Use of nutritional compositions with phospholipid, sphingolipid and cholesterol.

Abstract

A nutritional composition comprising phospholipids, sphingolipids and cholesterol for the prevention of obesity and / or diabetes is provided.

Description

FIELD OF THE INVENTION

[0001] The present invention relates to preventing obesity by administering a nutritional composition to non-obese infants with the age below 3 years. In a further embodiment the present invention relates to the treatment and / or prevention of type 2 diabetes.BACKGROUND OF THE INVENTION

[0002] Breast-feeding is the preferred method of feeding infants. However, there are circumstances that make breast-feeding impossible or less desirable. In those cases infant formulae are a good alternative. The composition of modem infant formulae is adapted in such a way that it meets many of the special nutritional requirements of the fast growing and developing infant.

[0003] Still it seems that improvements can be made towards the constitution of infant milk formulae. For example little is known about the effects of ingredients in the infant formulae on obesity later in life. The present invention relates to such future health.

[0004] EP 1566439 pertains to a method for preventing...

Examples

example 1

pids Beneficially Affect Insulin Sensitivity

[0049]Nutritional compositions: A complete infant formula comprising lactose, galacto-oligosacharides with a DP 2-6 and fructo-oligosaccharides with DP 7-60 with extra added phospholipids (0.2 g / 100 ml) was manufactured using a commercially available buttermilk / butter serum concentrate of Lactalis as source. An infant formula with a comparable composition, but without added phospholipids was used as control. The concentration of phospholipids was about 6.3 wt. % based on total lipid in the experimental formula and about 0.75 wt. % based on total lipid in the control formula. The experimental composition comprised about 1.4 wt. % sphingomyelin based on total lipid and about 4 wt. % cholesterol based on total lipid. The amount of sphingomyelin and cholesterol was negligible in the control formula.

[0050]Methods: 20 adult male Wistar rats (aged 10 weeks at the start of the experiment) were housed individually. After a 4 h fasting period, 10 an...

example 2

cose / Insulin and Non-digestible Oligosaccharides

[0052]Animals and treatment: Adult male Wistar rats (n=7) were given a GOS fiber load, cellulose load or water via a gastric canula on day 1. A 6 ml bolus load was administered equal to 50% of their daily fiber intake; GOS fiber used was transgalacto-oligosaccharides obtained from Elix'or (Borculo Domo). Fiber was dissolved in water. About 24 h later (on day 2) an oral glucose tolerance test was carried out and the postprandial glucose and insulin course was monitored for 120 min upon the intragastric injection of a carbohydrate load (2 g / kg body weight). To this end blood samples were drawn repeatedly via a jugular vein canula. Intragastric injection of water or a cellulose solution in water on day 1 served as control. As the GOS fiber preparation consisted of 50% of digestible carbohydrates (mainly lactose), the two control injections were co-administered with carbohydrates to correct for this.

[0053]Results: pre-treatment with GOS fi...

example 3

trition

[0054]Infant nutrition comprising a lipid component providing 48% of the total calories, a protein component providing 8% of the total calories and a digestible carbohydrate component providing 44% of the total calories;[0055](i) the lipid component comprising based on total fatty acids: 14 wt. % LA; 2.6 wt. % ALA, 3.7 wt. % MCFA; 0.2 wt. % DHA, 0.05 wt. % EPA; 0.02 wt. % DPA, 0.35 wt. % AA, 0.03 wt. % DHGLA. The composition comprises about 5.6 wt. % phospholipids, 1.4 wt. % sphingomyelin and about 4 wt. % cholesterol based on total lipid.[0056](ii) the carbohydrate component comprising 50.9 gram lactose / 100 gram powder, 5.22 g galacto-oligosaccharides with DP 2-6 and 0.58 g fructo-oligosaccharides with DP 7-60 per 100 g powder; (ii) the protein component comprising cow milk protein, including casein. Furthermore the composition comprises 73 mg choline and 5.6 mg UMP per 100 g powder. The composition comprises vitamins and minerals according to EU guidelines. The label of the...

