Macrocyclic compounds and their use as kinase inhibitors

a technology of macrocyclic compounds and kinase inhibitors, applied in the field of macrocyclic compounds, can solve the problems of adversely affecting patient health, poor prognosis, and elevated levels of circulating cytokines, and achieve the effect of efficient treatment and few associated clinical side effects
US20100190804A1Active Publication Date: 2010-07-29INCYTE CORP
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
INCYTE CORP
Publication Date
2010-07-29

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Abstract

The present invention relates to macrocyclic compounds of Formula I:or pharmaceutically acceptable salts thereof or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are JAK / ALK inhibitors useful in the treatment of JAK / ALK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
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Description

[0001] This application claims benefit of priority to U.S. provisional patent application Ser. No. 61 / 146, 824 filed Jan. 23, 2009, which is hereby incorporated by reference in its entirety.FIELD OF THE INVENTION

[0002] The present invention relates to macrocyclic compounds, and compositions thereof as well as methods of use the same for treatment of Janus Kinase and / or Anaplastic Lymphoma Kinase (JAK / ALK)-associated diseases including, for example, inflammatory disorders, autoimmune disorders, skin disorders, myeloid proliferative disorders, as well as cancer.BACKGROUND OF THE INVENTION

[0003] Protein kinases (PKs) are a group of enzymes that regulate diverse, important biological processes including cell growth, survival and differentiation, organ formation and morphogenesis, neovascularization, tissue repair and regeneration, among others. Protein kinases exert their physiological functions through catalyzing the phosphorylation of proteins (or other substrates such as lipids) and the...

Claims

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