System and method for treating inflammation

a technology of bioelectric control and inflammation, applied in the field of medical devices, can solve the problems of not showing any beneficial effects, no effective treatment for concussion, and nsaids may not be the best pharmacotherapy for managing the neurobiological factors underlying concussion injuries, so as to avoid the detrimental effects of chronic inflammation and promote positive inflammation

Active Publication Date: 2019-01-24
LEONHARDT VENTURES LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0026]Provided are a system and methods designed to promote positive inflammation in moderation, which is essential for healing and when the body is ready to turn off the inflammatory cycle loop to avoid the detrimental effects of chronic inflammation.

Problems solved by technology

To date, no effective treatment for a concussion exists.
However, evidence exists to suggest that NSAIDs may not be the best pharmacotherapy for managing the neurobiological factors underlying concussive injuries.
Other NSAIDs, such as minocycline, are able to reduce apoptotic damage in several forms of CNS injury, such as spinal cord injury, but do not show any beneficial effects when examining recovery times from mild TBI.
Taken together, these data demonstrate that preventing an inflammatory response to a concussion is likely not a viable treatment.
Unfortunately, targeting this metabolic cascade has failed to produce viable treatment options.
However, general anti-inflammatory drugs will not serve as a “magic bullet.” Rather, it seems that a tailored array of pro- and anti-inflammatory compounds given at particular temporal intervals will likely be implemented given the complexity of the inflammatory response to concussion.

Method used

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  • System and method for treating inflammation
  • System and method for treating inflammation
  • System and method for treating inflammation

Examples

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Example

Controlling Expression of Follistatin

[0247]Low voltage pulsed electrical stimulation device for controlling expression of follistatin, a muscle formation promotion protein, from tissues.

[0248]Epicardial stimulation is especially useful for heart regeneration.

[0249]In one embodiment, the system stimulates the controlled production / release of follistatin, a known myostatin inhibitor, thus promoting the formation of new muscle and repair of damaged or weakened muscle including heart muscle post heart attack. Follistatin-like 1 (FSTL1) is a protein that encourages the growth of healthy cells, contractile muscle tissue and even blood vessels, helping supply the newly created muscle tissue with oxygen and nutrients. This therapy was originally designed to reduce or eliminate scarring of the heart following a heart attack and reversing heart failure, but may also be applicable to treating other organs suffering from muscle loss or degradation.

[0250]The electrical stimulation device ...

example

[0340]In bioelectric stimulation tissue studies, a 2000% and increase in IL-6was achieved.

[0341]IL-6 is a key promoter of regeneration. With respect to IL-6, Mosteiro et al. (2016) shows that tissue damage is a relevant factor for cells to go back to an embryonic state. Nobel Prize winner Shinya Yamanaka opened the door to regenerative medicine by cell reprogramming, based on introducing a combination of four genes known as OSKM (for genes, OCT4, SOX2, KLF4, and MYC), which reverts adult cells to an embryonic-like state, and transforms these cells into pluripotent cells. Cell reprogramming was later achieved within a living organism (i.e., a mouse) in 2013.

[0342]Mosteiro et al. (2016) analyzes what happens in living tissues when reprogramming is induced using OSKM. OSKM was found to be inefficient at inducing reprogramming or pluripotency in the highly specialized cells that constitute adult tissues. Tissue damage plays a critical role by complementing the activity of the OSKM genes...

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Abstract

Described is a low voltage, pulsed electrical stimulation device for reducing inflammation in a subject, which can be useful in the treatment of concussions, traumatic brain injury, cancer, and so forth.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation-in-part of U.S. patent application Ser. No. 15 / 812,760, filed Nov. 14, 2017, which is a continuation-in-part of U.S. patent application Ser. No. 15 / 460,129, filed on Mar. 15, 2017, which itself claims the benefit under 35 U.S.C. § 119 of:[0002]U.S. Provisional Patent Application Ser. No. 62 / 308,702, filed Mar. 15, 2016;[0003]U.S. Provisional Patent Application Ser. No. 62 / 363,012, filed Jul. 15, 2016;[0004]U.S. Provisional Patent Application Ser. No. 62 / 364,472, filed Jul. 20, 2016;[0005]U.S. Provisional Patent Application Ser. No. 62 / 375,271, filed Aug. 15, 2016;[0006]U.S. Provisional Patent Application Ser. No. 62 / 385,124, filed Sep. 8, 2016;[0007]U.S. Provisional Patent Application Ser. No. 62 / 454,521, filed Feb. 3, 2017; and[0008]U.S. Provisional Patent Application Ser. No. 62 / 352,930, filed Jun. 21, 2016, the disclosure of each of which is incorporated herein in its entirety by this reference.FIELD[...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N1/36A61M5/142A61N1/362A61H39/00A61K35/28A61K38/18A61K38/19A61K38/20
CPCA61N1/36031A61M5/14276A61N1/36139A61N1/3629A61H39/002A61K35/28A61K38/18A61K38/191A61K38/1841A61K38/204A61K38/2066A61K38/2006A61K38/195A61H2201/165A61M39/0208A61N1/37205A61M2039/0036A61M2202/07A61M2205/05A61M2205/50A61M2205/502A61N1/36002A61B5/026A61B5/0533A61B5/055A61B5/14542A61B5/14546A61B5/4082A61B5/4088A61B5/6803A61N1/3627A61B5/369
Inventor LEONHARDT, HOWARD J.
Owner LEONHARDT VENTURES LLC
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