12 results about "Missing kidney" patented technology

This invention discloses a traditional Chinese medicine composition for treating male infertility due to liver stagnation and kidney deficiency, its preparation method, and its application, belonging to the fields of traditional Chinese medicine pharmaceutical technology and andrological reproductive health technology. The composition is formulated with Bupleurum chinense, Tribulus terrestris, Cynomorium songaricum, Cuscuta chinensis, Cornus officinalis, and Epimedium brevicornu in specific weight proportions, following the principles of soothing the liver and relieving stagnation, tonifying the kidney and replenishing essence, and unblocking the meridians to treat impotence. This invention employs an alcohol-water dual-phase fractional extraction process, and can be prepared into various dosage forms such as granules, capsules, and tablets. Pharmacological experiments have confirmed that the composition of this invention can increase sperm density and progressively motile sperm rate, improve penile tissue nitric oxide synthase (NOS) activity, regulate reproductive hormones, and reduce testicular oxidative damage; serum pharmacochemistry and metabolomics have clarified the active components entering the bloodstream and their pathways of action. This invention features a refined formulation, abundant medicinal resources, and simple preparation, making it suitable for large-scale production and clinical application in treating male infertility due to liver stagnation and kidney deficiency.

The present invention relates to the field of traditional Chinese medicine, and in particular to a Chinese medicine composition for tonifying the kidney, activating blood circulation and removing dampness, and its preparation and application. The present invention proposes a treatment principle of tonifying the kidney, activating blood circulation and removing dampness for the pathological mechanism of knee osteoarthritis of kidney deficiency, dampness and stasis type, combined with the clinical symptoms of patients, and emphasizes the treatment method of treating dampness and stasis at the same time, so as to prepare a Chinese medicine composition for tonifying the kidney, activating blood circulation and removing dampness, which has the effects of tonifying the kidney and strengthening the spleen, activating blood circulation and removing blood stasis, and removing dampness and removing arthralgia. The present invention objectively evaluates the clinical efficacy and safety of the Chinese medicine composition of the present invention in treating knee osteoarthritis of kidney deficiency, dampness and stasis type through a clinical randomized controlled trial study. The research results show that the Chinese medicine composition can effectively improve the clinical symptoms of patients, relieve pain, and improve the quality of life of patients. It has more significant effects in relieving joint pain, fatigue, pain anxiety, etc., and has obvious efficacy, good drug safety, no obvious adverse reactions, and has important clinical application value.

This invention relates to a topical acupoint patch, its preparation method, and its application, comprising the following raw materials in parts by weight: 45-55 parts of Cuscuta chinensis, 45-55 parts of Psoralea corylifolia, 45-55 parts of Loranthus parasiticus, 45-55 parts of Acanthopanax senticosus, 45-55 parts of Ligusticum chuanxiong, 45-55 parts of Lycopodium clavatum, and 15-25 parts of Zanthoxylum bungeanum. The topical acupoint patch of this invention has a therapeutic effect on knee osteoarthritis, especially on knee osteoarthritis of the kidney deficiency and blood stasis type.

The invention discloses a Chinese medicine composition for treating chronic renal failure, a preparation method and application thereof, and belongs to the technical field of Chinese medicine preparation. The composition is made of the following raw materials in parts by weight: 2-4 parts of Astragalus, 3-4 parts of Rhubarb Carbon, 3-4 parts of Raw Rhubarb, 1-3 parts of Chuanxiong, 1-3 parts of Psoralea corylifolia, 12-15 parts of Taraxacum, 12-15 parts of Stir-fried Cassia Seed, 1-3 parts of Citrus aurantium, and 5-7 parts of Scutellaria barbata. The invention has a scientific prescription and precise proportions, and has the effects of invigorating the kidney and activating blood circulation, lowering turbidity and detoxifying, and calming the five internal organs. It is an effective prescription for treating chronic renal failure, and is used for patients with kidney deficiency, blood stasis, and turbid toxin disturbance syndrome of chronic renal failure caused by various reasons. The Chinese medicine composition provided by the invention has a definite overall therapeutic effect, significantly reduces the serum Scr level, and has significant differences in ACR, eGFR, BUN, and Hb before and after treatment. It can significantly improve the renal function indicators of patients with chronic renal failure, delay the development of chronic kidney disease, and effectively improve the quality of life of patients.

The invention discloses a kidney-tonifying and collateral-dredging pill and a preparation method thereof.The kidney-tonifying and collateral-dredging pill is prepared from hot rhizoma drynariae, angelica sinensis, scorpio, roasted herba epimedii, ligusticum wallichii, ground beeltle, fructus lycii, vinegar frankincense, vinegar myrrh, earthworm, gastrodia elata, fried endothelium corneum gigeriae galli, ginseng and corn starch. The double effects of tonifying the kidney and dredging collaterals are achieved, and various symptoms caused by kidney deficiency are remarkably improved.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for tonifying kidney and activating blood. Under the guidance of the theory of kidney deficiency and blood stasis, the invention provides a prescription with the efficacy of tonifying kidney and promoting blood circulation, the prescription is continuously optimized clinically, and the basic composition of the prescription for tonifying kidney and promoting blood circulation is finally provided and comprises raw astragalus membranaceus, schisandra chinensis, ligusticum wallichii, salvia miltiorrhiza, rheum officinale, charred rheum officinale, dandelion and patrinia. Compared with the prior art, the traditional Chinese medicine composition has better effects of delaying or controlling renal function deterioration and delaying renal fibrosis.

