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Fragrance composition

Pending Publication Date: 2022-02-03
TAKASAGO INTERNATIONAL CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a method for screening substances that can mask unpleasant odors, such as skatole, indole, α-terpineol, 4-terpineol, or p-methylacetophenone odors. This method can help in development of fragrance materials or odor masking agents that can effectively mask these odors. Additionally, the method can be used to evaluate multiple odors simultaneously, reducing olfactory fatigue and individual differences. Furthermore, the method can also use antagonist candidate compounds or specific compounds conventionally used as fragrance, in combination to provide superior effects in suppressing unpleasant odors.

Problems solved by technology

However, masking effects thereof are insufficient in terms of sense.

Method used

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  • Fragrance composition
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Examples

Experimental program
Comparison scheme
Effect test

example 1

Confirmation of Response of Olfactory Receptor OR2L3 to Unpleasant Odor-Causing Substance

(1) Cloning of Olfactory Receptor Gene

[0098]A human olfactory receptor gene was obtained by cloning according to the PCR method using Human Genomic DNA: Female (Promega) based on the sequence information registered in GenBank. The N-terminal 20 amino acid residues of bovine rhodopsin were incorporated into a pME18S vector, and the obtained human olfactory receptor gene was further incorporated downstream thereof, thereby obtaining a human olfactory receptor gene expression vector.

(2) Expression of Olfactory Receptor Gene in HEK293T Cells

[0099]0.05 μg of the human olfactory receptor gene expression vector, 0.01 μg of an RTP1S vector, 0.01 μg of a firefly luciferase vector pGL4.29 containing a cAMP-responsive sequence promoter (Promega), and 0.005 μg of a Renilla luciferase vector pGL4.74 containing a thymidine kinase promoter (Promega) were dissolved in 10 μL of Opti-MEM I (gibco) to obtain a gen...

example 2

[0102]

[0103]With respect to Group A, the effect of suppressing the response of OR2L3 that strongly responded to unpleasant odors was measured by means of luciferase reporter gene assay. In luciferase reporter gene assay, skatole and Guava coeur (registered trademark) were used by being mixed with a sample. The Fold Increase value in the test in which Guava coeur was not mixed was regarded as 1, and the ratio of the Fold Increase value in the test in which Guava coeur was mixed was obtained. The results are shown in FIG. 6. The effect of concentration-dependently reducing the response of OR2L3 to skatole exerted by Guava coeur was shown.

[0104]Guava coeur in the evaluation of the effect of suppressing the response of OR2L3 was replaced by Dextramber (registered trademark), and the test was conducted in the same manner. The results are shown in FIG. 7. The effect of concentration-dependently reducing the response of OR2L3 to skatole exerted by Dextramber was shown. Similarly, Guava coe...

example 3

Evaluation of Unpleasant Odor Suppression Ability of Group A

[0107]The unpleasant odor suppression ability of test substances having activity to inhibit receptor action was confirmed by sensory evaluation. A cotton ball on which 10 μL of skatole or indole diluted 100-fold with triethyl citrate as an unpleasant odor and 1 μL of a test substance were dropped was put into a plastic bottle (OZO-40 manufactured by Takemoto Yohki Co., Ltd.). The bottle was allowed to stand at room temperature for 1 hour to sufficiently volatilize odor molecules therein. The sensory evaluation test was conducted by a panel consisting of 20 persons, who made evaluation as follows: the odor strength in the case where the unpleasant odor was dropped solely was rated as 8, and the unpleasant odor strength in the case where the test substance was mixed was rated as from 0 (the unpleasant odor is not smelled) to 10 (the unpleasant odor is smelled very strongly). The average value was calculated from obtained nume...

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Abstract

The present invention relates to a fragrance composition containing a fragrance component which suppresses response strength of at least one olfactory receptor polypeptide, which is selected from the group consisting of OR2L3 and polypeptides that comprise an amino acid sequence having at least 80% identity to an amino acid sequence of OR2L3 and are responsive to an unpleasant odor-causing substance, to the unpleasant odor-causing substance. According to a preferred embodiment of the present invention, an unpleasant odor masking composition containing, as active components, at least one antagonist against an olfactory receptor OR2L3 and a specific component among fragrances which do not exert the effect of suppressing the response of OR2L3, is provided. According to a preferred embodiment of the present invention, unpleasantness caused by at least one unpleasant odor selected from the group consisting of fecal odor, body odor, tobacco odor, breath odor and musty odor can be reduced.

Description

TECHNICAL FIELD[0001]The present invention relates to a fragrance composition containing a fragrance component which suppresses an unpleasant odor. The present invention also relates to a product containing the fragrance composition and a method for suppressing an unpleasant odor.BACKGROUND ART[0002]Recently, the population of persons sensitive to bad smells and unpleasant odors around them is growing depending on diversification of consumer preferences and living environments.[0003]Typical examples of substances that cause unpleasant odors in living spaces include skatole and indole which are contained in body odor, fecal odor, rotten odor, etc. (Patent Literature 1).[0004]Regarding techniques of selectively masking these unpleasant odors, the possibility of masking methods based on the antagonism mechanism, wherein an olfactory receptor responsive to a specific odorous substance is searched and activation thereof is suppressed by a specific substance, is becoming clear. As olfacto...

Claims

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Application Information

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IPC IPC(8): A61L9/01
CPCA61L9/01A61L2209/21A61Q13/00A61K8/64A61K8/46A61K8/35A61K8/922A61K8/37A61K8/34A61K8/498C12Q1/66G01N33/502G01N2333/705
Inventor MIHARA, HISASHIKUWAHARA, YUKARIMURAI, MASATOKOBAYASHI, TSUYOSHIISHIDA, KENYA
Owner TAKASAGO INTERNATIONAL CORPORATION
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