47 results about "Order Rodentia" patented technology

Transgenic rodents and rodent cells that express components of the human immune system, and their uses in generating human T cell receptors (TCRs). A genetically modified rodent comprising a TCR alpha gene locus comprising unrearranged human TCR alpha variable gene segments and a human TCR alpha constant region, and a TCR beta gene locus comprising unrearranged human TCR beta variable gene segments and a human TCR beta constant region. Use of hTCR transgenic rodents to generate antigen-specific CD8+ T cell responses for the discovery of fully human TCR sequences with therapeutic potential.

Disclosed is a genetically modified rodent, in which an immunoglobulin light chain locus is modified to insert a human immunoglobulin light chain gene segment. The rodent is capable of normal reproduction and of producing antibodies containing human light chains. Further provided are a method for preparing the genetically modified rodent and the use.

The present invention discloses a genetically modified rodent whose immunoglobulin light chain locus is modified so as to comprise a single rearranged human immunoglobulin light chain gene V / J gene upstream of a mouse Kappa light chain locus constant region, a mouse variable region sequence cannot bind to an endogenous constant region to form a complete mouse light chain antibody, the rodents are capable of normally reproducing and producing human light chain-containing antibodies. The invention also provides a method of making the genetically modified rodent and a use of the rodent.

Disclosed herein is a genetically modified rodent, the genetically modified rodent comprising a humanized Clec9a gene in its genome. The invention also discloses an isolated rodent tissue or cell. The isolated rodent tissue or cell comprises a rodent embryonic stem cell and a rodent embryo; a method of making the genetically modified rodent; and methods of using the genetically modified rodents.

To provide a humanized rodent that expresses a heavy chain containing a VL domain. [Solution] A non-human animal, tissue, cell, and genetic material is provided which includes a modification of an endogenous non-human heavy chain immunoglobulin sequence and contains functional ADAM6 activity in a rodent (e.g., mouse), wherein the non-human animal rearranges the human immunoglobulin light chain gene segment in relation to the heavy chain constant domain and expresses an immunoglobulin-like molecule which contains a human immunoglobulin light chain variable domain fused to the heavy chain constant domain and is a cognitive of a human immunoglobulin light chain variable domain fused to the light chain constant domain.

A rodent control apparatus comprising an elongated tube sized to receive a rodent (e.g., rat, mouse, etc.) at a front portion, electrocute the rodent in a middle portion, and propel the rodent's body toward a rodent disposal bag attached to a rear portion. The apparatus is configured to kill and store the remains of many rodents and, as such, finds great utility within the context of reducing a local rodent population.

The invention discloses a pneumatic biological impact machine for plateau small rodents, and relates to the technical field of medical research instruments.The pneumatic biological impact machine comprises a base, a rodent binding mechanism, an impact position rotation adjusting mechanism, an adjustable pneumatic impact mechanism and a biological impact component, a support is installed on the base, and the rodent binding mechanism comprises a circular track; a height adjusting assembly is installed on the rear side of the support and fixedly connected with the front side of the circular track through two supporting rod frames, the pneumatic biological impacting machine for the plateau small rodent stably restrains and fixes the four limbs of the small rodent, meanwhile, the abdomen of the small rodent is fully exposed, and the small rodent is prevented from being damaged. When a small rodent is hit to cause trauma, the small rodent can be always kept in a positive position, internal organs of the small rodent are located at normal positions, the small rodent is hit by the biological hit component, and the obtained small rodent model is good in consistency.

Device (1) for providing a rodenticide bait in a sewer, comprising a holding device (17) for receiving a bait, wherein the bait is freely accessible to rodents in a first position of the device (1), a protective device (7) designed to at least partially enclose the bait, a release mechanism actuated by a rising water level, wherein the protective device (7) is held in an open position in the first position by a retaining element (15), and wherein the release mechanism comprises a float (6) which releases the retaining element (15) when the water level rises, so that the protective device (7) is automatically moved into a closed position in which the bait is shielded from the surrounding water.

The application discloses a rodent mouth opener and a use method thereof, and the mouth opener comprises a sleeve, a sleeve rod, a locking nut, a U-shaped spring, a tooth buckle and a jaw pad. The sleeve, the sleeve rod and the locking nut constitute an oval mouth opener of the rodent mouth opener, the sleeve and the sleeve rod are connected into a whole through the locking nut, and the sleeve rod is convenient to adjust the mouth opener through expansion and contraction in the sleeve. The tooth buckle is connected to the middle part of the sleeve, the tooth buckle is matched with upper and lower front teeth of the rodent, and the tooth buckle is used for sleeving the front teeth of the rodent. The tooth buckle is provided with the jaw pad, the jaw pad prevents the mouth of the rodent from being hurt by being pressed, the middle part of the sleeve rod is connected with the U-shaped spring, the U-shaped spring provides elastic force to open the corners of the mouth of the rodent, and the U-shaped spring can assist in adjusting the opening degree. The application adopts a symmetrical structure design, is fixed firmly, avoids multiple adjustment of fixation and opening degrees of experimental animals caused by loosening or left-right shaking, and can adjust multiple structures to match rodent animals with different opening degrees for experiments.

