25 results about "Order Rodentia" patented technology

Disclosed is a genetically modified rodent, in which an immunoglobulin light chain locus is modified to insert a human immunoglobulin light chain gene segment. The rodent is capable of normal reproduction and of producing antibodies containing human light chains. Further provided are a method for preparing the genetically modified rodent and the use.

The present invention discloses a genetically modified rodent whose immunoglobulin light chain locus is modified so as to comprise a single rearranged human immunoglobulin light chain gene V / J gene upstream of a mouse Kappa light chain locus constant region, a mouse variable region sequence cannot bind to an endogenous constant region to form a complete mouse light chain antibody, the rodents are capable of normally reproducing and producing human light chain-containing antibodies. The invention also provides a method of making the genetically modified rodent and a use of the rodent.

To provide a humanized rodent that expresses a heavy chain containing a VL domain. [Solution] A non-human animal, tissue, cell, and genetic material is provided which includes a modification of an endogenous non-human heavy chain immunoglobulin sequence and contains functional ADAM6 activity in a rodent (e.g., mouse), wherein the non-human animal rearranges the human immunoglobulin light chain gene segment in relation to the heavy chain constant domain and expresses an immunoglobulin-like molecule which contains a human immunoglobulin light chain variable domain fused to the heavy chain constant domain and is a cognitive of a human immunoglobulin light chain variable domain fused to the light chain constant domain.

Device (1) for providing a rodenticide bait in a sewer, comprising a holding device (17) for receiving a bait, wherein the bait is freely accessible to rodents in a first position of the device (1), a protective device (7) designed to at least partially enclose the bait, a release mechanism actuated by a rising water level, wherein the protective device (7) is held in an open position in the first position by a retaining element (15), and wherein the release mechanism comprises a float (6) which releases the retaining element (15) when the water level rises, so that the protective device (7) is automatically moved into a closed position in which the bait is shielded from the surrounding water.

The application discloses a rodent mouth opener and a use method thereof, and the mouth opener comprises a sleeve, a sleeve rod, a locking nut, a U-shaped spring, a tooth buckle and a jaw pad. The sleeve, the sleeve rod and the locking nut constitute an oval mouth opener of the rodent mouth opener, the sleeve and the sleeve rod are connected into a whole through the locking nut, and the sleeve rod is convenient to adjust the mouth opener through expansion and contraction in the sleeve. The tooth buckle is connected to the middle part of the sleeve, the tooth buckle is matched with upper and lower front teeth of the rodent, and the tooth buckle is used for sleeving the front teeth of the rodent. The tooth buckle is provided with the jaw pad, the jaw pad prevents the mouth of the rodent from being hurt by being pressed, the middle part of the sleeve rod is connected with the U-shaped spring, the U-shaped spring provides elastic force to open the corners of the mouth of the rodent, and the U-shaped spring can assist in adjusting the opening degree. The application adopts a symmetrical structure design, is fixed firmly, avoids multiple adjustment of fixation and opening degrees of experimental animals caused by loosening or left-right shaking, and can adjust multiple structures to match rodent animals with different opening degrees for experiments.

To provide transgenic mammals expressing bovine-based immunoglobulins, including transgenic rodents expressing bovine-based immunoglobulins for the development of bovine therapeutic antibodies.SOLUTION: A transgenic rodent or rodent cell is provided comprising an engineered partially bovine immunoglobulin light chain locus comprising bovine immunoglobulin λ light chain variable region gene segments, wherein the engineered immunoglobulin locus is capable of expressing immunoglobulins comprising bovine variable domains, and wherein the transgenic rodent produces or is likely to produce more immunoglobulins comprising λ light chains than immunoglobulins comprising κ light chains.SELECTED DRAWING: Figure 13

