Biologically active proteins having increased In Vivo and/or In Vitro stability

a technology of biological active proteins and stability, which is applied in the direction of peptide/protein ingredients, depsipeptides, dna preparations, etc., can solve the problems of reduced or no therapeutic activity, significant product loss, and difficult manufacturing and characterization of mixtures
US20100189682A1Inactive Publication Date: 2010-07-29AMUNIX OPERATING INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
AMUNIX OPERATING INC
Publication Date
2010-07-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
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Description

CROSS-REFERENCE

[0001] This application claims the benefit of U.S. Provisional Application No. 60 / 743,410 filed Mar. 6, 2006, which application is incorporated herein by reference. This application is a continuation-in-part application of Ser. Nos. 11 / 528,927 and 11 / 528,950, filed on Sep. 27, 2006, which in turn claim priority to provisional applications Ser. Nos. 60 / 721,270, 60 / 721,188, filed on Sep. 27, 2005 and 60 / 743,622 filed on Mar. 21, 2006, all of which are herein incorporated by reference in their entirety.BACKGROUND OF THE INVENTION

[0002] It has been well documented that properties of proteins, in particular plasma clearance and immunogenicity, can be improved by attaching hydrophilic polymers to these proteins (Kochendoerfer, G. (2003) Expert Opin Biol Ther, 3: 1253-61), (Greenwald, R. B., et al. (2003) Adv Drug Deliv Rev, 55: 217-50), (Harris, J. M., et al. (2003) Nat Rev Drug Discov, 2: 214-21). Examples of polymer-modified proteins that have been approved by the FDA for t...

Claims

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