To provide an oral cavity insertion tool which enables medical equipment, such as a sonde, to be readily inserted into an oral cavity of a rodentia animal in a procedure, such as an oral administration of an administration substance into the rodentia animal, and can prevent the medical equipment from being damaged.SOLUTION: A cylindrical oral cavity insertion tool 10 is to be inserted from a mouth 41 of a rodentia animal 40, and has a lumen 10A extending in a longitudinal axis direction, a first end 11 in a distal side in the longitudinal axis direction, and a second end 12 in a proximal side. The first end 11 and the second end 12 each has an opening communicating with the lumen 10A. In a side of the second end 12 with respect to a middle point 13 in the longitudinal axis direction, the oral cavity insertion tool 10 has an enlarged diameter part 15 in which the diameter of the lumen 10A is enlarged from a side of the first end 11 to a side of the second end 12.SELECTED DRAWING: Figure 3

The present invention discloses a pneumatic biological impact machine for small plateau rodents, which relates to the technical field of medical research instruments. It includes a base, a rodent restraint mechanism, an impact position rotation adjustment mechanism, an adjustable pneumatic impact mechanism and a biological impact component. A bracket is installed on the base. The rodent restraint mechanism includes a circular track. A height adjustment assembly is installed at the rear side of the bracket. The height adjustment assembly is fixedly connected to the front side of the circular track through two support rod frames. This pneumatic biological impact machine for small plateau rodents can stably restrain and fix the limbs of small rodents, and at the same time, the abdomen of small rodents is fully exposed. When causing trauma to small rodents by impact, it can keep small rodents in a forward position all the time, making the internal organs of small rodents in a normal position. The biological impact component impacts small rodents, and the obtained small rodent models have good consistency.

To provide transgenic mammals expressing bovine-based immunoglobulins, including transgenic rodents expressing bovine-based immunoglobulins for the development of bovine therapeutic antibodies.SOLUTION: A transgenic rodent or rodent cell is provided comprising an engineered partially bovine immunoglobulin light chain locus comprising bovine immunoglobulin λ light chain variable region gene segments, wherein the engineered immunoglobulin locus is capable of expressing immunoglobulins comprising bovine variable domains, and wherein the transgenic rodent produces or is likely to produce more immunoglobulins comprising λ light chains than immunoglobulins comprising κ light chains.SELECTED DRAWING: Figure 13

The present invention provides methods and apparatuses that allow rodents to be humanely and safely repelled from places where humans do not want such rodents, using specific apparatuses and chemicals such as pentyl acetate, y-terpinene, and p-cymene.

The utility model belongs to the technical field of rodent fixers, and particularly relates to a rodent cerebral ischemia modeling fixator which comprises a fixing table, and an operating table is arranged at the top end of the fixing table. A rotating shaft is fixed at the lower end of the console; the rotating shaft extends to the inner side of the fixed table and is rotationally connected with the fixed table; an inserting assembly is arranged at the position, corresponding to the rotating shaft, of the inner side of the fixing table; fixing assemblies are arranged at the top end of the operation table. By means of the structural design of the fixing assembly, when a rodent needs to be fixed, the rodent can be placed between two clamping plates, then the clamping plates are moved through the driving assembly so that the rodent can be fixed, and then the neck and the head of the rodent are fixed separately; therefore, the stability of the animal in the experiment process is improved, meanwhile, the device can adapt to rodents of different body types, the success rate of the experiment is improved, and injury caused by struggling of the animal is avoided.

Provided herein are methods and compositions related to in vivo testing of therapeutic agents comprising a human Fc in genetically modified rodents (e.g., testing the pharmacokinetic and / or pharmacodynamic properties of such therapeutic agents in genetically modified rodents). In some embodiments, the genetically modified rodents express antibodies comprising a human Fc (e.g., human IgG1 Fc, human IgG4 Fc). In some embodiments, the rodents express fully human antibodies (i.e., antibodies having human heavy chains and human light (γ or κ) chains). In certain embodiments, the genetically modified rodent comprises one or more Fc receptors with human extracellular domains (e.g., neonatal Fc receptor (FcRn), β-2-microglobulin polypeptide (β2M), Fcε receptor 1α (FcεR1α), Fcγ receptor 1α (FcγR1a), Fcγ receptor 2a (FcγR2a), Fcγ receptor 2b (FcγR2b), Fcγ receptor 3a (FcγR3a), Fcγ receptor 3b (FcγR3b), Fcγ receptor 2c (FcγR2c)). The transmembrane and cytoplasmic domains of the receptor can be human or non-human (e.g., rodent).

