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A vagina administration apparatus for animals, and its preparation method and application

A technology for vaginal administration and animal use, which is applied in medical science, veterinary instruments, active ingredients of ketones, etc. It can solve the problems of complex production process, affecting the use surface and clinical efficacy, and reducing costs.

Inactive Publication Date: 2010-05-12
SHANGHAI INST OF PLANNED PARENTHOOD RES +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Looking at the CIDR products currently on the market, from large animals "cattle" to small animals "sheep, fox, mink, etc., various sizes and different drug contents are all drug-containing preparations with silicone rubber as the carrier. Its manufacturing process is complicated, its cost is high, and its rapid drug release effect is not ideal, thus affecting its application surface and clinical efficacy
Another vaginal sponge plug containing progesterone has a 10-20 day release time because it is stored in the vagina with a blocked structure. Although it has achieved clinical efficacy, its blocked structure affects vaginal endocrine excretion of food, leading to ascending infection in many animals
[0004] In the technical field, there is a great need to adopt domestic existing machinery and equipment, and use conventional equipment to manufacture vaginal drug delivery devices for animals with infiltrating base tubes, thereby reducing costs and overcoming the two forearm tips of CIDR products. Tightly compress the inner wall of the vagina, resulting in damage to the inner wall of the vagina or ischemic ulcers, as well as insufficient drug release and other problems that affect the curative effect

Method used

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  • A vagina administration apparatus for animals, and its preparation method and application
  • A vagina administration apparatus for animals, and its preparation method and application
  • A vagina administration apparatus for animals, and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1: Vaginal drug delivery device for large animals (cows, horses)

[0057] Prepared by extruding polypropylene as figure 1 In the bracket shown, the longitudinal arm 1a is cylindrical, with a diameter of 8mm and a height of 120mm. The bottom of the trailing arm is an arc with a diameter range of 2mm.

[0058] The forearms 1b and 1b' are also cylindrical, with a diameter of 5mm and a length of 60mm. A circular protrusion 1c and 1c' with a diameter of 5 mm is formed on the tip of the forearm.

[0059] Prepared by molding as figure 2 Extra soft cap of US Dow Corning SiLastic-382 medical grade silicone rubber shown.

[0060] Such as image 3 and 4 As shown, prepare two silicone rubber foam base tubes with a thickness of 7 mm and a length of 60 mm, and put them on the forearm of the bracket; prepare one silicone rubber foam base tube with a thickness of 7 mm and a length of 120 mm, and put them on the bracket on the trailing arm.

[0061] To prepare liquid fo...

Embodiment 2

[0065] Embodiment 2: The vaginal drug delivery device that small animals (sheep, blue fox) use

[0066] Prepared by extruding polypropylene as figure 1 In the bracket shown, the longitudinal arm 1a is cylindrical, with a diameter of 3.5 mm and a height of 50 mm. The bottom of the trailing arm is an arc with a diameter range of 1 mm.

[0067] The forearms 1b and 1b' are also cylindrical, with a diameter of 3mm and a length of 28mm. A circular protrusion 1c and 1c' with a diameter of 4.5 mm is formed on the tip of the forearm.

[0068] Prepared by molding as figure 2 Extra soft caps made with HTV are shown.

[0069] Such as image 3 and 4 As shown, prepare two silicone rubber foam base tubes with a thickness of 3 mm and a length of 24 mm, and put them on the forearm of the bracket; prepare one silicone rubber foam base tube with a thickness of 4 mm and a length of 50 mm, and put them on the bracket on the trailing arm.

[0070] To prepare liquid formulations of the drug...

Embodiment 3

[0074] Example 3: Vaginal drug delivery device for large animals (cows, horses)

[0075] Except preparing the pharmaceutical preparation as follows, other preparations are carried out as described in Example 1:

[0076] Weigh 2 g of progesterone and add 20 ml of absolute ethanol until dissolved, add dropwise on the sponge tube until it volatilizes, and then dry. Then put extra-soft polymer material caps on the tops of the two forearms.

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Abstract

The invention discloses a vagina drug supplying device for mammal, which comprises the following parts: two front arms (1b) and (1b'), rack (1) of longitude arm (1a), drug-pipe typed sponge pipe (2) on the longitude arm (1a), drug-pipe typed sponge pipe (3) and (3') on the front arm (1b) and (1b'), wherein the end part of front arm (1b) and (1b') possesses flexible macromolecular caps (4) and (4'); or the device is composed of drug-carrying piston, which possesses a through-out hole in the center of piston. The invention is fit for the disease due to insufficient luteohormone, which can be applied in the breeding device for mammal.

Description

(1) Technical field [0001] The invention relates to a vaginal drug delivery device for animals, and also relates to a preparation method and application of the drug delivery device. (2) Background technology [0002] At present, progesterone is usually used clinically for infertility, infertility or miscarriage due to follicular dysplasia caused by the reduction of corpus luteum caused by insufficient progesterone, and the maintenance of pregnancy also depends on the progesterone provided by the corpus luteum or placenta. In the animal kingdom, it has been widely used to induce follicular development and accelerate egg maturation, as a drug before artificial insemination or test-tube embryos, to synchronize estrus in animals, and to increase the reproductive rate of livestock. The local high-dose progesterone is released in the blood circulation of the uterine cavity, which is more conducive to the development of follicles and accelerated egg maturation, improving the succes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61D7/00A61L29/00A61K31/12
Inventor 陈海林邵海浩陈建兴陈良康
Owner SHANGHAI INST OF PLANNED PARENTHOOD RES