is the preferred method of feeding infants. However, there are circumstances that make breast-feeding impossible or less desirable. In those cases infant formulae are a good alternative. The composition of modem infant formulae is adapted in such a way that it meets many of the special nutritional requirements of the fast growing and developing infant.[0003]Still it seems that improvements can be made towards the constitution of infant milk formulae. For example little is known about the effects of ingredients in the infant formulae on obesity later in life. The present invention relates to such future health.[0004]EP 1566439 pertains to a method for preventing...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/00A23L33/00
CPCA23L1/296A23L1/3008A23V2002/00A61K31/185A61K31/198A61K31/20A61K35/20A23V2250/1882A23V2250/1878A23V2250/54246A23V2250/612A23V2250/28A23V2250/1846A23L33/40A23L33/12A23L33/125A61K31/14A61K31/201A61K31/202A61K31/575A61K31/688A61K31/7016A61K31/702A61K38/1709A61P25/00A61P3/02A61P3/04A61P3/06A61P9/00A61P9/10A61P3/10
Inventor ZWIJSEN, RENATE MARIA LOUISEBOEHM, GUNTHER
Owner NV NUTRICIA
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