Methods and compositions for reducing damage associated with oxidative phosphorylation

Abstract

A composition for reducing damage associated with oxidative phosphorylation. The composition comprises an upregulating compound mixture configured to upregulate an endogenous antioxidant system, an exogenous antioxidant mixture configured to inhibit oxidation of biomolecules by reactive oxygen species, and a mineral mixture configured to provide one or more cofactors to a endogenous antioxidant enzyme. The endogenous antioxidant system includes a Nrf2 transcription factors that promotes transcription of antioxidant genes.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Patent Application No. 62 / 359,106 (Attorney Docket No. 11224.33), filed Jul. 6, 2016, entitled “METHODS AND COMPOSITIONS FOR UPREGULATING ENDOGENEOUS ANTIOXIDANT SYSTEMS,” and claims priority to U.S. Provisional Patent Application No. 62 / 359,113 (Attorney Docket No. 11224.34), filed Jul. 6, 2016, entitled “METHODS AND COMPOSITIONS FOR REDUCING DAMAGE ASSOCIATED WITH OXIDATIVE PHOSPHORYLATION,” and claims the benefit of U.S. Provisional Patent Application No. 62 / 359,120 (Attorney Docket No. 11224.35), filed Jul. 6, 2016, and entitled “METHODS AND COMPOSITIONS FOR SUPPORTING ENDOGENOUS SYSTEMS RELATED TO LIFE SPAN,” the entire disclosures of which are hereby incorporated by reference.BACKGROUND[0002]This disclosure pertains to methods and compositions for reducing damage associated with oxidative phosphorylation. More particularly, it pertains to nutritional supplements configured to upre...

AI Technical Summary

Benefits of technology

[0007]The present application discloses compositions and methods for upregulating endogenous antioxidant systems. In some embodiments, the compositions include a nutritional supplement for reducing free radical damage that comprises an upregulating compound mixture configured to upregulate an endogenous antioxidant system, an exogenous antioxidant mixture; and a mineral mixture. The upregulating compound mixture can include one or more of alpha lipoic acid, resveratrol, curcumin, EGCG, Olivol®, rutin, quercetin, and hesperetin. The exogenous antioxidant mixture can comprise one or more of mixed carotenoids, beta carotene, retinyl acetate, vitamin C, vitamin D3, vitamin E, mixed tocopherols, vitamin K1, vitamin K2, vitamin B1, vitamin B2, niacin, niacinamide, vitamin B6, folic acid, vitamin B12, biotin, pantothenic acid, inositol, choline bitartrate, coenzyme Q-10, lutein, and lycopene.

[0008]In some embodiments, the nutritional supplement comprises a first vehicle comprising an upregulating compound mixture configured to upregulate an endogenous antioxidant system and an exogenous antioxidant mixture and a second vehicle comprising a mineral mixture. The first and second vehicle can comprise a single solid tablet. The upregulating compound mixture can include o

Problems solved by technology

These nutrients often include compounds such as vitamins that are vital for growth and development but cannot be produced by the body.

For example, while conventional nutritional supplements may provide exogenous antioxidants, conventional nutritional supplements do not spur the body to upregulate its own endogenous antioxidant systems.

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