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Production of silicon rubber surface apatite coating by biomimetic method

A silicone rubber and apatite technology, applied in medical science, prosthesis, surgery, etc., can solve problems such as formation difficulties

Inactive Publication Date: 2008-08-20
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To form an apatite coating on the surface of a polymer using a biomimetic method, it is usually necessary to form groups that can induce crystal nucleation on the surface, such as -OH, -COOH, -SiOH, etc. to induce the formation of apatite crystal nuclei. The surface of silicone rubber is inert and highly hydrophobic -CH 3 , it is difficult to form new groups on the surface

Method used

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  • Production of silicon rubber surface apatite coating by biomimetic method
  • Production of silicon rubber surface apatite coating by biomimetic method
  • Production of silicon rubber surface apatite coating by biomimetic method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 prepares apatite coating on the surface of silicone rubber

[0018] The preparation method steps are:

[0019] (1) Preparation and pretreatment of silicone rubber substrate

[0020] Cut a silicone rubber sheet with a thickness of 1.0mm into a square of 10mm×10mm, roughen the surface with 400# fine sandpaper, then put it into an ethanol solution for ultrasonic cleaning, and dry it in an oven at 40°C for 24 hour spare;

[0021] (2) Dip the silicon rubber sheet cleaned in step (1) into CaCl 2 Take it out after 10 seconds in the ethanol solution with a concentration of 0.1 mol / L, dry it in the air and slowly immerse it in K 2 HPO 4 ·3H 2 O concentration is taken out after 10 seconds in the aqueous solution of 0.1 mol / L;

[0022] (3) Impregnation of silicone rubber substrates in calcium phosphorus saturated solution

[0023] Prepare 1000ml calcium phosphorus saturated solution (Calcium Phosphate supersaturated solution, CP solution), dissolve 8.035g NaCl,...

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Abstract

A bionic method for preparing the coated apatite layer on the surface of silica rubber includes such steps as grinding the surface of silicone rubber, washing, sequentially immersing it in the alcohol solution of CaCl2 and the aqueous solution of K2HPO4.3H2O to form an amorphous calcium phosphate layer on the surface of silicone rubber, and immersing it in the Ca-P saturated solution for a certain time. It can be used as the hypodermic-implant with excellent biocompatibility.

Description

Technical field: [0001] The invention relates to a method for preparing an apatite coating on the surface of silicone rubber. Background technique: [0002] Medical silicone rubber is a commonly used material for implantation in the body. It has good physical and chemical stability and physiological inertia, can be implanted in the body for a long time, and is easy to process and shape; it also has aging resistance under complex environmental conditions. However, because the molecular polarity of silicone rubber is very low, it shows extremely strong hydrophobicity, which leads to poor affinity with the body after implantation. The epidermis grows down the material, trapping bacteria and causing inflammation in the gaps between the implant and the tissue. Apatite ceramics is a very biocompatible material. Subcutaneous implants made of hydroxyapatite can be implanted subcutaneously for a long time without causing adverse reactions. However, apatite ceramics are brittle and c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L31/12
Inventor 王欣宇韦明李世普王友法安江峰焦国豪杨艾玲张炜
Owner WUHAN UNIV OF TECH