Wound closing device containing erucic acid
A closed device, erucic acid technology, applied in medical science, surgery, etc., can solve the problems of sticking and death that cannot be pulled open, increase patient pain, needles and threads are easy to enter the wound by mistake, etc., to inhibit the invasion of bacteria and avoid infection and inflammation. , the effect of reducing blood extravasation
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Embodiment 1
[0036] Heat and melt 50 g of erucic acid and mix it with 0.5 g of tea tree oil, add 20 g of glycerin, 20 g of zinc oxide and 10 g of starch, grind it into an ointment, make an anti-adhesion protective agent, and apply it to the support pad (9) and the support belt (1 ) inside, made of anti-blocking protective agent coating.
[0037] As shown in Figures 1 and 2, the present invention includes a zipper (5) composed of a fitted tooth row (2) placed on the support belt (1) and a zipper puller (3). The excretory opening (6), the two ends of the zipper (5) have pull-ring belts (4), the two sides of the support belt (1) are connected with the flexible connecting belt (7) and the support pad (9) through double-sided adhesive, and the skin adhesive belt (8) sticky strip (10) is pasted below, and the inboard of support pad (9) and support band (1) is coated with the anti-adhesion protective agent coating (12) that contains erucic acid substance. The zipper (5) of the present invention ...
Embodiment 2
[0042] Except that the formula of the anti-adhesion protective agent is modified to: 54g of erucic acid, 0.4g of tea tree oil, 15g of glycerin, 10g of zinc oxide and 17g of starch, the others are the same as in Example 1.
Embodiment 3
[0044] Except that the formula of the anti-adhesion protective agent is modified to: erucic acid 46g, tea tree oil 0.8g, glycerin 24g, zinc oxide 15g and starch 20g, others are the same as Example 1.
[0045] Biocompatibility studies
[0046]In this study, according to the use of medical zippers, the skin irritation test was carried out to evaluate its biocompatibility with reference to the national standard medical device biological evaluation.
[0047] 1 Experimental materials
[0048] The medical zipper obtained in embodiment 1
[0049] 20 ordinary grade New Zealand rabbits were provided by the Experimental Animal Center of China Pharmaceutical University. Feed full-price nutritious pellet feed, eat food at will, drink water constantly, and maintain good cleanliness and sanitation.
[0050] 2 Skin irritation test method
[0051] Adult healthy New Zealand rabbits, both male and female, weighing 1.5-2.5kg, the skin of the animal is depilated 24 hours before administration...
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