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Application of hyaluronate in preparing oral products used for preventing or improving ocular vitreous degeneration disease

A technology of vitreous degeneration and hyaluronic acid, which is applied in sensory diseases, medical preparations containing active ingredients, organic active ingredients, etc. Eye mucosa damage, good biocompatibility

Active Publication Date: 2009-07-08
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the role of the eye barrier, external use such as eye drops cannot reach the vitreous body of the eye to play a role, and it is still necessary to find a new way

Method used

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  • Application of hyaluronate in preparing oral products used for preventing or improving ocular vitreous degeneration disease
  • Application of hyaluronate in preparing oral products used for preventing or improving ocular vitreous degeneration disease

Examples

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Effect test

Embodiment 1

[0020] Embodiment 1: Hyaluronic acid oral capsule for preventing or improving ocular vitreous degenerative diseases: in 100 grams, 20 grams of sodium hyaluronate (molecular weight: 1.2 million) and 80 grams of hydroxypropyl methylcellulose. Fill it into empty capsules by conventional methods.

Embodiment 2

[0021] Embodiment 2: Hyaluronic acid oral tablets for preventing or improving ocular vitreous degenerative diseases: based on 100 grams of oral tablets, wherein sodium hyaluronate (molecular weight is 800,000) 3.5 grams, appropriate amount of starch slurry, appropriate amount of starch, stearin Moderate amount of magnesium acid, appropriate amount of dry starch. Tablets are prepared by granulating and compressing by conventional methods.

Embodiment 3

[0022] Embodiment 3: Hyaluronic acid oral solution for preventing or improving eye vitreous degenerative diseases: based on 100 grams of oral solution, 0.1 gram of sodium hyaluronate (molecular weight: 1,800,000), appropriate amount of preservative, and appropriate amount of water. Prepare oral liquid by conventional method.

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Abstract

The invention relates to the application of hyaluronic acid in the preparation of oral products for preventing or improving ocular vitreous degenerative diseases. The present invention uses hyaluronic acid to prevent or improve ocular vitreous degenerative diseases by oral administration, which has the following advantages: (1) hyaluronic acid can be absorbed orally and reach eye organs, and can reduce the molecular weight and / or quantity of hyaluronic acid in ocular vitreous degenerative diseases Vitreous liquefaction and related lesions caused by the reduction of vitreous, in order to achieve the purpose of preventing or improving ocular vitreous degenerative diseases, its biocompatibility is good, and it has no side effects when taken orally. (2) Hyaluronic acid has a protective effect on the mucous membrane. After oral administration, it can effectively protect the ocular mucous membrane from irritation and damage, so as to avoid ocular mucous membrane damage that may be caused by ocular degenerative diseases.

Description

technical field [0001] The invention relates to the application of hyaluronic acid in the preparation of oral products for preventing or improving ocular vitreous degenerative diseases, and belongs to the technical field of health food and medicine. Background technique [0002] Background technology of hyaluronic acid [0003] Hyaluronic acid (hyaluonic acid, also known as hyaluronic acid), naturally present in the human body, is a polymer straight-chain mucopolysaccharide composed of glucuronic acid and N-acetylglucosamine as disaccharide units. Hyaluronic acid mostly exists and is used in its salt form (such as sodium hyaluronate). Hyaluronic acid has unique viscoelasticity and non-Newtonian fluid properties, and has important pharmacological and physiological functions. Water retention is one of the most important physiological functions of hyaluronic acid. The long molecular chains of hyaluronic acid interweave into a network and form hydrogen bonds with or water. The...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/723A61P27/02
Inventor 凌沛学侯丽君荣晓花
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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