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Stomach floating tablet of bilobalide and preparation method thereof

A technology of ginkgolide and gastric floating tablet, which is applied in the directions of drug combination, pharmaceutical formula, and non-active ingredient medical preparation, etc. Effect of drug release rate and plasma concentration

Inactive Publication Date: 2007-08-08
张国清
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a gastric floating tablet of ginkgolides and a preparation method thereof for the above-mentioned deficiencies, which solves the problem of oral administration of ginkgolides (for ginkgolide or ginkgolide B) bioavailability In order to improve the bioavailability of oral administration to give full play to its therapeutic effect, it is convenient for patients to take medication

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: Take 100 g of ginkgolides (total lactone content > 70%), 1500 g of alginic acid sugar, and 1500 g of cetyl alcohol, and pass through a 80-mesh sieve respectively; Add a small amount of Tween 80 to make soft material, pass through a 20-mesh sieve to make wet granules, dry the wet granules at 40°C, pass through a 18-mesh sieve for granulation, and add a small amount of stearic acid Magnesium, mixed evenly and compressed into tablets to prepare ginkgolide gastric floating tablets.

Embodiment 2

[0020] Embodiment 2: get Ginkgo biloba B (content > 95%) 10g, carbomer 1.5g, carboxymethyl cellulose (CMC) 3.5g, calcium carbonate 1.5g, sodium lauryl sulfate 0.8g, pass through respectively 80-mesh sieve; mix the raw and auxiliary materials evenly, add a small amount of micro-powdered silica gel, mix evenly, and dry-process direct tableting to obtain ginkgolide gastric floating tablets.

Embodiment 3

[0021] Embodiment 3: get ginkgolide (total lactone content>70%) 100g, hydroxypropyl methylcellulose (HPMC) 15g, sodium bicarbonate 20g, lactose 30g, with 10% polyvinylpyrrolidone (PVP) without The water ethanol solution is used as a binder, and a small amount of Tween 80 is added to make a soft material, which is passed through a 20-mesh sieve to make wet granules. After the wet granules are dried at 50°C, passed through a 18-mesh sieve, a small amount of magnesium stearate is added, and mixed. After pressing into tablets, ginkgolide gastric floating tablets were prepared.

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PUM

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Abstract

The invention relates to a method for preparing bilobalide tablet, which is characterized in that it is prepared from bilobalide drug as active component and relative findings, wherein, the bilobalide drug can be bilobalide or bilobalide B, and the findings contain hydrophilic gel which can quickly expand in the stomach acid condition and float in gastric; and the tablet has significant slow-release effect. The mass ration between the bilobalide drug and the findings is 1:0.3-30. The bilobalide drug is extracted from ginkgo leaf. And the preparation is characterized in that screening the bilobalide drug and findings via the screen at 80-100 deals to be mixed uniformly and pressed into tablet, or using wetting particle making technique or drying particle technique to press the tablet.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to a gastric floating tablet of ginkgolides and a preparation method thereof. Background technique [0002] With the development of Ginkgo biloba research, it has been proved that the active ingredients of Ginkgo biloba are mainly flavonoids and lactones. Among them, ginkgolides are important components with a special structure and significant pharmacological activity that are only found in Ginkgo biloba, and have not been found in any other plants so far. More importantly, they have unique pharmacological effects and therapeutic value. It has been proved that ginkgolides are strong platelet activating factor (plateletacllvatfactor, PAF) receptor antagonists. The monomers of ginkgolides have similar ring-shaped core structures. Currently, ginkgolide mixtures are generally called ginkgolides, and the purified monomers are named ginkgolide A, ginkgolide...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K9/20A61K47/32A61K47/34A61K47/36A61K47/38A61P9/02A61P9/10A61P17/02A61P37/06A61P37/08
Inventor 王广基张国清
Owner 张国清
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