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Compound soft lutein capsule and its preparing process

A compound soft capsule and lutein technology, which is applied in the direction of capsule delivery, drug combination, active ingredients of hydroxyl compounds, etc., can solve problems such as high price, affecting product quality, and solvent residue, so as to improve vision and prevent atherosclerosis , the effect of reducing the risk

Active Publication Date: 2008-07-09
JIANGSU ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the production process of the solvent method, a large amount of expensive organic solvents such as n-hexane are consumed, and there are solvent residues, which affect the quality of the product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Preparation of lutein: 800 g of marigold flower granules, crushed to a particle size of 20 mesh, supercritical CO 2 The extraction conditions are: extraction pressure is 30MPa, extraction temperature is 45°C, CO 2 The flow rate is 60L / h, and the amount of entrainer ethanol is 20% of the raw material; supercritical CO 2 The separation conditions are as follows: the pressure of the primary separation tank is 8 MPa, and the temperature is 45°C; the pressure of the secondary separation tank is 5 MPa, and the temperature is 45°C. After dynamic operation for 4 hours, the extract was obtained from the primary separation kettle, and after standing, filtering and concentrating, 76 g of lutein oleoresin was obtained, with a lutein content of 6.0%;

[0021] (2) Preparation of α-linolenic acid: take perilla seed and refine it after pressing (commonly used refining method in production) to obtain α-linolenic acid, wherein the content of α-linolenic acid in perilla seed oil is 4...

Embodiment 2

[0025] 800g of marigold flower granules, and 20g of perilla seeds rich in α-linolenic acid are added to it at the same time, the crushed particle size is 20 mesh, supercritical CO 2 The extraction conditions are: extraction pressure is 30MPa, extraction temperature is 45°C, CO 2 The flow rate is 50L / h, and the amount of entrainer is 20% of the raw material; supercritical CO 2 The separation conditions are as follows: the pressure of the primary separation tank is 8 MPa, and the temperature is 45°C; the pressure of the secondary separation tank is 6 MPa, and the temperature is 45°C. The dynamic operation is 4 hours, the extract is obtained from the primary separation tank, and after standing, filtering and concentrating, 78g of perilla seed oil and lutein oleoresin mixture (including 6g of perilla seed oil) is obtained, and the lutein content is 5.6%; Same as implementation example 1. Each compound soft capsule made is 500 mg, and the formula is: 6 mg of lutein, 200 mg of α-l...

Embodiment 3

[0027] Marigold flower granules 1000g, crushed particle size is 20 mesh, supercritical CO 2 The extraction conditions are: extraction pressure is 30MPa, extraction temperature is 45°C, CO 2 The flow rate is 60L / h, and the amount of entrainer is 20% of the raw material; supercritical CO 2 The separation conditions are as follows: the pressure of the primary separation tank is 8 MPa, and the temperature is 45°C; the pressure of the secondary separation tank is 5 MPa, and the temperature is 45°C. After dynamic operation for 5 hours, the extract was obtained from the first-stage separation tank, and after standing, filtering and concentrating, 92 g of lutein oleoresin was obtained, and the lutein content was 6.3%; the others were the same as in Example 1. Each compound soft capsule made is 750 mg, and the formula is: 9 mg of lutein, 300 mg of α-linolenic acid, 1 mg of vitamin A, and 2 mg of vitamin E.

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Abstract

The present invention discloses one kind of composite soft lutein capsule and its preparation process. The content in each capsule includes lutein1-10 mg, alpha-linolenic acid 100-300 mg, vitamin A 0-5 mg and vitamin E 0-7.5 mg; and the capsule covering consists of gelatin, glycerin, water, and opacifier or edible color. The lutein is prepared through supercritical CO2 extraction process, and has no pollutant and organic solvent residue. The composite soft lutein capsule product has stable quality and high bioavailability, and has certain preventing and treating effect on senile macular degeneration, cataract and cardiac and cerebral vascular diseases.

Description

1. Technical field [0001] The invention relates to a lutein composite soft capsule and a preparation process thereof, which is specially used for the preparation of lutein capsules. 2. Technical background [0002] In recent years, scientific research has reported that lutein is the main component of macular pigment in the human eye. On the one hand, it can filter out the blue light that has the strongest effect on macular damage, and on the other hand, it can quench and capture the active oxygen free radicals induced by high-energy blue light, thereby reducing the damage to optic nerve cells, and playing the role of antioxidant and vision protection effect. Studies have shown that regular consumption of foods rich in carotenoids, especially lutein, and increasing the intake of lutein in the diet can increase the level of lutein in the blood and reduce age-related macular degeneration (Age-related Macular Degeneration, referred to as AMD, a disease in which levels of the m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/07A61K9/48A61P27/02
Inventor 刘春泉李大婧
Owner JIANGSU ACAD OF AGRI SCI
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