Wrapped tablets dichlororeytadin and its preparing method

A technology of desloratadine and coated tablets, which is applied in the field of pharmaceutical compositions and preparations thereof, can solve the problems of desloratadine being unstable when exposed to oxygen and moisture, and degraded by oxygen, so as to solve the problems of moisture degradation, Improve stability, reduce the effect of handlers
CN100518722CInactive Publication Date: 2009-07-29SHENZHEN SALUBRIS PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENZHEN SALUBRIS PHARMA CO LTD
Publication Date
2009-07-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

A coated Desloratadine tablet features that it contains beta-cyclodextrin and leucine for preventing its degradation in oxygen and moisture, resulting in high stability. Its preparing process is also disclosed.
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Description

technical field

[0001] The invention relates to a medicine composition and a preparation method thereof, in particular to a desloratadine tablet and a preparation method thereof. Background technique

[0002] Desloratadine is a nonsedating long-acting tricyclic antihistamine. US Patent No. 4,659,716 first described desloratadine in detail. Desloratadine can inhibit the release of various allergic inflammatory mediators by selectively blocking peripheral H1 receptors, such as inhibiting the release of histamine, prostaglandins, interleukins, etc. from mast cells and basophils , to relieve symptoms associated with allergic rhinitis or chronic idiopathic urticaria.

[0003] Desloratadine is the active metabolite of loratadine, a white or off-white solid, slightly soluble in water, easily soluble in ethanol and propylene glycol. Its structure is as follows:

[0004] Desloratadine

[0005] Patent WO02 / 42290 discloses some preparation methods of desloratadine, and discloses...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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