Novel Compounds for Treatment of Cancer and Disorders Associated with Angiogenesis Function

a technology of angiogenesis and therapeutic compounds, which is applied in the direction of heterocyclic compound active ingredients, biocide, drug compositions, etc., can solve the problems of inability to achieve easy and straightforward ways with current technologies, and inability to achieve oral anticancer drugs. , to achieve the effect of modulating (increasing or decreasing) expression and low density lipoprotein
US20100120781A1Inactive Publication Date: 2010-05-13UNIV OF SOUTHERN CALIFORNIA
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
UNIV OF SOUTHERN CALIFORNIA
Publication Date
2010-05-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating cell growth, cell cycle, apoptosis, or gene expression.
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Description

RELATED APPLICATIONS

[0001] The present application is a continuation-in-part of pending prior U.S. patent application Ser. No. 11 / 027,465 filed on Dec. 29, 2004. The present application also claims priority to U.S. Provisional Application Ser. No. 60 / 624,253 filed on Nov. 1, 2004. The contents of U.S. patent application Ser. No. 11 / 027,465 and U.S. Provisional Application Ser. No. 60 / 624,253 are incorporated herein by reference.FIELD OF THE INVENTION

[0002] The present invention relates to therapeutic compounds for treatment of cancer and disorders associated with angiogenesis function. More specifically, the invention relates to novel compounds and their uses in treating cancer such as leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer, as well as disorders associated with angiogenesis function such as age-related macular degeneration, macular dystrophy, and diabetes.BACKGROUND OF THE INVENTION[000...

Claims

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