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Huangyangning dispersion tablets and preparation process

A technology of dispersible tablets and buxangine, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve the problem of poor solubility, long disintegration time and slow onset time of cyclovir buxicine D And other issues

Active Publication Date: 2009-08-26
INCREASE PHARMA YINGKOU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Based on the good clinical basis of Huangyangning Tablets and the existing deficiencies, the purpose of the present invention is to provide a new pharmaceutical preparation and its preparation method. The low utilization rate and poor solubility of Cyclovirbuxin D in water and other deficiencies, making it into dispersible tablets with the reputation of solid oral liquid not only greatly increases its solubility, but also can quickly disintegrate in cold water to form Uniform suspension, drink directly, swallow directly or sublingually, convenient to take; at the same time, the surface area is increased, the drug release is fast, and the absorption rate and bioavailability of cyclovirbuxine D are increased, which plays a role Quick and efficient action

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1: Buyang Ning 1g Low-substituted hydroxypropyl cellulose 50g Microcrystalline cellulose 20g Starch 27g Aspartame 2g

[0057] Take Buyang Ning and the auxiliary materials in the prescription and grind them into fine powder respectively, mix them uniformly in the method of equal increase, granulate with 60% ethanol in an appropriate amount, dry, and press into 1000 tablets.

Embodiment 2

[0058] Example 2: Buyang Ning 1g croscarmellose sodium 50g microcrystalline cellulose 20g xylitol 27g stevioside 2g

[0059] Take Buyang Ning and the excipients in the prescription and grind them into fine powders respectively, mix them uniformly in the method of equal increase, granulate with 40% ethanol in an appropriate amount, dry, and press into 1000 tablets.

Embodiment 3

[0060] Example 3: Buyang Ning 1g Cross-linked polyvinylpyrrolidone 50g Microcrystalline cellulose 20g Mannitol 27g Glycyrrhizin 2g

[0061] Take Buyang Ning and the excipients in the prescription and grind them into fine powders respectively, mix them uniformly in the method of equal increase, granulate with 80% ethanol in appropriate amount, dry, and press into 1000 tablets to obtain.

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PUM

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Abstract

The invention relates to a huangyangning dispersible tablet for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. It is mainly prepared from Buyang Ning and appropriate auxiliary materials; the auxiliary materials mainly include disintegrants, fillers and flavoring agents. The dispersible tablet of the present invention has greatly improved solubility in water, and can quickly disintegrate in cold water to form a uniform suspension; it can be taken in various ways, can be directly drunk, or directly swallowed or sublingually contained; it has high bioavailability and good taste. It is easy to be accepted by patients, the process is reasonable and feasible, and the quality is stable and controllable.

Description

technical field [0001] The invention relates to a huangyangning dispersible tablet for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. technical background [0002] Cardiovascular and cerebrovascular diseases have become the number one killer threatening human health, with the characteristics of high morbidity, high mortality, and high disability rate. According to reports, 2.6 million people die from cardiovascular and cerebrovascular diseases in my country every year, and one person dies from such diseases every 12 seconds. Therefore, the prevention and treatment of cardiovascular and cerebrovascular diseases has become an important task for medical experts, scholars and enterprises. A serious and difficult subject. In this tough battle, Cyclovitamin D and its preparations have attracted more and more attention and favor from the world. Modern pharmacological studies ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/57A61K9/20A61P9/00
Inventor 张保献
Owner INCREASE PHARMA YINGKOU CO LTD