An even low-shearing self-absorbing emulsion droplet preparation device

Abstract

The invention relates to a device for preparing even self-feeding milk drop. It is characterized in that the bottom of revolution axis connected with motor is jointed with cylinder; the liquid separator can comprises a revolving drum equipped with a feed outlet on side face and with its open upward or downward and cylinder connected to bottom of revolving drum. The invention is characterized in that it can generate negative pressure under slow rotating speed, and disperse light or heavy phase into another phase, the shearing force liquid got is even and milk drop size is relatively homogeneous. The invention is characterized by low investment, easy to operate, small energy consumption, small shearing force to solution and easy for industrialization.

Description

technical field [0001] The invention relates to an emulsion preparation device in the fields of medicine, biochemical industry, food and the like, in particular to a uniform low-shear self-priming emulsion drop preparation device. technical background [0002] In the pharmaceutical, food and other industries, the inhomogeneity of emulsion droplet size is a prominent problem in the process of preparing emulsion. For example, when preparing emulsion droplets with a particle size of 10-200 μm, commonly used emulsification equipment includes mechanical stirring devices, emulsification homogenizers, etc., all of which have excessive local shear force, which leads to the generation of small particle size droplets (particle size less than 10μm). On the one hand, because biological systems are sensitive to acid-base, organic solvents, and mechanical shearing forces, local excessive shearing forces can easily cause inactivation and decomposition of biological substances such as prot...

AI Technical Summary

Problems solved by technology

For example, when preparing emulsion droplets with a particle size of 10-200 μm, commonly used emulsification equipment includes mechanical stirring devices, emulsification homogenizers, etc., all of which have excessive local shear force, which leads to the generation of small particle size droplets (particle size less than 10μm)

On the one hand, because biological systems are sensitive to acid-base, organic solvents, and mechanical shearing forces, local excessive shearing forces can easily cause inactivation and decomposition of biological substances such as proteins; on the other hand, milk droplets Inhomogeneous diameter will inevitably lead to instability of the emulsion system, prone to coagulation and rupture between emulsion droplets, poor experimental repeatability

Moreover, since it is an emulsion system, it is very difficult to further improve the particle size uniformity of the emulsion by sieving

[0003] Chinese Patent Publication No. CN1318422A, published on October 24, 2001, the name of the invention is "self-priming multi-channel phase dispersion extraction device", the application scheme discloses a self-priming multi-channel phase dispersion device, the device It can better solve the problem of excessive local shear force in conventional emulsion preparation methods

Its shortcomings are: the device is mainly used for extraction, and the uniformity of the particle size of the milk droplets is not high; when the liquid in different channels is thrown out, the torque is different; and the height of the different channels immersed in the liquid surface is different, resulting in the discharge The static pressure of the liquid at the mouth is also different, so the particle size of the prepared emulsion is not uniform

The disadvantage is that the diameter of the liquid disperser is larger than the inner diameter of the hollow shaft with the feed inlet, so the particle size of the emulsion droplets generated by liquids with different flow rates flowing out from different positions of the hollow shaft is quite different.

Moreover, the feed inlet of the device is relatively small, and it takes a long time to prepare the emulsion, which easily causes the inactivation of biological substances; in addition, the device is also difficult to scale up industrially.

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