Provided herein are methods and compositions related to in vivo testing of therapeutic agents comprising a human Fc in genetically modified rodents (e.g., testing the pharmacokinetic and / or pharmacodynamic properties of such therapeutic agents in genetically modified rodents). In some embodiments, the genetically modified rodents express antibodies comprising a human Fc (e.g., human IgG1 Fc, human IgG4 Fc). In some embodiments, the rodents express fully human antibodies (i.e., antibodies having human heavy chains and human light (γ or κ) chains). In certain embodiments, the genetically modified rodent comprises one or more Fc receptors with human extracellular domains (e.g., neonatal Fc receptor (FcRn), β-2-microglobulin polypeptide (β2M), Fcε receptor 1α (FcεR1α), Fcγ receptor 1α (FcγR1a), Fcγ receptor 2a (FcγR2a), Fcγ receptor 2b (FcγR2b), Fcγ receptor 3a (FcγR3a), Fcγ receptor 3b (FcγR3b), Fcγ receptor 2c (FcγR2c)). The transmembrane and cytoplasmic domains of the receptor can be human or non-human (e.g., rodent).

A live catch rodent trap comprises a housing, an entry door, a release or exit door, and a latch assembly. The housing defines a first or entry opening, and a second or release opening. The entry door selectively covers the first opening, enabling a rodent to enter an interior of the trap and to be captured therewithin. The release door is pivotally attached to the housing. The release door is, in response to actuation by a user, movable between a closed position covering the second opening, and a release position at least partially uncovering the second opening and permitting a rodent to exit the interior of the trap. The latch assembly selectively secures the release door in the closed position, and includes an actuator adapted to be engaged or biased by a user for releasing the latch assembly from a latched state.

A pest trap (1), in particular for controlling rodents, comprising a base body with an interior (3) and an entrance opening (4) leading into the interior (3), wherein a rocker (5) is arranged in the area of ​​the entrance opening (4), which is pivotably mounted about an axis of rotation (8) and has a passage (9) for a rodent and has at least a first rocker side (6) facing the entrance opening (4) with an outer surface (12) that can be walked on by a rodent and a second rocker side (7) facing the interior (3) with an inner surface (11) of the passage (9) that can be walked on by a rodent, wherein the rocker (5) is pivotable between a first position and a second position, and wherein the rocker (5) is operatively connected to a closing element of the entrance opening (4) such that when the walkable inner surface (11) is entered, the rocker (5) is pivoted into the first position.wherein the locking element closes the entrance opening (4), and when the outer surface (12) of the first rocker side (6) is entered, the rocker (5) pivots from the first position to the second position, in which the entrance opening (4) is released by the locking element.

Device for controlling rodent pests, comprising a killing agent (6, 7) and a carrier with a carrier surface that rodent pests can walk on, wherein the killing agent (6, 7) is attached to the carrier and defines an effective area extending along a section of the carrier surface frequented by rodents, the killing agent (6, 7) is oriented relative to the carrier in such a way that a rodent killed in the effective area falls away from the carrier surface by gravity and the effective area remains open for a subsequent rodent, and the killing device (6, 7) has at least one triggering device projecting into the effective area, which can be actuated by a rodent crossing the effective area to trigger a killing process, wherein the killing device (6, 7) is switchable between an activated state and a deactivated state.

The invention provides an I-type primary hyperoxaluria animal model as well as a preparation method and application thereof. Specifically, the invention provides an application of a combination of experimental materials, and the combination is used for preparing a rodent model of type I primary hyperoxaluria (PH1). A mouse model in which 3rd to 8th exons of the Agxt gene are knocked out and a specific dose of glyoxylic acid are used, so that the human disease phenotype of the type I primary hyperoxaluria can be more accurately simulated, the modeling time is greatly shortened, the research cost is reduced, and the method is suitable for popularization and application. The pathogenesis of the PH1 can be better clarified, and the searching of a PH1 immunotherapy target spot and method and the screening of a medicine for treating the PH1 are promoted.

Transgenic rodents and rodent cells expressing components of the human immune system, and their use in the generation of human T cell receptors (TCRs). Genetically modified rodents containing a TCRα gene locus with an unreorganized human TCRα variable gene segment and human TCRα constant region, and a TCRβ gene locus with an unreorganized human TCRβ variable gene segment and human TCRβ constant region. Antigen-specific CD8 for finding fully human TCR sequences with therapeutic potential. + Use of hTCR transgenic rodents that generate T cell responses.