The invention relates to the technical field of medicines, in particular to application of a nine-steamed nine-sun-dried polygonum multiflorum extract in preparation of a medicine for treating kidney deficiency. In the specific embodiment of the invention, a kidney yin deficiency animal model is constructed, the kidney tonifying effect of the nine-steamed and nine-sun-dried polygonum multiflorum extract is evaluated by observing the change condition of the hormone levels of HPT axis, HPA axis, HPG axis and the like after model animal administration, and the result shows that the nine-steamed and nine-sun-dried polygonum multiflorum extract can remarkably regulate the functions of the HPT axis, the HPA axis and the HPG axis and play the kidney tonifying effect, so that the effect of tonifying the kidney is achieved. The method can be used for preparing kidney-tonifying medicines. Therefore, the invention provides a scientific basis for research and development of kidney tonifying medicines. Meanwhile, the specific embodiment of the invention evaluates the hepatotoxicity of the nine-steamed and nine-sun-dried polygonum multiflorum extract by using a special liver injury model, and proves that the medication safety of the nine-steamed and nine-sun-dried polygonum multiflorum extract is superior to that of raw polygonum multiflorum.

The invention discloses an essence-nourishing and liver-soothing composition for treating kidney deficiency, liver stagnation and spleen deficiency type premature ovarian failure and a preparation method of the essence-nourishing and liver-soothing composition, and belongs to the field of traditional Chinese medicines, the essence-nourishing and liver-soothing composition is prepared from fructus corni, radix rehmanniae preparata, radix angelicae sinensis, radix paeoniae alba, rhizoma dioscoreae, pericarpium citri reticulatae, semen cuscutae, fructus ligustri lucidi, herba lycopi and rhizoma cyperi. The essence-nourishing and liver-soothing soup is based on the essence-nourishing and seed-growing soup, is added and reduced by combining clinical practice and summarized experience, is prepared to tonify kidney and replenish essence, soothe liver, regulate and tonify Chong and Ren meridians, dredge the Ren and dredge and regulate qi and blood, effectively improves the ovarian function, and further achieves the effects of regulating menstruation and assisting pregnancy. The essence-nourishing and liver-soothing soup is mainly used for premature ovarian failure patients, and prophase clinical observation shows that the essence-nourishing and liver-soothing soup has good clinical effects in the aspects of improving serum sex hormone indexes, increasing the number of sinus follicles, promoting follicle maturation and smooth discharge and improving the success rate of pregnancy.

This invention relates to a traditional Chinese medicine composition for delaying the progression of kidney deficiency and blood stasis syndrome in diabetic nephropathy, its application, and preparation method. The composition is made from Astragalus membranaceus, Salvia miltiorrhiza, Paeonia lactiflora, Anemarrhena asphodeloides, Phellodendron chinense, Cistanche deserticola, Scutellaria baicalensis, Euonymus alatus, Schisandra chinensis, raw oyster shell, Plantago asiatica, and Artemisia annua. It has the effects of nourishing the kidneys, clearing heat, eliminating toxins, and unblocking the meridians. This traditional Chinese medicine composition can effectively delay the decline in renal function in patients with massive proteinuria during the diabetic nephropathy stage, improve the clinical symptoms of patients with kidney deficiency and blood stasis syndrome, and improve their quality of life. Simultaneously, it has a low risk of hyperkalemia and gastrointestinal bleeding, and no significant damage to liver function has been observed, indicating high safety.

The invention relates to application of toyocamycin to construction of an animal model of implantation obstacles and a construction method of the animal model of implantation obstacles, and belongs to the technical field of medicines. According to the invention, a traditional Chinese medicine combination model of the SD rat implantation disorder in accordance with the kidney deficiency and blood stasis syndrome in traditional Chinese medicine is manufactured, and the requirements of traditional Chinese medicine research are met; a stable kidney deficiency and blood stasis-embryo implantation disorder rat model is manufactured, and the modeling success rate is increased; the modeling time is only 5 days from the time of confirming that the rat is pregnant, so that the modeling time is greatly reduced; operation steps are reduced, intraperitoneal injection can be completed only through one time of intraperitoneal injection, and harm to experimental animals is reduced.

The present application relates to the use of fungacin in the construction of an animal model of implantation disorder and a method for constructing an animal model of implantation disorder, and belongs to the technical field of medicine. The present application manufactures an SD rat implantation disorder TCM syndrome combination model conforming to the kidney deficiency and blood stasis syndrome type, meeting the needs of TCM research; a stable kidney deficiency and blood stasis-embryo implantation disorder rat model is manufactured, and the success rate of modeling is improved; the modeling time of the present application is only 5 days from confirming that the rat is pregnant, greatly reducing the modeling time; the operation steps are reduced, and only one intraperitoneal injection is needed to complete, reducing the harm to experimental animals.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a kidney-warming and phlegm-removing preparation for polycystic ovarian syndrome and application of the kidney-warming and phlegm-removing preparation. The kidney-warming and phlegm-cleaning preparation contains amethyst, cistanche deserticola, semen cuscutae, 5.5-22 parts by weight of rhizoma atractylodis, ginger processed pinellia, angelica sinensis, rhizoma cyperi, rhizoma acori graminei, herba epimedii and ligusticum wallichii, and can effectively improve the condition of a patient suffering from kidney deficiency and phlegm-dampness type PCOS, improve the ovarian reserve function and the serum sex hormone secretion condition of the patient and improve the curative effect of the patient. The traditional Chinese medicine composition has great advantages in the treatment of polycystic ovarian syndrome and irregular menstruation, and has good safety and wide market application prospects.