Sheet of biological tissue, tubular structure obtained from said sheet, and artificial blood vessel comprising said tubular structure

a biological tissue and tubular structure technology, applied in the field of biological tissue and tubular structure obtained from the sheet, can solve the problems of inability to avoid, significant burden on the patient's body, inevitable variability in the length and quality of the blood vessel, etc., and achieves excellent pressure resistance and handleability, no peeling or curling readily, and increase flexibility

Inactive Publication Date: 2018-10-18
ADEKA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0024]The present invention allows the provision of a sheet of biological tissue for obtaining a tubular structure having excellent pressure resistance and handleability. By an increase in flexibility, a tapered portion becomes firmly adhered and does not peel off or curl readily. Accordingly, the sheet of the present invention exhibits excellent processability. Further, a tubular structure that has excellent pressure resistance and handleability can be provided. An artificial blood vessel can likewise be provided, which exhibits excellent pressure resistance and handleability, and in which occurrence of thrombi is suppressed.

Problems solved by technology

However, invasive collection cannot be avoided when using one's own blood vessel, which accordingly translates into a significant burden on the patient's body and into inevitable variability in the length and quality of the blood vessel, although the variability differs from patient to patient and from case to case.
Furthermore, in cases of reoperation, it is impossible to obtain again patients' own blood vessels as they are already in use.
However, an artificial blood vessel made from such synthetic resins cannot be used on account of early thrombus formation or intima thickening, in a case where the artificial blood vessel is used in small-diameter blood vessels such as the coronary arteries.
The usefulness of this approach is low in surgery that must be performed in an emergency.
Moreover, the endothelial cells that cover the blood vessel lumen peel-off readily, which may give rise to thrombi.
When the cross-section of the tubular structure is thus shaped, localized pressure acts on the portion that juts out when blood flows therethrough; as a result, peel-off may occur and thus the pressure resistance of the blood vessel is insufficient.
Increasing the thickness of the sheet in order to secure pressure resistance entails poorer handleability during surgery.
Moreover, it is considered that platelets and the like adhere to the portion jutting out more easily, which is likely to result in a thrombus.

Method used

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  • Sheet of biological tissue, tubular structure obtained from said sheet, and artificial blood vessel comprising said tubular structure
  • Sheet of biological tissue, tubular structure obtained from said sheet, and artificial blood vessel comprising said tubular structure
  • Sheet of biological tissue, tubular structure obtained from said sheet, and artificial blood vessel comprising said tubular structure

Examples

Experimental program
Comparison scheme
Effect test

example 1

Production of Tubular Structure No. 1

(Sheet Formation Step, Decellularization Step)

[0096]A porcine aorta was purchased from a slaughterhouse, and was transported at 4° C. The adventitia was completely stripped off the aorta, which was then cut open. The aorta thus cut open was then cut out to a substantially rectangular shape having a length of 170 millimeters and a width of 27 millimeters. The obtained sheet was subjected to a high hydrostatic pressure treatment for 15 minutes at 100 MPa in a high pressure processing device for research and development (Dr. CHEF, by Kobe Steel, Ltd.), using saline as a medium. The treated sheet was shaken for 96 hours at 4° C. in saline containing 20 ppm of the nucleolytic enzyme DNase, followed by a treatment for 72 hours at 4° C. in 80% ethanol, and was lastly washed for 2 hours at 4° C. in saline, to yield a decellularized porcine aorta sheet.

[0097]

[0098]The thickness of the decellularized porcine aorta sheet thus obtained was 258 micrometers. A...

example 2

Production of Tubular Structure No. 2

[0104]A tubular structure No. 2 of the present invention was obtained in accordance with the same procedure as in Example 1, but herein the thickness of the decellularized porcine aorta sheet was 217 micrometers, and the incidence angle of the blade was adjusted to modify the taper angle during formation of the tapered portion. The taper angle of the obtained tubular structure No. 2 was measured in the same way as in Example 1, and a pressure resistance test and a handleability test were also carried out. The results are given in Table 1.

example 3

Production of Tubular Structure No. 3

[0105]A tubular structure No. 3 of the present invention was obtained in accordance with the same procedure as in Example 1, but herein the thickness of the decellularized porcine aorta sheet was 275 micrometers, and the incidence angle of the blade was adjusted to modify the taper angle during formation of the tapered portion. The taper angle of the obtained tubular structure No. 3 was measured in the same way as in Example 1, and a pressure resistance test and a handleability test were also carried out. The results are given in Table 1.

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Abstract

A sheet of biological tissue which includes on at least one side tapered edge portion thinning down in the thickness direction, towards an end thereof, a tubular structure obtained from the sheet, and an artificial blood vessel made up of the tubular structure are provided.

Description

TECHNICAL FIELD[0001]The present invention relates to a sheet of biological tissue and to a tubular structure obtained from the sheet, and relates to a sheet and a tubular structure that are appropriately used in artificial blood vessels or the like.BACKGROUND ART[0002]Blood vessel grafts are utilized to construct blood vessels for bypass surgery, and implement the repair or replacement of damaged or morbid blood vessels.[0003]For instance, patients' own blood vessels yield appropriate replacement grafts in atherosclerosis of coronary arteries and peripheral blood vessels, and, for example, one's own internal thoracic artery, radial artery or saphenous vein is used in affected areas each having a diameter smaller than 5 mm. However, invasive collection cannot be avoided when using one's own blood vessel, which accordingly translates into a significant burden on the patient's body and into inevitable variability in the length and quality of the blood vessel, although the variability ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61L27/36A61F2/06
CPCA61L27/3625A61F2/06A61F2210/0076A61F2240/001A61L27/507A61L27/3683A61F2230/0069
Inventor HIWATARI, KEN-ICHIROYAMAGUCHI, YUKIMURA, TAKUYATASAKI, AKIKO
Owner ADEKA CORP
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