The invention discloses a multi-point-support five-cylinder plunger pump. The multi-point-support five-cylinder plunger pump comprises a power end assembly, a hydraulic end assembly and a speed reduction box assembly, wherein the power end assembly comprises a crankshaft box body, a crosshead box body and a space rack, and the crankshaft box body, the crosshead box body and the space rack are connected in sequence; the hydraulic end assembly is fixed on the space rack, the speed reduction box assembly is fixed to the crankshaft box body, the bottom of the crankshaft box body is provided with acrankshaft supporting body, and the crankshaft supporting body is used for supporting the crankshaft supporting box body; the bottom of the crosshead box body is provided with a crosshead supportingbody, the crosshead supporting body is used for supporting the crosshead box body, the bottom of the space rack is provided with a hydraulic supporting body, and the hydraulic supporting body is usedfor supporting the hydraulic end assembly. The multi-point-support five-cylinder plunger pump has the advantages that through the multi-point-support design on the crankshaft box body, the crosshead box body and the hydraulic end assembly, the support strength of the plunger pump can be improved, vibration is reduced, high-load work is better guaranteed, and the plunger pump runs more stably.