Compositions for improving skin conditions comprising veratric acid or acceptable salt thereof as an active ingredient

a technology of veratric acid and active ingredient, which is applied in the direction of biocide, drug composition, hair cosmetics, etc., can solve the problems of side effects, severe hormonal imbalance conditions, and problems in stability and safety, and achieve the effects of reducing skin wrinkles, promoting hair growth, and preventing hair loss

Inactive Publication Date: 2015-10-08
BIOSPECTRUM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0067]As described above, the inventive cosmetic, pharmaceutical, and food composition containing veratric acid or acceptable salt thereof as an active ingredient has the effect of protection from UV rays, the reduction of skin wr

Problems solved by technology

Due to environmental pollution, car exhaust gases and the like, hormone imbalance conditions are becoming severe.
The above methods have an insignificant effect on the alleviation of wrinkles, or when they are excessively used, they cause side effects and are problematic in terms of stability and safety.
Finasteride is excellent in terms of convenience and efficacy, but has a problem in that it is prepared using expensive or highly toxic reagents, which increase the production cost or caus

Method used

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  • Compositions for improving skin conditions comprising veratric acid or acceptable salt thereof as an active ingredient
  • Compositions for improving skin conditions comprising veratric acid or acceptable salt thereof as an active ingredient
  • Compositions for improving skin conditions comprising veratric acid or acceptable salt thereof as an active ingredient

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of Hair Growth Agent

[0076]A hair growth agent containing varatric acid was prepared as a hydrogel base having the component and contents shown in Table 1 below. Concretely, an aqueous phase comprising purified water was dissolved by heating to 70° C., and oil phase comprising a preservative and a thickener was dissolved by heating to 70° C., thus preparing an emulsion using homixer (Tokushu Kika, Japan). Then, the emulsion was cooled to 45° C., and veratric acid was added to an amount of 0.1 and 1.0 wt % on the total weight of the composition and dispersed in the cooled emulsion, followed by cooling to 30° C. In Table 1, test groups 1 and 2 are hair growth agent containing veratric acid.

TABLE 1Content (%)ComponentTest group 1Test group 2Veratric acid0.11.0Preservative (Gramben)0.50.5Thickener (xanthan-gum)0.30.3Purified water99.198.2Total weight100100

example 2

Measurement of Effects on Hair Growth and Hair Loss Prevention of Veratric Acid

[0077]2-1. Measurement of Effects on Hair Growth and Hair Loss Prevention Under Invitro-Conditions

[0078]Human hair follicle dermal papillar cells (Application, Inc., USA) were seeded into a 6-well micro plate containing DMEM medium (Gibco, USA) with FBS at a density of 3×105 cellsper well, and then were cultured in a 5% CO2 in cubator at 37° C. for 24 hours. The next day, the cells were washed once with serum-free medium, and the medium was replaced with serum-free medium. Then, the cells were treated with 0, 10 and 100 μM of veratric acid, followed by incubating for 72 hours, after which the cells were washed once with serum-free medium, the medium was replaced with serum-free medium containing 10% MTT, and after 3 hours, the optical density (O.D.) value was measured and calculated as a percentage of control. The results are shown in FIG. 1.

[0079]As a result, veratric acid increased the proliferation of ...

example 3

Measurement of Effects of Veratric Acid on Inducing Growth Factor IGF-1

[0088]Human hair follicle dermal papillar cells (Application, Inc., USA) were seeded into a 24-well micro plate at density of 7.5×104 cellsper well, and then were cultured in a 5% CO2 incubator at 37° C. for 24 hours. Then, the medium was replaced with serum-free medium, followed by being cultured for 16 hours. Then, each well was treated with 0, 10 and 100 μM of veratric acid, after which the cells were incubated for 48 hours. Then, the cell culture media were collected.

[0089]The secretion rate of growth factor insulin-like growth factor-1 (IGF-1) was determined by measuring the amount of secretion rate of IGF-1 using Insulin-like growth factor-1 quantikine ELISA kit (DG100, R&D system, USA). The results are shown in FIG. 2.

[0090]As a result, veratric acid increased the IGF-1 secretion of human hair follicle dermal pailla cells in a concentration-dependent manner.

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Abstract

The present invention relates to a cosmetic, pharmaceutical, and food compositions comprising veratric acid or acceptable salt thereof as an active ingredient. The composition of the present invention has an excellent effect of reducing skin wrinkles through molecular mechanisms including the promotion of collagen synthesis and inhibition of collagenase activity. Also, the composition of the present invention has an excellent effect of reducing wrinkles by absorbing UVB to prevent UV rays from penetrating the skin, promotion of collagen synthesis and inhibition of collagenase activity. In addition, the composition of the present invention has effect of promotion of hair growth and the prevention of hair loss through growth promotion of hair dermal papilla cells, stimulation of IGF-1 secretion, and inhibition of TGF-beta1 secretion. Also, because the composition of the invention is derived from plants such as natural materials, it is harmless to the human body and can be safely applied to cosmetic, pharmaceutical, and food compositions.

Description

TECHNICAL FIELD[0001]The present invention relates to a composition comprising veratric acid or acceptable salt thereof as an active ingredient, more particularly, which has excellent stability, can be used safely without adversely affecting the skin, and has excellent effects on blocking UV rays, reducing wrinkles, promotion of hair growth and prevention of hair loss.BACKGROUND ART[0002]Due to environmental pollution, car exhaust gases and the like, hormone imbalance conditions are becoming severe. For this reason, the incidence of hair loss is increasing, the age of people with hair loss is decreasing, and various skin diseases are being caused due to the inability of the skin immune system. Thus, extensive studies have been conducted to develop materials that can provide a beautiful appearance and can effectively solve various phenomena that are serious social problems, for example, wrinkle formation by intrinsic aging and UV rays, immune imbalance, and hair loss.[0003]Wrinkles a...

Claims

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Application Information

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IPC IPC(8): A61K8/368A23L1/30A61Q7/00A61Q19/08A61Q17/04
CPCA61K8/368A61Q19/08A61Q17/04A23V2002/00A23L1/3002A61K2800/92A61Q7/00A61Q19/00A23L33/105A61P17/14A61P17/16A61K8/02A61K8/36A61K8/06A61K2800/48A61K2800/524A61K2800/74
Inventor SHIN, SEOUNG WOOJUNG, EUN SUNPARK, DEOK HOON
Owner BIOSPECTRUM
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