Faecalibacterium prausnitzii strains for treating and preventing gastrointestinal pain

a technology of gastrointestinal pain and faecalibacterium prausnitzii, which is applied in the field of faecalibacterium prausnitzii strains for treating and preventing gastrointestinal pain, can solve the problems of ibs being poorly understood, affecting the effect of gastrointestinal pain, and the current treatment of ibs and visceral abdominal pain is disappointing

Inactive Publication Date: 2019-12-19
INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM) +4
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0042]FIG. 3A illustrates the effect of F. prausnitzii CNCM I-4573 strain on the number of abdominal cramps/5 minutes in Partial Restraint Stress (PRS) (PRS-4573—continuous slashed line; n=12 rats) or basal rats models (Basal-4573—continuous lines with circles; n=12 rats) compared to PRS or basal rats treated with PBS (respectively PRS-PBS—dotted slashed lines and Basal-PBS—dotted lines with circles; n=18 rats per group), depending on the Distension volume (mL) generated with an arterial embolectomy catheter introduced into the rectum of the rats.
[0043]FIG. 3

Problems solved by technology

However, the mechanisms by which these changes lead to IBS remain poorly understood.
This common complaint is a crucial feature because of its significant imp

Method used

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  • Faecalibacterium prausnitzii strains for treating and preventing gastrointestinal pain
  • Faecalibacterium prausnitzii strains for treating and preventing gastrointestinal pain
  • Faecalibacterium prausnitzii strains for treating and preventing gastrointestinal pain

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examples

[0118]F. prausnitzii strains according to the invention have been tested for their ability to have a direct impact on visceral pain, and more particularly on colonic hypersensitivity.

[0119]Bacterial Strains Isolation and Growth Conditions

[0120]The F. prausnitzii strains isolates used in the present example all are of human fecal origin from healthy patients. Said isolates were obtained from the highest countable dilution of human fecal samples in roll tubes of anaerobic M2GSC medium as discussed in Lopez-Sites et al. (Appl. Environ Microbiol. 2012; 78:420-428).

[0121]Tested F. prausnitzii strains isolates were grown in LYBHI medium (Brain-Heart infusion medium supplemented with 0.5% yeast extract) (Dyfco, Detroit, USA) supplemented with 1 mg / mL cellobiose (Sigma-Aldrich Chemie Gmbh, Buchs, Switzerland), 1 mg / mL maltose (Sigma-Aldrich) and 0.5 mg / mL cysteine (Sigma-Aldrich) at 37° C. in anaerobic chamber.

[0122]A. In a first series of tests, a Neonatal Maternal Separation (NMS) colonic...

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Abstract

The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual. The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.

Description

FIELD OF THE INVENTION[0001]The present invention concerns Faecalibacterium prausnitzii strains for use in the treatment and prevention of visceral abdominal pain in an individual, in particular of gastrointestinal pain of non-inflammatory origin.[0002]The present invention also concerns a composition, in particular an oral composition, comprising specific Faecalibacterium prausnitzii strains as well as new Faecalibacterium prausnitzii strains per se.PRIOR ART[0003]Visceral abdominal pain, and in particular gastrointestinal pain, is a very common disorder that affects millions of people every year all over the world and is a leading cause of patient visits to clinics. Abdominal pain is present on questioning of 75 percent of otherwise healthy adolescent students (Hyams et al. J. Pediatr. 1996; 129:220) and in about half of all adults (Heading; Scand J Gastroenterol Suppl. 1999; 231:3).[0004]Such visceral pain can originate from various origins such as peptic disease, pancreatitis in...

Claims

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Application Information

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IPC IPC(8): A61K35/741A23L33/135A61P29/00
CPCA23L33/135A61P29/00A61K35/741C12R2001/01C12N1/205
Inventor LANGELLA, PHILIPPEMIQUEL, SYLVIEMARTIN ROSIQUE, REBECABERMUDEZ HUMARAN, LUISTHOMAS, MURIELSOKOL, HARRYCARVALHO, FRÉDÉRICTHEODOROU, VASSILIA
Owner INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM)
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