Particles containing an opioid receptor antagonist and methods of use

a technology of opioid receptor and opioid receptor, applied in the field of opioid receptor antagonists and drug delivery, can solve the problems of limited efficacy of common treatments of bulking agents and laxatives, affecting so as to improve the absorption of opioid receptor antagonists. , the effect of reducing the dose required
US20110250278A1Inactive Publication Date: 2011-10-13UNIVERSITY OF CHICAGO
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
UNIVERSITY OF CHICAGO
Publication Date
2011-10-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

Particles comprising an opioid receptor antagonist as well as methods of their use and methods of their preparation are provided herein. Such particles may be used for treating and preventing opioid-induced side effects in patients, and may be provided to chronic opioid users as well.
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Description

[0001] The present application claims the benefit of priority to U.S. Provisional Application No. 61 / 077,242, filed Jul. 1, 2008 the entire contents of this application being incorporated by reference.BACKGROUND OF THE INVENTION

[0002] 1. Field of the Invention

[0003] The present invention relates to the fields of opioid receptor antagonists and drug delivery. In general, particles comprising an opioid receptor antagonist are described along with methods of their use.

[0004] 2. Description of Related Art

[0005] Opioids are effective analgesics. However, their use is associated with a number of undesirable side effects. One such effect is constipation. Opioid-induced changes in gastrointestinal motility are almost universal when these drugs are used to treat pain, and at times may limit their use, leaving the patient in pain. Common treatments of bulking agents and laxatives have limited efficacy and may be associated with side effects such as electrolyte imbalances.

[0006] One treatment for op...

Claims

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