Methods and pharmaceutical compositions for the treatment of respiratory tract infections

a technology of respiratory tract infections and pharmaceutical compositions, applied in the direction of antibacterial agents, aerosol delivery, peptide/protein ingredients, etc., can solve the problems of irritability, poor appetite, runny or stuffy nose,

Inactive Publication Date: 2013-06-13
INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM) +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Symptoms of upper respiratory tract infection include runny or stuffy nose, irritability, restlessness, poor appetite, decreased activity level, coughing, and fever.
Unfortunately, in regard to certain infections, there are no therapies available, infections have been proven to be refractory to therapies, or the occurrence of side effects outweighs the benefits of the administration of a therapy to a subject.
The use of anti-bacterial agents for treatment of bacterial respiratory tract infections may also produce side effects or result in

Method used

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  • Methods and pharmaceutical compositions for the treatment of respiratory tract infections
  • Methods and pharmaceutical compositions for the treatment of respiratory tract infections

Examples

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[0078]Material & Methods

[0079]Bacterial Preparation:

[0080]Streptococcus pneumoniae serotype 1 (clinical isolate E1586) was obtained from the National Reference Laboratory—Ministry of Health, Uruguay (39). Working stocks were prepared as follows. Todd Hewitt Yeast Broth (THYB) (Sigma-Aldrich, St. Louis—Mo., USA) was inoculated with fresh colonies of S. pneumoniae grown in blood-agar plates, and incubated at 37° C. until the culture reached OD600nm of 0.7-0.9 units. Cultures were stored at −80° C. in THYB+glycerol 12% (v / v) up to 3 months. For mouse infection, working stocks were thawed and washed with sterile physiological saline solution (saline) and diluted to the appropriate concentration. Number of bacteria in stocks was confirmed by plating serial dilutions onto blood agar plates.

[0081]Proteins:

[0082]Native flagellin (FliC) from Salmonella enterica Serovar Typhimurium SIN22, or recombinant flagellins (FliCΔ174-400 and FliCΔ174-400 / 89-96*) were prepared as previously described (2...

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Abstract

The present invention relates to methods and pharmaceutical compositions for the treatment of respiratory tract infections. More particularly, the present invention relates to a TLR5 agonist for use in a method for treating a respiratory tract infection.

Description

FIELD OF THE INVENTION[0001]The present invention relates to methods and pharmaceutical compositions for the treatment of respiratory tract infections. More particularly, the present invention relates to a TLR5 agonist for use in a method for treating a respiratory tract infection.BACKGROUND OF THE INVENTION[0002]Respiratory tract infections are common infections of the upper respiratory tract (e.g., nose, ears, sinuses, and throat) and lower respiratory tract (e.g., trachea, bronchial tubes, and lungs). Symptoms of upper respiratory tract infection include runny or stuffy nose, irritability, restlessness, poor appetite, decreased activity level, coughing, and fever.[0003]Viral respiratory tract infections cause and / or are associated with sore throats, colds, croup, and the flu. Examples of viruses that cause upper and lower respiratory tract infections include rhinoviruses and influenza viruses A and B.[0004]Common respiratory bacterial infections cause and / or associated with, for ...

Claims

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Application Information

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IPC IPC(8): A61K38/16
CPCC12Q1/18A61K38/164A61P11/00A61P31/04A61P31/10A61P31/12Y02A50/30A61K9/0043A61K9/007A61K9/08A61K9/12
Inventor SIRARD, JEAN-CLAUDECHABALGOITY, JOSE A.
Owner INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM)
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