Microflow control chip integrated unit in integrated constant temperature system in high efficiency

A microfluidic chip and constant temperature system technology, applied in the field of chemistry, can solve problems that affect the reproducibility and reliability of experimental results, lack of temperature control devices, and limit the analysis range of electrophoresis chips.

Inactive Publication Date: 2008-02-06
NANJING UNIV
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Problems solved by technology

The lack of a temperature control device, on the one hand, limits the analysis range of the electrophoresis chip, such as: the need for reaction and separation at a specific temperature; on the other hand, the change of temperature will affect the reproducibility and reliability of the experimental results

Method used

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  • Microflow control chip integrated unit in integrated constant temperature system in high efficiency

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Embodiment Construction

[0012] As shown in Figures 1, 2 and 3, the microfluidic chip integrated device (taking electrochemical detection as an example) for making an integrated high-efficiency constant temperature system provided by the present invention includes the following three steps: (1) firstly make a constant temperature system platform and Electrolytic cell (1 two square miniature incubators, 4 liquid inlet and outlet holes of the constant temperature system, 5 nuts for adjusting the height between the two miniature incubators, 7 electrolytic cell, 8 base, 9 electrophoresis high voltage electrode hole (separate positive end , sample injection positive end and sample injection negative end), 11 electrophoresis high-voltage electrode holes (separate negative end), 12 pairs of electrode holes, 13 reference electrode holes); (2) fix the micro three-dimensional regulator on the other side of the base ( 3 miniature three-dimensional regulators, 6 working electrodes); (3) placing chips (2 microfluid...

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Abstract

This is a kind of miniflow control chip integral device of highly efficient constant temperature system. It includes a temperature thermostat and a micro 3D controller. The 3D controller is fixed on one side of the bed flatform, and the temperature thermostat is made up of two micro metal incubators, one on the top and the other on the bottom. In the incubators there are circulate conduits for the temperature-controlling working substance, and between the incubators the miniflow control chips are set on the flatform. Also there are the sustainer and the spiral controlling nuts between the incubators to make the height between two incubators almost the same as the thickness of the chip. This invention is miniflow control chip integral device of the integrated temperature thermostat, and using it can make the experiment run in the temperature set before and cancel the perturbance of the temperature in and outside the system. As a resut, we can greatly improve the replaying ability of the experiment and widen the use and researching area of the electrophoretic chip.

Description

technical field [0001] The present invention is a microfluidic chip integrated device integrating a high-efficiency constant temperature system. Specifically, the constant temperature device is directly integrated into the capillary electrophoresis chip system to take advantage of the high-efficiency constant temperature of the thermostat. The integrated system is suitable for various chips. Detection technology (such as optical detection, electrochemical detection and mass spectrometry detection, etc.) belongs to the field of chemistry. Background technique [0002] The micro-total analysis system is one of the research frontier hotspots in analytical science. The micro-total analysis system integrates the entire analysis process in the laboratory, such as sample processing, sample filtration, sample separation, and sample detection, on a small chip, which can realize the automation and miniaturization of the entire analysis process. [0003] An important hotspot in the fi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N31/00B01L7/00
Inventor 夏兴华刘爱林何凤云徐静娟
Owner NANJING UNIV
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