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Compositions containing coenzyme Q10

A technology of composition and coenzyme, which is applied in the direction of drug combination, medical preparations containing active ingredients, food science, etc., can solve the problems of high toxicity by-products, poor stability, etc.

Inactive Publication Date: 2009-09-09
TAIYO KAGAKU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the aqueous liquid prepared by the former method is to utilize 1000kg / cm 2 The ultra-high pressure treatment can obtain the aqueous solution of CoQ10 at one time, but the stability is poor, and white turbidity or crystals of CoQ10 will be precipitated over time
In addition, according to the latter method, polyoxyethylene sorbitan monooleate is used, and in view of its production steps, highly toxic by-products are generated in the synthesis reaction of such ethylene oxide-based surfactants, so Not preferred for food use

Method used

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  • Compositions containing coenzyme Q10
  • Compositions containing coenzyme Q10
  • Compositions containing coenzyme Q10

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1

[0106] Add 2.0 g of polyglycerol fatty acid ester (polyglycerol average degree of polymerization 6, HLB=14; trade name "Sunsoft No. Q12F" manufactured by Sun Chemical Co., Ltd.) to 50.0 g of water at 70° C. manufactured by Nichine Medical Instrument Manufacturing Co., Ltd.] for stirring. Then, 5 g of coenzyme Q10 (manufactured by Zhongyuan Chemical Industry Co., Ltd.), polyglycerol condensed ricinoleate (polyglycerol average polymerization degree 5, ricinoleic acid condensation degree = 2. HLB=14, manufactured by Taiyo Chemical Co., Ltd.) 43 g was stirred with PHYSCOTRON to obtain a yellow oil-in-water emulsion type coenzyme Q10-containing composition.

Embodiment 1-2

[0108] Glycerin fatty acid organic ester (organic acid: citric acid, HLB=8.5; trade name "Sunsoft No.623M", manufactured by Sun Chemical Co., Ltd.) 1.2 g, polyglycerol fatty acid ester (polyglycerol average degree of polymerization 6, HLB= 10.5; brand name "Sunsoft No.Q18F", manufactured by Taiyo Chemical Co., Ltd.) 1.5 g was added to 49.3 g of water at 60° C., and stirred with a PHYSCOTRON. Then, 5 g of coenzyme Q10 (manufactured by Zhongyuan Chemical Industry Co., Ltd.), polyglycerol condensed ricinoleate (average degree of polymerization of polyglycerol 5, degree of ricinoleic acid condensation=2 , HLB=16, manufactured by Taiyo Chemical Co., Ltd.) 43 g was stirred with PHYSCOTRON to obtain a yellow oil-in-water emulsion type coenzyme Q10-containing composition. The average emulsified particle diameter of the emulsified particles of coenzyme Q10 in this composition is 20.3 nm.

Embodiment 1-3

[0110] Glycerin fatty acid organic ester (organic acid: citric acid, HLB=9.5; trade name "Sunsoft No. 621B", manufactured by Sun Chemical Co., Ltd.) 10.0 g, polyglycerol fatty acid ester (polyglycerol average degree of polymerization 10, HLB=11 ; brand name "Sunsoft No.Q182S", manufactured by Sun Chemical Co., Ltd.) 14.0 g was added to 883.0 g of water at 60° C., and stirred with an emulsifier (manufactured by TOKUSHU KIKAI KOUGYO CO., LTD.). Then, 50 g of coenzyme Q10 (manufactured by Kanebuchi Chemical Industry Co., Ltd.), polyglycerol condensed ricinoleate (average degree of polymerization of polyglycerol 5, degree of condensation of ricinoleic acid = 2. HLB=18, manufactured by Taiyo Chemical Co., Ltd.) 43.0 g, stirred with an emulsifier, added 1000 g of glycerin, and then stirred with an emulsifier. Then, it was passed through a homogenizer (manufactured by Sanwa Machinery Co., Ltd.) to obtain a yellow oil-in-water emulsion type coenzyme Q10-containing composition. The av...

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Abstract

PROBLEM TO BE SOLVED: To provide a ubidecarenone preparation stably emulsifiable or soluble in water, and usable for food. SOLUTION: This ubidecarenone preparation contains ubidecarenone, a lipophilic polyhydric alcohol fatty acid ester, and a hydrophilic polyhydric alcohol fatty acid ester. It is desirable that the ubidecarenone is obtained through a first process of forming a complex of the ubidekarenone and the lipophilic polyhydric alcohol fatty acid ester, and a second process of mixing the complex obtained through the first process with the hydrophilic polyhydric alcohol fatty acid ester.

Description

technical field [0001] The invention relates to a composition containing coenzyme Q10 which is especially suitable for the food field. Background technique [0002] Coenzyme Q10 (CoQ10) is also called ubidecarenone, ubiquinone-10, etc., and is used as a drug such as a metabolic cardiotonic agent due to its unique physiological action. In addition, domestically, it is possible to use it for food use due to the change in the viewpoint of the distinction between food and medicine, and its application in the field of health food can be expected. Especially in recent years, the research results on CoQ10 have been remarkable. In addition to the cardioprotective effect caused by the antioxidant effect of CoQ10, anti-cancer, anti-aging effects, and inhibition of LDL oxidation in the blood, it is also reported that it can inhibit the increase in blood pressure and improve ischemic myocardium. Oxygen utilization efficiency, activation of ATP synthesis in myocardial mitochondria, impr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L1/30A23L2/00A23L1/035A61K31/122A61K9/107A61K47/14A61P9/00A61P9/10A61P9/12A61P35/00A61P39/06A23L29/10
Inventor 山口瑠美山口裕章南部宏畅L·R·朱内加山崎长宏
Owner TAIYO KAGAKU CO LTD