A live catch rodent trap comprises a housing, an entry door, a release or exit door, and a latch assembly. The housing defines a first or entry opening, and a second or release opening. The entry door selectively covers the first opening, enabling a rodent to enter an interior of the trap and to be captured therewithin. The release door is pivotally attached to the housing. The release door is, in response to actuation by a user, movable between a closed position covering the second opening, and a release position at least partially uncovering the second opening and permitting a rodent to exit the interior of the trap. The latch assembly selectively secures the release door in the closed position, and includes an actuator adapted to be engaged or biased by a user for releasing the latch assembly from a latched state.

A live catch rodent trap comprises a housing, an entry door, a release or exit door, and a latch assembly. The housing defines a first or entry opening, and a second or release opening. The entry door selectively covers the first opening, enabling a rodent to enter an interior of the trap and to be captured therewithin. The release door is pivotally attached to the housing. The release door is, in response to actuation by a user, movable between a closed position covering the second opening, and a release position at least partially uncovering the second opening and permitting a rodent to exit the interior of the trap. The latch assembly selectively secures the release door in the closed position, and includes an actuator adapted to be engaged or biased by a user for releasing the latch assembly from a latched state.

A pest trap (1), in particular for controlling rodents, comprising a base body with an interior (3) and an entrance opening (4) leading into the interior (3), wherein a rocker (5) is arranged in the area of ​​the entrance opening (4), which is pivotably mounted about an axis of rotation (8) and has a passage (9) for a rodent and has at least a first rocker side (6) facing the entrance opening (4) with an outer surface (12) that can be walked on by a rodent and a second rocker side (7) facing the interior (3) with an inner surface (11) of the passage (9) that can be walked on by a rodent, wherein the rocker (5) is pivotable between a first position and a second position, and wherein the rocker (5) is operatively connected to a closing element of the entrance opening (4) such that when the walkable inner surface (11) is entered, the rocker (5) is pivoted into the first position.wherein the locking element closes the entrance opening (4), and when the outer surface (12) of the first rocker side (6) is entered, the rocker (5) pivots from the first position to the second position, in which the entrance opening (4) is released by the locking element.

An orally ingestible contraceptive low dose gossypol composition for rodents such as mice, rats and members of the order Rodentia is provided. The contraceptive composition comprises 0.0005 to 0.0045 wt. % of gossypol and a carrier. The carrier includes a bulk feed component. The bait or soft bait may be encased in a casing such as a collagen casing. Also provided is a method for contraception of rodents comprising administering the low dose-gossypol composition by making the contraceptive available for feeding the target animal.

Device for controlling rodent pests, comprising a killing agent (6, 7) and a carrier with a carrier surface that rodent pests can walk on, wherein the killing agent (6, 7) is attached to the carrier and defines an effective area extending along a section of the carrier surface frequented by rodents, the killing agent (6, 7) is oriented relative to the carrier in such a way that a rodent killed in the effective area falls away from the carrier surface by gravity and the effective area remains open for a subsequent rodent, and the killing device (6, 7) has at least one triggering device projecting into the effective area, which can be actuated by a rodent crossing the effective area to trigger a killing process, wherein the killing device (6, 7) is switchable between an activated state and a deactivated state.

The invention provides an I-type primary hyperoxaluria animal model as well as a preparation method and application thereof. Specifically, the invention provides an application of a combination of experimental materials, and the combination is used for preparing a rodent model of type I primary hyperoxaluria (PH1). A mouse model in which 3rd to 8th exons of the Agxt gene are knocked out and a specific dose of glyoxylic acid are used, so that the human disease phenotype of the type I primary hyperoxaluria can be more accurately simulated, the modeling time is greatly shortened, the research cost is reduced, and the method is suitable for popularization and application. The pathogenesis of the PH1 can be better clarified, and the searching of a PH1 immunotherapy target spot and method and the screening of a medicine for treating the PH1 are promoted.

