Bioinert article and its use

a bioinert and article technology, applied in the field of articles, can solve the problems of improper device function in vivo and in vitro, cell adhesion, irritation of surrounding tissue, etc., and achieve the effect of enhancing the ingrowth of a permanent implant into the surrounding tissue and increasing specific interactions

US20160222224A1Active Publication Date: 2016-08-04FREE UNIV OF BERLIN
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
Publication Date
2016-08-04

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Abstract

An article, comprising a substrate and a polymer film attached to the substrate is provided, the polymer film comprising a first layer of a first polymer functionalized by a first functionalization compound covalently bound to said first polymer and bearing at least one catecholic group being present on a surface of the first layer. The polymer film is a layered film, a top layer of which is formed by the first layer, the layered film comprising at least one further layer of at least one further polymer functionalized by a further functionalization compound covalently bound to said further polymer and bearing at least one catecholic group being present on a surface of the at least one further layer, wherein an average ratio of catecholic groups per polymer molecule is equal to or less than 1 in case of the first polymer and greater than 1 in case of the further polymer.
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Description

CROSS-REFERENCE TO A RELATED APPLICATION

[0001] This application is a National Phase Patent Application of International Patent Application Number PCT / EP2014 / 069091, filed on Sep. 8, 2014, which claims priority of European Patent Application Number 13184328.6, filed on Sep. 13, 2013.BACKGROUND

[0002] The invention relates to an article.

[0003] An article as described herein has a surface that is modified in order to reduce protein and cell adhesion and can thus be described as antifouling-coated surface.

[0004] Biofouling on material surfaces in the biological, medical or diagnostic field is a major problem that can result in inflammation, cell adhesion, irritation of the surrounding tissue, and improper function of devices in vivo and in vitro [1, 1a, 2]. Therefore, improving the bioinert and antifouling ability of material surfaces in contact with biofluids plays an important role, e.g. in medical engineering. Medical implants for example are manufactured from diverse material classes in ...

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Embodiment Construction

[0107]FIG. 1A is a schematic depiction of the steps to be performed in order to produce an article coated with an antifouling-coating of a two-layered polymer film 1 on a metal substrate 2. For building up the polymer film 1, a multiple catechol-functionalized hyperbranched polyglycerol (hPG) 4 with a degree of functionalization of 10% (hPG-Cat10) is produced in a first step from hPG and a functionalization compound bearing a catecholic group. This hPG-Cat10 4 was developed to form an inert foundation layer 3a which can effectively shield metals, metal oxides and other substrates. The foundation layer 3a can also be referred to as lowest polymer layer of the layered polymer film 1. The foundation layer 3a is a multi-molecular layer in which the individual catechol-functionalized polyglycerols 4 (which serve as second or further polymer) are cross-linked to each other via their catechol groups. In addition, the catechol groups of the polymer 4 of the foundation layer 3a serves for an...