Enticawer release-controllable tablet and its preparation
A technology of entecavir and controlled-release tablets, which is applied in the field of medicine and its preparation, can solve the problems of blood drug concentration peak and valley, fast drug absorption, short half-life, etc., and achieve peak-valley avoidance, stable blood concentration, and high drug efficacy Effect
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Embodiment 1
[0024] Entecavir Controlled Release Tablets
[0025] 1. Tablet core composition:
[0026] Name of raw material
[0027] Entecavir 1%
[0028] Lactose 46%
[0029] Starch 35%
[0030] Hypromellose 4%
[0032] Talc 4%
[0033] 2. Membrane controlled release coating composition:
[0034] Ethylcellulose 5%
[0035] Methylcellulose 3%
[0036] Glycerin 1%
[0037] Preparation:
[0038] 1. According to the above formula amount, crush entecavir and filler, sieve and mix them evenly, make soft material with binder, granulate, granulate after drying, add lubricant and glidant and mix evenly, and press into tablet core.
[0039] 2. Prepare the controlled-release coating solution according to the above-mentioned film controlled-release coating composition prescription, put the prepared tablet cores in the coating pan, and coat with the coating solution.
[0040] 3. Drying, product packaging.
Embodiment 2
[0042] Entecavir Controlled Release Tablets
[0043] 1. Tablet core composition:
[0044] Name of raw material
[0045] Entecavir 1%
[0046] Microcrystalline Cellulose 46%
[0047] Starch 28%
[0048] Polyvinylpyrrolidone 5%
[0049] Polyethylene glycol 4%
[0050] Talc 6%
[0051] 2. Membrane controlled release coating composition:
[0052] Cellulose acetate 5%
[0053] Hypromellose 4%
[0054] Diethyl phthalate 1%
[0055] Preparation:
[0056] 1. According to the above formula amount, crush entecavir and filler, sieve and mix them evenly, make soft material with binder, granulate, granulate after drying, add lubricant and glidant and mix evenly, and press into tablet core.
[0057] 2. Prepare the controlled-release coating solution according to the above-mentioned film controlled-release coating composition prescription, put the prepared tablet cores in the coating pan, and coat with the coating solution.
[0058] 3. Drying, product packaging.
[0059] ...
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