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Methods and compositions for reducing damage associated with oxidative phosphorylation

Inactive Publication Date: 2018-01-11
USANA HEALTH SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes a nutritional supplement that can help reduce damage caused by free radicals. The supplement contains a mixture of compounds that can increase the body's own antioxidant systems. This mixture includes alpha lipoic acid, resveratrol, curcumin, EGCG, Olivol®, rutin, quercetin, and hesperetin. The supplement also contains a mixture of carotenoids, vitamins, and minerals. The nutritional supplement can be taken in pill or tablet form. By taking this supplement for a few days, it can help reduce the amount of damage caused by free radicals in the body.

Problems solved by technology

These nutrients often include compounds such as vitamins that are vital for growth and development but cannot be produced by the body.
For example, while conventional nutritional supplements may provide exogenous antioxidants, conventional nutritional supplements do not spur the body to upregulate its own endogenous antioxidant systems.
Also, while conventional nutritional supplements may provide exogenous antioxidants, the conventional nutritional supplements are not configured to provide the long-lasting benefit of an increase in endogenous antioxidants.
Thus, while some conventional nutritional supplements currently exist, challenges still exist, including those listed above.

Method used

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  • Methods and compositions for reducing damage associated with oxidative phosphorylation
  • Methods and compositions for reducing damage associated with oxidative phosphorylation
  • Methods and compositions for reducing damage associated with oxidative phosphorylation

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0135]Various receptor assays were carried out for test compounds corresponding to ingredients of the nutritional supplement composition. In general, the receptor assays utilized reporter cells that either expressed a native receptor or a receptor hybrid. The receptor hybrids were engineered so that the native N-terminal DNA binding domain (DBD) was replaced with a yeast Gal4 DBD. The reporter cells expressed a hybrid receptor comprising either the native receptor (Nrf2 and NF-κB) or the N-terminal Gal4 DNA binding domain fused to the ligand binding domain of the specific human nuclear receptor (PPARα, PPARδ, and PPARγ). The reporter gene (e.g., firefly luciferase) was functionally linked to either upstream receptor-specific response elements (GRE) or the Gal4 upstream activation sequence (UAS). A summary of the receptors, the reporter cells used for each particular receptor assay, and the reference compounds used to confirm performance of the receptor assays are indicated below in ...

example 2

[0149]Phenotypic screening with a specialized strain of C. elegans worm was carried out using two test formulations of the disclosed nutritional supplement compositions to assess their effect on epigenetic anti-ageing activity. A first test formulation comprised the composition as described below in Table 9B and other inert ingredients and was labeled as “N356.” A second test formulation comprised a combination of alpha lipoic acid, resveratrol, curcumin, EGCG, Olivol®, rutin, quercetin, and Hesperetin as described below in Table9C and was labeled as “N357.” Each test formulation was tested over a range of concentrations. Dilutions of the test formulations were applied to individual populations of C. elegans and the lifespan of each population was monitored. Any changes in the lifespan of an individual population compared to a control population were recorded and correlated to the respective test formulation (N356 or N357) and the respective dilution (0.1 mg / ml, 1 mg / ml, and 10 mg / m...

example 3

[0160]Phenotypic screening was carried out as described in EXAMPLE 2 for various individual compounds of the N357 formulation. Individual compounds were assayed to determine any possible individual contribution that an individual compound may have to overall anti-ageing activity. Solutions of resveratrol, alpha lipoic acid, hesperidin (hesperetin), quercetin, and rutin hydrate were prepared at concentrations of 0.1 mg / ml and 10 mg / ml in DMSO. Resveratrol was sourced from Sigma Aldrich at ≧99% HPLC purity and was assigned a sample number of N108. Alpha lipoic acid was sourced from PureBulk USA as a racemic mix of R and S stereoisomers and was assigned a sample number of N198. Hesperidin was sourced from Sigma Aldrich at ≧80% purity and was assigned a sample number of N347. Quercetin was sourced from Tocris Bioscience at ≧98% HPLC purity and was assigned a sample number of N104. Rutin hydrate was sourced from Sigma Aldrich at ≧94% HPLC purity and was assigned a sample number of N346. ...

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Abstract

A composition for reducing damage associated with oxidative phosphorylation. The composition comprises an upregulating compound mixture configured to upregulate an endogenous antioxidant system, an exogenous antioxidant mixture configured to inhibit oxidation of biomolecules by reactive oxygen species, and a mineral mixture configured to provide one or more cofactors to a endogenous antioxidant enzyme. The endogenous antioxidant system includes a Nrf2 transcription factors that promotes transcription of antioxidant genes.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Patent Application No. 62 / 359,106 (Attorney Docket No. 11224.33), filed Jul. 6, 2016, entitled “METHODS AND COMPOSITIONS FOR UPREGULATING ENDOGENEOUS ANTIOXIDANT SYSTEMS,” and claims priority to U.S. Provisional Patent Application No. 62 / 359,113 (Attorney Docket No. 11224.34), filed Jul. 6, 2016, entitled “METHODS AND COMPOSITIONS FOR REDUCING DAMAGE ASSOCIATED WITH OXIDATIVE PHOSPHORYLATION,” and claims the benefit of U.S. Provisional Patent Application No. 62 / 359,120 (Attorney Docket No. 11224.35), filed Jul. 6, 2016, and entitled “METHODS AND COMPOSITIONS FOR SUPPORTING ENDOGENOUS SYSTEMS RELATED TO LIFE SPAN,” the entire disclosures of which are hereby incorporated by reference.BACKGROUND[0002]This disclosure pertains to methods and compositions for reducing damage associated with oxidative phosphorylation. More particularly, it pertains to nutritional supplements configured to upre...

Claims

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Application Information

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IPC IPC(8): A61K31/385A61K31/714A61K31/7048A61K31/593A61K31/525A61K31/519A61K31/51A61K31/455A61K31/4415A61K31/4188A61K31/375A61K31/355A61K31/353A61K31/232A61K31/197A61K31/14A61K31/122A61K31/12A61K31/05A61K31/047A61K31/015A61K31/01A61K9/20A61K36/63A61K36/82
CPCA61K31/385A23V2002/00A61K31/12A61K31/353A61K36/63A61K9/20A61K31/7048A61K31/015A61K31/232A61K31/375A61K31/355A61K31/593A61K31/122A61K31/51A61K31/525A61K31/455A61K31/4415A61K31/519A61K31/714A61K31/4188A61K31/197A61K36/82A61K31/047A61K31/14A61K31/01A23L33/15A23L33/155A23L33/40A23L33/16A61K31/05A61K9/2054A61K9/2059A61K31/065A61K31/352A61K31/382A61K45/06A23L33/10A61K2300/00A23V2200/30A23V2250/02A23V2250/032A23V2250/156A23V2250/1578A23V2250/161A23V2250/1642A23V2250/18A23V2250/2112A23V2250/21164A23V2250/21168A23V2250/2117A23V2250/213A23V2250/2131A23V2250/314A23V2250/641A23V2250/70A23V2250/702A23V2250/704A23V2250/712A23V2250/714A61K47/551
Inventor BROWN, MARKCUOMO, JOHNTIAN, JEREMY
Owner USANA HEALTH SCI
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