Ligand-directed covalent modification of protein

a covalent modification and protein technology, applied in the field of enzyme inhibitors, can solve the problems of protein target modification, other undesirable effects, and difficulty in developing reversible inhibitors that selectively inhibit one or more desired kinases, and achieve irreversible inhibition
US20110269244A1Inactive Publication Date: 2011-11-03CELGENE CAR LLC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
CELGENE CAR LLC
Publication Date
2011-11-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to enzyme inhibitors. More specifically, the present invention relates to ligand-directed covalent modification of proteins; method of designing same; pharmaceutical formulation of same; and method of use.
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Description

PRIORITY CLAIM

[0001] This application claims the benefit of U.S. provisional application 61 / 335,043, filed Dec. 30, 2009, the disclosure of which is relied on and incorporated by reference into the present application in its entirety. All patents, patent applications and referenced articles are hereby incorporated by reference into this application in their entireties.DESCRIPTION OF THE TEXT FILE SUBMITTED ELECTRONICALLY

[0002] The contents of the text file submitted electronically herewith are incorporated herein by reference in their entirety: A computer readable format copy of the Sequence Listing (filename: AVIL—001—01US_SeqList_ST25.txt, date recorded: Feb. 27, 2011, file size 26 kilobytes).FIELD OF THE INVENTION

[0003] The present invention relates to enzyme inhibitors. More specifically, the present invention relates to ligand-directed covalent modification of lysine-containing proteins.BACKGROUND OF THE INVENTION

[0004] Compounds that inhibit the activity of proteins, such as enzym...

Claims

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