Catalyzing synthesis of polylactide and polyserine morphodilone from carboxylic acid creatinine guanidine
A technology of serine morpholine dione and polylactide, which is applied in the field of catalytic synthesis of medical biodegradable polyesters, can solve problems such as cytotoxicity and unsafe hidden dangers, and achieve no environmental pollutants, high yield, and process simple effect
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Embodiment 1
[0032] Example 1 Creatinine acetate catalyzed synthesis of poly-L-lactide
[0033] Weigh 1.728g (0.012mol) of L-lactide and 0.0069g (0.00004mol) of guanidine acetate creatinine respectively and put them in the reactor. Reacted in the bath for 96 hours. After the reaction, the polymer was dissolved with a small amount of acetone, slowly dropped into distilled water to precipitate the polymer, filtered to remove the distilled water, and the obtained solid was vacuum-dried for 24 hours. Yield: 94.0%, Mn=4.0×10 4 , PDI = 1.08.
Embodiment 2
[0034]Example 2 Creatinine acetate catalyzed synthesis of poly-L-lactide
[0035] Weigh 1.728g (0.012mol) of L-lactide and 0.0069g (0.00004mol) of guanidine acetate creatinine respectively and put them in the reactor. Reacted in the bath for 96 hours. After the reaction, the polymer was dissolved with a small amount of acetone, slowly dropped into distilled water to precipitate the polymer, filtered to remove the distilled water, and the obtained solid was vacuum-dried for 24 hours. Yield: 96.1%, Mn=4.2×10 4 , PDI = 1.10.
Embodiment 3
[0036] Example 3 Creatinine acetate catalyzed synthesis of poly-L-lactide
[0037] Weigh 1.728g (0.012mol) of L-lactide and 0.0069g (0.00004mol) of guanidine acetate creatinine respectively and put them in the reactor. Reacted in the bath for 96 hours. After the reaction, the polymer was dissolved with a small amount of acetone, slowly dropped into distilled water to precipitate the polymer, filtered to remove the distilled water, and the obtained solid was vacuum-dried for 24 hours. Yield: 92.8%, Mn=4.0×10 4 , PDI = 1.19.
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