Antiseptic, antiseborrheic, exfoliating composition for getting rid of or preventing acne

a technology of antibacterial, antiseborrheic and exfoliating composition, which is applied in the direction of antibacterial agents, drug compositions, antibacterial agents, etc., can solve the problems of ddo quickly losing its properties, dilating the follicular hole, and losing its properties

Inactive Publication Date: 2015-08-20
EXCALIBUR PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides pharmaceutical hydrosoluble compositions that have the ability to kill bacteria, remove skin flakes, and regulate sebum production to prevent or treat acne. These compositions contain a combination of diallyl disulphide modified oxide (DDMO) and alpha-hydroxyethanoic acid (glycolic acid).

Problems solved by technology

The resulting corneous material fall in the light of the follicle, which in addition to the fat excess forms wax substituting and easing the follicle walls, accordingly by not being able to excrete material, it inflames more, causing the first and most important acne elemental injury: the blackhead, causing dilation of the follicular hole due to the pressure the wax applies when trying to be expelled.
Since it is a not much stable compound, the DDO quickly loses its properties, on the other hand if garlic is heated over 60° C. it loses its properties.
It has a strong oxidative power that could cause harm to intestinal cells.
In 1944 Cavallito and his co-workers were able to isolate and identify the active compound from the extracts of Allium sativum which they called allicin and in 1947 they were able to synthesize the diallyl disulphide oxide (allicin), but unfortunately they were not able to make the molecule thereof stable, since it kept losing its efficacy in a very short period of time.
In diverse studies it has been shown the activity of allicin, however its little stability has been a limitation in its possible therapeutic applications.

Method used

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  • Antiseptic, antiseborrheic, exfoliating composition for getting rid of or preventing acne
  • Antiseptic, antiseborrheic, exfoliating composition for getting rid of or preventing acne

Examples

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Effect test

example 1

[0059]An antimicrobial and antiseptic hydrosoluble composition was prepared containing:

ComponentKga-hydroxyethanoic acid57.1DDMO4Sodium lauryl sulfate50Sodium lauryl ether sulfate50Glycerin2.5Blue fragrance3Purified water333.4

example 2

[0060]A second composition was prepared containing the following elements:

ComponentKga-hydroxyethanoic acid58DDMO5Sodium lauryl sulfate40Sodium lauryl ether sulfate60Ethylene glycol2.5Floral fragrance3Purified water331.5

example 3

[0061]A third example of the object compositions of the present invention is shown, thus proving that the embodiments of the same only limit to preserving the homogeneous distribution aspects of all components.

ComponentKga-hydroxyethanoic acid57.1DDMO4Sodium lauryl ether sulfate100Sorbitol2Blue fragrance3Purified water-ethanol (9:1)333.9

Clinical Trials:

[0062]A clinical trial was made applying the product of the present invention (example 1) during 28 days to 20 patients with moderate acne, according to the classification shown in Table 3 below.

TABLE 3Grade*Description0Clean skin with no inflammatory or non-inflammatory wounds1Almost clean; Little non-inflammatory wounds and no more tantwo inflammatory wounds2Middle severity; greater than grade 1; some non-inflammatorywounds, few inflammatory wounds (only papules / pustules;no nodular wounds)3Moderate severity; greater than grade 2; many non-inflammatorywounds and several can be inflammatory, but no more than twonodular wounds.4Severe;...

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Abstract

The invention refers to an antimicrobial, exfoliating and seboregulating hydrosoluble composition comprising a combination of diallyl disulphide modified oxide (DDMO) and alpha hydroxyethanoic acid (glycolic acid), which acts removing bacteria affecting the skin including those caused by acne, said composition also provides deep cleansing, exfoliating action, reduces epidermal cohesion facilitating cellular change, preventing the occurrence of several forms of acne in the skin and additionally producing seboregulating effects by avoiding blockage of sebaceous glands.

Description

FIELD OF THE INVENTION[0001]The present invention relates to a hydrosoluble pharmaceutical antiseptic, antiseborrheic and exfoliating composition comprising a combination of diallyl disulphide modified oxide (DDMO) and alpha hydroxyethanoic acid (glycolic acid) to remove bacteria affecting the skin, besides said composition provides a deep cleansing because it reduces the epidermal cohesion and facilitates the cellular replacement, preventing or removing the occurrence of several forms of alterations in the skin.BACKGROUND OF THE INVENTION[0002]The skin has a microbial flora, which can be affected by changes in normal conditions of the skin, more likely acne is the most frequency of these alterations, due to the multiple factors altering it and producing a balance loss of the microbial flora.[0003]Acne is an inflammatory illness of the pilosebaceous follicles, associated to the keratinization and seborrhea alterations; characterized by the formation of skin wounds such as: blackhead...

Claims

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Application Information

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IPC IPC(8): A61K31/191A61K31/10
CPCA61K8/365A61K8/46A61K31/10A61Q17/005A61Q19/008A61Q19/10A61K2800/28A61K31/191A61P17/00A61P17/08A61P17/10A61P31/02A61P31/04Y02A50/30
Inventor MAGANA CASTRO, JOSE AGUSTIN ROGELIOVAZQUEZ CERVANTES, LAURAPENA SANTOYO, PEDRO
Owner EXCALIBUR PHARM INC
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