The invention relates to the technical field of specimen manufacturing, in particular to a safe manufacturing process of a small rodent high-fidelity ecological specimen. Comprising the following steps: taking a mouse corpse, and fixing the mouse corpse on a mouse dissecting disc; dissecting the mouse, taking out organs, cutting off mouse tongues, and releasing muscles; putting the anti-corrosion powder into released muscles of the abdominal cavity, the chest, the oral cavity and the neck of the mouse, and finally filling the mouse with the anti-corrosion powder; tearing the cotton ball into a sheet shape, covering the space between the mouse chest, abdominal cavity, neck preservative powder and skin, sewing, then taking down and inserting on a foam plate, adjusting the shape, and arranging hair; and putting the modeled mouse book into a paper box, pouring anti-corrosion powder, sealing the box, air-drying, taking out the mouse book, wiping off the anti-corrosion powder, installing an artificial eye, displaying and pasting an information label, thereby finishing the manufacturing. The ecological specimen prepared through the method is vivid in form, the operation method is simple, and no chemical hazard or risk exists.

A rodent control apparatus comprising an elongated tube sized to receive a rodent (e.g., rat, mouse, etc.) at a front portion, electrocute the rodent in a middle portion, and propel the rodent's body toward a rodent disposal bag attached to a rear portion. The apparatus is configured to kill and store the remains of many rodents and, as such, finds great utility within the context of reducing a local rodent population.

The utility model relates to the technical field of rodent nose tissue pathological specimen material taking, specifically discloses rodent nasal mucosa tissue material taking device, the one side of fixed plate is provided with first fixed clamping groove and second fixed clamping groove respectively, is provided with head container on the fixed plate, is provided with first clamping groove insertion port, second clamping groove insertion port and cutting knife clamping groove on head container respectively, and the one side of head container is provided with scale, the rodent nasal mucosa tissue material taking device whole simple structure, and the installation and use are convenient, and the material taking work of rodent nasal mucosa tissue of staff is convenient, since setting up the scale for measuring distance on the bottom plate, a plurality of graduation grooves are opened on the scale, the position of rodent head tissue is measured through the scale, is convenient for its accurate cutting, thereby help to improve the accuracy of rodent nasal mucosa tissue material taking.

The present invention relates to transgenic rodents and rodent cells expressing components of the human immune system, and their use in the production of human T cell receptors (TCRs). The present invention relates to a genetically modified rodent comprising a TCR [alpha] locus and a TCR [beta] locus; wherein the TCR alpha gene locus comprises a human TCR alpha variable gene segment and a human TCR alpha constant region which are not rearranged, and the TCR beta gene locus comprises a human TCR beta variable gene segment and a human TCR beta constant region which are not rearranged. The present invention relates to the use of a human TCR transgenic rodent in the generation of antigen-specific CD8 + T cell response for discovering a fully human TCR sequence with therapeutic potential.

The present invention relates to a rodent trap (100) comprising a housing (101) with a passage (104), and a kill mechanism (150) within the housing adjacent to a kill zone (170) of the passage, arranged to be activated by a rodent within the kill zone. A first end of the passage forms a first opening (102) in the surface of the housing, and a second end of the passage forms a second opening (102) in the surface of the housing. The kill mechanism comprises a hammer (160) arranged to move into the kill zone when the kill mechanism is activated to strike a rodent within the kill zone. The ceiling of the passage is shaped such that a height of the ceiling at the kill zone (181) is higher than a height of the ceiling at the first and second openings (182a, 182b) in the surface of the housing.

Provided herein are humanized rodent models comprising a human SERPINA1 transgene, optionally wherein the rodents develop Alpha- 1 antitrypsin deficiency (A1ATD). Further provided herein are methods related to the use of the humanized rodent models for screening therapeutic efficacy for A1ATD, for example, for screening the efficacy of any treatment selected from the group consisting of liver transplantation, respiratory agents, purified alpha- 1 antitrypsin (A1AT) protein, and gene therapy.

