Stomach floating tablet of bilobalide and preparation method thereof
A technology of ginkgolide and gastric floating tablet, which is applied in the directions of drug combination, pharmaceutical formula, and non-active ingredient medical preparation, etc. Effect of drug release rate and plasma concentration
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Embodiment 1
[0019] Embodiment 1: Take 100 g of ginkgolides (total lactone content > 70%), 1500 g of alginic acid sugar, and 1500 g of cetyl alcohol, and pass through a 80-mesh sieve respectively; Add a small amount of Tween 80 to make soft material, pass through a 20-mesh sieve to make wet granules, dry the wet granules at 40°C, pass through a 18-mesh sieve for granulation, and add a small amount of stearic acid Magnesium, mixed evenly and compressed into tablets to prepare ginkgolide gastric floating tablets.
Embodiment 2
[0020] Embodiment 2: get Ginkgo biloba B (content > 95%) 10g, carbomer 1.5g, carboxymethyl cellulose (CMC) 3.5g, calcium carbonate 1.5g, sodium lauryl sulfate 0.8g, pass through respectively 80-mesh sieve; mix the raw and auxiliary materials evenly, add a small amount of micro-powdered silica gel, mix evenly, and dry-process direct tableting to obtain ginkgolide gastric floating tablets.
Embodiment 3
[0021] Embodiment 3: get ginkgolide (total lactone content>70%) 100g, hydroxypropyl methylcellulose (HPMC) 15g, sodium bicarbonate 20g, lactose 30g, with 10% polyvinylpyrrolidone (PVP) without The water ethanol solution is used as a binder, and a small amount of Tween 80 is added to make a soft material, which is passed through a 20-mesh sieve to make wet granules. After the wet granules are dried at 50°C, passed through a 18-mesh sieve, a small amount of magnesium stearate is added, and mixed. After pressing into tablets, ginkgolide gastric floating tablets were prepared.
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