To provide an oral cavity insertion tool which enables medical equipment, such as a sonde, to be readily inserted into an oral cavity of a rodentia animal in a procedure of an oral administration of an administration substance into the rodentia animal, and can prevent the medical equipment, such as a sonde, from being damaged.SOLUTION: A cylindrical oral cavity insertion tool 10 is to be inserted from a mouth 21 of a rodentia animal 20, and has a lumen 10A extending in a longitudinal axis direction, a bend part 15, a first end 11 in a distal side in the longitudinal axis direction, and a second end 12 in a proximal side. The first end 11 and the second end 12 each has an opening communicating with the lumen 10A. The shape of the opening 12A of the second end 12 has a long axis 12L and a short axis 12S. The short axis 12S extends in a range of -30° to +30° with respect to a plane A including a central axis of the bend part 15.SELECTED DRAWING: Figure 4

Transgenic rodents and rodent cells expressing components of the human immune system, and their use in the generation of human T cell receptors (TCRs). Genetically modified rodents containing a TCRα gene locus with an unreorganized human TCRα variable gene segment and human TCRα constant region, and a TCRβ gene locus with an unreorganized human TCRβ variable gene segment and human TCRβ constant region. Antigen-specific CD8 for finding fully human TCR sequences with therapeutic potential. + Use of hTCR transgenic rodents that generate T cell responses.

The invention relates to the technical field of specimen manufacturing, in particular to a safe manufacturing process of a small rodent high-fidelity ecological specimen. Comprising the following steps: taking a mouse corpse, and fixing the mouse corpse on a mouse dissecting disc; dissecting the mouse, taking out organs, cutting off mouse tongues, and releasing muscles; putting the anti-corrosion powder into released muscles of the abdominal cavity, the chest, the oral cavity and the neck of the mouse, and finally filling the mouse with the anti-corrosion powder; tearing the cotton ball into a sheet shape, covering the space between the mouse chest, abdominal cavity, neck preservative powder and skin, sewing, then taking down and inserting on a foam plate, adjusting the shape, and arranging hair; and putting the modeled mouse book into a paper box, pouring anti-corrosion powder, sealing the box, air-drying, taking out the mouse book, wiping off the anti-corrosion powder, installing an artificial eye, displaying and pasting an information label, thereby finishing the manufacturing. The ecological specimen prepared through the method is vivid in form, the operation method is simple, and no chemical hazard or risk exists.

A rodent trap adapted to insert through a wall surface, in some embodiments into an interior, inaccessible void, the rodent trap comprising an elongated tubular component having an open distal end and an open proximal end, the open proximal end connected to a vacuum and flexible arm, the rodent trap operable to suck a rodent entering the elongated tubular component into the vacuum.

A live catch rodent trap comprises a housing, an entry door, a release or exit door, and a latch assembly. The housing defines a first or entry opening, and a second or release opening. The entry door selectively covers the first opening, enabling a rodent to enter an interior of the trap and to be captured therewithin. The release door is pivotally attached to the housing. The release door is, in response to actuation by a user, movable between a closed position covering the second opening, and a release position at least partially uncovering the second opening and permitting a rodent to exit the interior of the trap. The latch assembly selectively secures the release door in the closed position, and includes an actuator adapted to be engaged or biased by a user for releasing the latch assembly from a latched state.

To provide rodent models have been developed to generate antibodies suitable for use in other species, such as companion animals.SOLUTION: Provided are rodents and cells that are engineered to contain the exogenous DNA of companion animals, their use in medicine and the study of disease, methods for production of rodents and cells, and antibodies and antibody chains produced by such animals and derivatives thereof.SELECTED DRAWING: None

A rodent control apparatus comprising an elongated tube sized to receive a rodent (e.g., rat, mouse, etc.) at a front portion, electrocute the rodent in a middle portion, and propel the rodent's body toward a rodent disposal bag attached to a rear portion. The apparatus is configured to kill and store the remains of many rodents and, as such, finds great utility within the context of reducing a local rodent population.

The utility model relates to the technical field of rodent nose tissue pathological specimen material taking, specifically discloses rodent nasal mucosa tissue material taking device, the one side of fixed plate is provided with first fixed clamping groove and second fixed clamping groove respectively, is provided with head container on the fixed plate, is provided with first clamping groove insertion port, second clamping groove insertion port and cutting knife clamping groove on head container respectively, and the one side of head container is provided with scale, the rodent nasal mucosa tissue material taking device whole simple structure, and the installation and use are convenient, and the material taking work of rodent nasal mucosa tissue of staff is convenient, since setting up the scale for measuring distance on the bottom plate, a plurality of graduation grooves are opened on the scale, the position of rodent head tissue is measured through the scale, is convenient for its accurate cutting, thereby help to improve the accuracy of rodent nasal mucosa tissue material taking.