Toad sterene compounds and application thereof in pharmaceutical preparation

Abstract

The invention discloses a 3-epi-bufalin 3-O-beta-D-glucoside and derivant, which inhibits cancer cell from growing rather than bufalin to make cardiotonic, local anesthesia, combat shock and tumour-resistant drug.

Description

technical field

[0001] The invention belongs to the technical field of medicinal chemistry and its preparation, and specifically relates to a class of steroid compounds. Background technique

[0002] Bufasterene is a class of steroidal compounds in which the C-17 position is linked to a six-membered unsaturated lactone ring (α-pyrone ring). Natural bufasterene A / B rings are cis or trans fused, and B / C rings are all trans, but unlike general steroids, its C / D rings are cis fused. In addition to most of the hydroxyl groups at the C-3 position, bufasterene often has oxygen-containing substitutions at the 5β-, 6β-, 11α-, 12α- / β-, 14β-, 16β- and 19-positions (mostly hydroxyl or acetoxy group), and some form a three-membered oxygen ring at the 14β, 15β-position. Some 19-positions are oxidized to aldehyde groups, and some C-19 is absent. Δ4,5 is the most common double bond in the molecule, and there are also Δ14,15, Δ3,4 and Δ6,7, etc. Some of C-12 are substituted by carbonyl, ...

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