Galantamin hydrobromide production method

Abstract

The invention discloses a galantamin hydrobromide producing method for treating senile dementia, which comprises the following steps: adopting the method of enzyme reaction, continuous kinesis flow upstream extracting and column chromatography to extract galantamin with purity of 99% from Amaryllidaceae plant; Using galantamin with purity of 99 percent as raw material; obtaining galantamin hydrobromide with purity of 98.5. percent. The invention discloses an extracting galantamin of purity at 99% process flow and technological condition from Amaryllidaceae plant, which adapts for industrialization production.

Description

Technical field:

[0001] The invention relates to a production method of a medicine, in particular to a production method of galanthamine hydrobromide, a drug with good curative effect for treating senile dementia. Background technique:

[0002] Galanthamine hydrobromide English name: Galanthamine Hydrobromide, scientific name: 11-methyl-3-methoxy-4a, 5, 9, 10, 11, 12-hexahydro-benzofuran (3a, 3, 3 -ef)-(2) azepine-6-alcohol hydrobromide; , the molecular formula is C 17 h 21 o 3 N·HBr, its characteristic is white or almost white crystalline powder, odorless, bitter taste, this product is soluble in water, slightly soluble in ethanol, insoluble in acetone, chloroform, ether or benzene. Galantamine hydrobromide is a second-generation acetylcholinesterase inhibitor, and it is a reversible acetylcholinesterase inhibitor, which can resist acetylcholinesterase and regulate pharyngeal acid receptors. This product can improve the conduction between nerves and muscles, and is used...

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