Device (1) for controlling rodents, comprising a housing (2) that includes an access chamber (3) and a bait chamber (4), wherein the bait chamber (4) is accessible only via an access (5) arranged between the chambers (3, 4) and the housing (2) has an opening (9) leading into the access chamber (3), wherein the device (1) comprises an access device (7) and a release means (10), wherein the access (5) can be in a closed state and in an open state, and wherein the access device (7) is configured to close the access (5) with a closing means (8) in the closed state and to release it in the open state, wherein the access device (7) comprises a spring element (12) operatively connected with the closing means (8) by which the closing means (8) can be moved into the open state, wherein the access device (7) is configured toto hold the locking means (8) in its closed position against the action of the spring element (12), and wherein the release means (10) is operatively connected to the access device (7) or the locking means (8) and is designed such that, when the release means (10) is actuated by a rodent present in the access chamber (3), the locking means (8) is moved from the closed state to the open state.

Disclosed is a genetically modified rodent an immunoglobulin light chain locus of which is engineered such that a single rearranged human immunoglobulin light chain gene V / J gene is contained upstream of a constant region of the mouse Kappa light chain locus, and thus a mouse variable region sequence cannot bind to the endogenous constant region to form a complete mouse light chain antibody. The rodent can reproduce normally and produce an antibody containing a human light chain. Also provided are a preparation method for the genetically modified rodent and the use thereof.

A rodent trap comprising an activation mechanism designed to be triggered by a rodent, a disposal mechanism designed to kill the rodent upon activation, a trapdoor located adjacent to the disposal mechanism with a closed and an open position, and a storage area located on the other side of the trapdoor with respect to the disposal mechanism. The trap is designed such that when a rodent is killed by the disposal mechanism, its carcass passes through the trapdoor into the storage area.

A sticky area is strategically located on a snap trap which allows for a rodent to get stuck at the right distance from the bait for the rodent's wriggling to trigger the hammer bar to snap down and kill it instantly. The hammer bar has a first arm, a cross bar, a second arm and a pivot arm which define a kill zone on an attached base when the trap is in its unarmed state. A bait pedal is in the kill zone. The pivot arm is disposed in a coil spring, and a hold-down bar biases the spring and hammer bar in the armed position. A sticky area is disposed outside the kill zone and on at least three sides of the kill zone. The sticky area is on the surface of the base or on a sheet below the top surface of the base.

Provided herein are genetically modified rodents (e.g., mice) comprising a humanized PIGR locus in their genome, for example, positioned at an endogenous mouse PIGR locus. Also provided herein are methods of making and / or using such rodents, cells from such rodents, and rodent ES cells comprising a humanized PIGR locus.

The utility model discloses a kind of rodent transport devices, comprising: box body is equipped with partition baffle structure;Partition baffle structure includes multiple baffle;All baffles are blocked in box body as multiple volume equal rodent containing interval;The middle part of each connecting wall body is connected with the baffle of adjacent respectively;Connecting wall body and the two baffle of being connected form containing space;Each food and water storage structure is arranged in a corresponding containing space;All food and water storage structure and all rodent containing interval one-to-one correspondence, and each food and water storage space is provided with opening towards adjacent one rodent containing interval.The utility model sets up multiple independent rodent containing interval in box body by baffle, so that same box body can carry multiple rodents, and avoid mutual pathogen transmission.

The application provides a method for constructing an animal model of paternal chronic stress leading to changes in the fertility of three generations of the paternal line and application thereof. The chronic stress state of the father is constructed by gavage of male rodents with different doses (15, 30 and 60 mg / kg.d) of caffeine for 8 weeks. After administration, the F0 generation of male mice is mated with normal female mice to obtain the F1 generation, and the latter is mated with female mice to obtain the F2 generation. It is found that the fertility of the three generations of the paternal line changes, which is manifested as a significant decrease in the F0 generation, a decrease in the F1 generation, and a return to normal in the F2 generation. Based on the above-mentioned three-generation fertility change model, it is further found that high glucocorticoids of the F0 generation affect the development of the testis of the F1 generation by changing the methylation of sperm imprinting genes, and the fertility of the three generations is related to the glucocorticoid level of the current generation. The three-generation fertility change model constructed by the application has the characteristics of precision and effectiveness, high success rate, simple operation and strong repeatability, and provides an experimental basis for exploring the mechanism of related diseases and clinical early warning targets.