Heat-sensitive gel containing matrine alkaloid and its preparing method

Abstract

The present invention relates to a heat-sensitive gel preparation containing matrine alkaloid and its preparation method. Said preparation is composed of matrine alkaloid, hydroxypropyl methylcellulose, poloxamer 407, phosphate buffer solution whose pH value is 5.0-7.0, glycerin and preservative. It is flowable fluid at normal temperature, and when the temperature is 28-33 deg.C, it can produce phase change, and can be formed into gel, so that it can be conveniently applied to vagina, mucous membrane of external genitalia, skin and eye.

Description

technical field

[0001] The present invention relates to a heat-sensitive gel containing matrine alkaloids, in particular to a medicinal composition containing matrine alkaloids as an active ingredient and poloxamer 407. The composition has Heat-sensitive gel, can be applied to human body parts such as vagina, eyes, external genital mucous membrane and common skin. The invention also relates to a preparation method of the thermosensitive gel preparation. Background technique

[0002] Matrine alkaloids are a class of alkaloids with the chemical structure characteristics of matrine-15-one. They are mainly natural products isolated and extracted from plants Sophora flavescens and Sophora flavescens, including the total alkaloid parts (referred to as flavescens for short). total alkaloids) and monomeric compounds purified from matrine total alkaloids, such as matrine, oxymatrine, sophoridine, aloperine, sophocarpine, sophoramine, sophoryl, oxidized sophocarp alkali. Most matri...

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