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Extraction method for daphnoretin

A technology of cyretin and an extraction method, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of insufficient yield, waste of resources, low purity and the like, and achieves simple extraction methods and extraction conditions. Gentle, low-cost effect

Active Publication Date: 2009-02-25
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to solve the problems that the existing sipratin extraction technology is poor, the yield is less than 0.004%, and the purity is lower than 90%, resulting in the waste of a lot of resources and the high production cost of sipratin. Extraction method of daphnetin

Method used

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  • Extraction method for daphnoretin
  • Extraction method for daphnoretin
  • Extraction method for daphnoretin

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specific Embodiment approach 1

[0008] Specific embodiment 1: In this embodiment, siruphin is extracted according to the following steps: (1) Grinding the washed Liaogewang into particles with a particle size of less than 10 meshes, and then putting it into a granule with a temperature of 85 to 100°C and a concentration of 50% to 50%. 85% ethanol was extracted 2 to 3 times, and the extraction time was 2 to 4 hours each time, and filtered under the condition that the temperature of the extract was 85 to 90°C; Concentrate to a solid phase under the condition of ℃; (3) The concentrated solid phase is extracted by petroleum ether, chloroform, and ethyl acetate in sequence, and each solvent is extracted 3 to 4 times respectively; (4) Combine the ethyl acetate extracts Carry out drying, then separate the dried extract through silica gel column chromatography twice, and use a volume ratio of 100-80:0-20 chloroform-methanol liquid gradient elution; (5) combine the eluents, and then , and dried under the condition of...

specific Embodiment approach 2

[0013] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the Liaogewang granules pulverized in step (1) is put into temperature and is 90~95 ℃, concentration is the ethanol extraction of 60%~80% 3 times , each extraction time is 3h. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0014] Specific embodiment three: the difference between this embodiment and specific embodiment one is: the Liaogewang granule pulverized in step (1) is put into temperature and is 95 ℃, concentration is the ethanol extraction of 65%~70%. Other steps and parameters are the same as those in Embodiment 1.

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Abstract

The invention discloses an extracting method of mezerein and drug with mezerein, which comprises the following steps: using alcohol to extract gewang; condensing; extracting; chromatographing; eluting; recrystallizing; drying; obtaining the product with receiving rate at 0.014%-0.03% and purity at 97.00%-99.99%. The drug with mezerein is made of 45-55% mezerein, 40-50% microcrystal cellulose and 3-7% magnesium stearate.

Description

technical field [0001] The invention relates to a method for extracting medicinal components in decoction pieces of traditional Chinese medicine. Background technique [0002] Malignant tumor (cancer) is a serious disease that endangers people's life and health. At present, most of the anti-tumor preparations in clinical use are chemically synthesized, with high toxic and side effects and relatively expensive prices. Traditional Chinese medicines are drawn from natural animals and plants, and have little toxic and side effects. Among them, the sirupin extracted from the medicinal material Ligewang has the most remarkable effect on treating malignant tumors. [0003] Liao Gewang is a commonly used Chinese herbal medicine, also known as Nanling Weed, which belongs to the genus of Daphneaceae. It was first recorded in "Lingnan Herbal Records". It is cold in nature, bitter in taste, slightly pungent, and poisonous. Function heat-clearing and toxic substances removing, resolving...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/08A61K31/366A61K9/08A61P35/00A61K36/83A61K125/00
Inventor 杜智敏杨振宇郭薇
Owner HARBIN MEDICAL UNIVERSITY
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