The invention discloses a medicine application device convenient to replace for a stomatology department. The medicine application device comprises a device body, wherein the device body comprises anupper dental cast, a lower dental cast and a regulation assembly, wherein opening grooves for containing teeth are formed in upper and lower back surfaces of the upper dental cast and the lower dentalcast, the regulation assembly is located on front surfaces of the upper dental cast and the lower dental cast and comprises a one-way screw, a nut plate and a mounting plate, the mounting plate and the nut plate are fixed to the front surfaces of the upper dental cast and the lower dental cast respectively, length-adjustable telescopic columns are fixed to front surfaces of the upper dental castand the lower dental cast, a mounting block is fixed to the lower surface of the mounting plate, one end of the one-way screw is exposed to the lower side of the nut plate, a hand wheel is fixed at one end, and the other end penetrates through the nut plate to stretch into the mounting block. By arrangement of the device, the relative distance between the upper dental cast and the lower dental cast is convenient to adjust, so that the opening degree of the mouth of a patient is changed, medicine application to interior of an oral cavity is facilitated, the workload and fatigue of a medical worker for manually opening the mouth of the patient are reduced, and the medicine application device is simple in structure and convenient to operate.