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Cordate houttuynia eye drops and its preparation method

A technology of eye drops and Houttuynia cordata is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the specific ingredients that cannot be determined for efficacy, and it is difficult to find index ingredients , complex natural medicinal ingredients and other issues, to achieve the effect of improving bioavailability, increasing residence time, and quality control

Active Publication Date: 2010-05-12
SICHUAN SUNNYHOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above reports only illustrate the main components in Houttuynia cordata. Due to the complex components of natural medicinal materials, it is impossible to determine the specific components that exert their medicinal effects. It is difficult to control the quality of the prepared preparations, and it is also difficult to find suitable index components for effective control.

Method used

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  • Cordate houttuynia eye drops and its preparation method
  • Cordate houttuynia eye drops and its preparation method
  • Cordate houttuynia eye drops and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Selection of the drug thickener of the present invention

[0026] a. Preparation of the Houttuynia cordata extract of the present invention: Take 2000g of fresh Houttuynia cordata, perform steam distillation, collect 1000ml of the initial distillate, and then distill, collect 900g of the heavy distillate, add the same amount of water for injection, and then perform redistillation , Collect 900g of fine filtrate;

[0027] b. Choose thickener:

[0028] Commonly used thickeners are: chitosan, hypromellose, sodium hyaluronate, carbomer, polyvinyl alcohol. Now choose the above thickening and selection. Firstly, the water solubility is screened separately.

[0029] Thickener

Dissolution conditions

result

Chitosan

Take 0.3g of this product and add 100ml

Water for injection

Colorless transparent liquid

Hypromellose

Take 0.3g of this product and add 100ml

Water for injection

It swells completely in 2~3 days and is colorless

Clear liquid ...

Embodiment 2

[0042] Example 2 Preparation of drug eye drops of the present invention

[0043] Weigh the amount of raw materials and auxiliary materials:

[0044] Houttuynia cordata extract 1000g

[0045] Chitosan 3g

[0046] Span 20 1g

[0047] Sodium chloride 7g

[0048] Benzalkonium chloride 0.01g

[0049] Make 1000ml

[0050] Preparation method: Take 5000g of fresh Houttuynia cordata, perform steam distillation, collect 3000ml of initial distillate, and then distill, collect 1000g of heavy distillate, add the same amount of water for injection, then perform redistillation, collect 1000g of fine filtrate, add shell Glycan 3g, sodium chloride 7g, span 201g, benzalkonium chloride 0.01g, stir to dissolve, add water for injection to 1000ml, adjust the pH to 4.5-7.5, filter, potting, and get it.

Embodiment 3

[0051] Example 3 Preparation of the drug eye drops of the present invention

[0052] Weigh the amount of raw materials and auxiliary materials:

[0053] Houttuynia cordata extract 600g

[0054] Hydroxyethyl cellulose 0.5g

[0055] Tween 80 5g

[0056] Sodium chloride 7g

[0057] Benzalkonium bromide 1g

[0058] Make 1000ml

[0059] Preparation method: take 0.5g of hydroxyethyl cellulose, add 300ml of water for injection to make it swell naturally, filter, and reserve; take 4000g of fresh houttuynia cordata, perform steam distillation, collect 2000ml of first distillate, then perform distillation, collect weight Distillate 1000ml, add the same amount of water for injection, then redistill, collect 600g of fine filtrate, then add 7g of sodium chloride, 805g of Tween, and 1g of benzalkonium bromide, stir to dissolve, mix with hydroxyethylcellulose solution, Add water for injection to 1000ml, adjust pH to 4.5-7.5, filter, potting, and get ready.

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Abstract

The invention relates to houttuynia cordata eye drops, which uses the houttuynia cordata extractive as active components, added with medical acceptable eye findings, wherein, the houttuynia cordata extractive contains 1.0mug-5.0mug / ml methyl nonyl ketone. The invention also provides relative preparation, while the drug quality is stable. And the methyl nonyl ketone is selected as the index component with controllable quality.

Description

Technical field [0001] The invention relates to an eye drop, which is prepared from houttuynia cordata as a raw material and belongs to the field of medicine. Background technique [0002] After the traditional eye drops are administered, due to the rapid blinking of the eyelids and the continuous secretion of tears in the conjunctival sac, the eye drops are quickly eliminated through the nasolacrimal duct, resulting in low bioavailability of eye drops (often less than 1 %). To achieve the therapeutic effect, frequent administration is required. Although eye ointment prolongs the residence time, it has its unavoidable defects, such as blurred vision caused by eye ointment, which brings inconvenience to users. The disadvantage of the original formulation is that about 95% of the administered dose does not enter the eye tissues, but is absorbed through the nasolacrimal duct system and the nasal / gastric mucosa. [0003] The current reports on houttuynia cordata ophthalmic preparati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/78A61K9/08A61K47/38A61P27/02A61K31/121
Inventor 郭成辉杨用祥
Owner SICHUAN SUNNYHOPE PHARM CO LTD