FIELD OF THE INVENTION

[0001] The present invention relates to preventing obesity by administering a nutritional composition to non-obese infants with the age below 3 years. In a further embodiment the present invention relates to the treatment and / or prevention of type 2 diabetes.BACKGROUND OF THE INVENTION

[0002] Breast-feeding is the preferred method of feeding infants. However, there are circumstances that make breast-feeding impossible or less desirable. In those cases infant formulae are a good alternative. The composition of modem infant formulae is adapted in such a way that it meets many of the special nutritional requirements of the fast growing and developing infant.

[0003] Still it seems that improvements can be made towards the constitution of infant milk formulae. For example little is known about the effects of ingredients in the infant formulae on obesity later in life. The present invention relates to such future health.

[0004] EP 1566439 pertains to a method for preventing...

Examples

example 1

pids Beneficially Affect Insulin Sensitivity

[0049]Nutritional compositions: A complete infant formula comprising lactose, galacto-oligosacharides with a DP 2-6 and fructo-oligosaccharides with DP 7-60 with extra added phospholipids (0.2 g / 100 ml) was manufactured using a commercially available buttermilk / butter serum concentrate of Lactalis as source. An infant formula with a comparable composition, but without added phospholipids was used as control. The concentration of phospholipids was about 6.3 wt. % based on total lipid in the experimental formula and about 0.75 wt. % based on total lipid in the control formula. The experimental composition comprised about 1.4 wt. % sphingomyelin based on total lipid and about 4 wt. % cholesterol based on total lipid. The amount of sphingomyelin and cholesterol was negligible in the control formula.

[0050]Methods: 20 adult male Wistar rats (aged 10 weeks at the start of the experiment) were housed individually. After a 4 h fasting period, 10 an...

example 2

cose / Insulin and Non-digestible Oligosaccharides

[0052]Animals and treatment: Adult male Wistar rats (n=7) were given a GOS fiber load, cellulose load or water via a gastric canula on day 1. A 6 ml bolus load was administered equal to 50% of their daily fiber intake; GOS fiber used was transgalacto-oligosaccharides obtained from Elix'or (Borculo Domo). Fiber was dissolved in water. About 24 h later (on day 2) an oral glucose tolerance test was carried out and the postprandial glucose and insulin course was monitored for 120 min upon the intragastric injection of a carbohydrate load (2 g / kg body weight). To this end blood samples were drawn repeatedly via a jugular vein canula. Intragastric injection of water or a cellulose solution in water on day 1 served as control. As the GOS fiber preparation consisted of 50% of digestible carbohydrates (mainly lactose), the two control injections were co-administered with carbohydrates to correct for this.

[0053]Results: pre-treatment with GOS fi...

example 3

trition

[0054]Infant nutrition comprising a lipid component providing 48% of the total calories, a protein component providing 8% of the total calories and a digestible carbohydrate component providing 44% of the total calories;[0055](i) the lipid component comprising based on total fatty acids: 14 wt. % LA; 2.6 wt. % ALA, 3.7 wt. % MCFA; 0.2 wt. % DHA, 0.05 wt. % EPA; 0.02 wt. % DPA, 0.35 wt. % AA, 0.03 wt. % DHGLA. The composition comprises about 5.6 wt. % phospholipids, 1.4 wt. % sphingomyelin and about 4 wt. % cholesterol based on total lipid.[0056](ii) the carbohydrate component comprising 50.9 gram lactose / 100 gram powder, 5.22 g galacto-oligosaccharides with DP 2-6 and 0.58 g fructo-oligosaccharides with DP 7-60 per 100 g powder; (ii) the protein component comprising cow milk protein, including casein. Furthermore the composition comprises 73 mg choline and 5.6 mg UMP per 100 g powder. The composition comprises vitamins and minerals according to EU guidelines. The label of the...