Application of salvia miltiorrhiza bge I sodium sulfonate in the preparation of medicine and its medicine made by the same

A technology of sodium sulfonate and tanshinone, applied in the application of tanshinone 1 sodium sulfonate in pharmacy, and the pharmaceutical field with tanshinone 1 sodium sulfonate as a component, can solve problems such as tanshinone 1 sodium sulfonate not being effectively utilized and the like

Active Publication Date: 2007-09-19
NANJING HEALTHNICE MEDICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The present invention aims at the current problem that sodium tanshinone I sulfonate is only used as an impurity and has not been effectively u

Method used

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  • Application of salvia miltiorrhiza bge I sodium sulfonate in the preparation of medicine and its medicine made by the same
  • Application of salvia miltiorrhiza bge I sodium sulfonate in the preparation of medicine and its medicine made by the same
  • Application of salvia miltiorrhiza bge I sodium sulfonate in the preparation of medicine and its medicine made by the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0129] Synthesis and Structure Confirmation of Sodium Tanshinone I Sulfonate

[0130] 1) Synthesis: Get 0.2 gram of Tanshinone I and drop into a three-necked bottle filled with 5.2ml of glacial acetic acid and 7.2ml of acetic anhydride, add dropwise 0.4ml of concentrated sulfuric acid-glacial acetic acid (V:V=1:1) under ice-water bath, Stir at room temperature for 4 hours, slowly add 20ml of saturated NaCl solution, stir for 0.5 hours, filter with suction, wash the filter cake with saturated NaCl solution (10ml, twice), wash the filter cake with water, make the filter cake ) and dried under reduced pressure. Take the filter cake and add 200ml of ethyl acetate to reflux for 6 hours, remove unsulfonated fat-soluble impurities, filter, take the solid matter and dissolve it in 400ml of absolute ethanol, reflux for 4 hours, filter, take the filtrate, remove the solvent under reduced pressure, and obtain reddish-brown The solid was recrystallized from methanol to obtain the target ...

Embodiment 2

[0136] Synthesis and Structure Confirmation of Sodium Tanshinone I Sulfonate

[0137] 1), Synthesis: Take 5g of Tanshinone I raw material, add 13ml of glacial acetic acid, then add 20ml of acetic anhydride, place in a three-necked flask, add 10ml of concentrated sulfuric acid-glacial acetic acid (1:1) dropwise at 10-15°C under stirring After the dropwise addition, stir at room temperature for 1 hour, then slowly pour the reaction solution into an equal volume of distilled water, and quickly add 100ml of saturated aqueous sodium chloride solution, that is, thick sodium tanshinone I sulfonate is precipitated, centrifuged , the precipitate was washed twice with saturated sodium chloride solution, and then washed once with an appropriate amount of water to make the solid matter pH=5-6, and the solid matter was evaporated to dryness on a water bath to obtain 6.1 g of brown-red sodium tanshinone Isulfonate crude product , Yield: 80.8%. Dissolve the crude sodium tanshinone I sulfona...

Embodiment 3

[0142] Preparation of Sodium Tanshinone I Sulfonate Lyophilized Powder for Injection

[0143] Take 4g of sodium tanshinone I sulfonate and 40g of mannitol, add water for injection to 2000ml (1000 counts), stir and heat to 60°C to dissolve, use 0.2% (w / v) activated carbon for needles, decarbonize by coarse filtration, and use 0.22um microporous membrane fine filtration, detection of intermediate content, filling 2ml / bottle, semi-pressed butyl rubber stopper, freeze-drying to obtain tanshinone sodium sulfonate freeze-dried powder injection.

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Abstract

Application of tanshinone I sulfonic sodium for preparing drug and the drug produced thereby are disclosed in the invention, which belongs to a novel use art of the tanshinone I sulfonic sodium. Generally, the tanshinone I sulfonic sodium is an impurity of the tanshinone II sulfonic sodium and is already known as functions of resisting bacteria and eliminating inflammation and the like. The invention provides that the tanshinone I sulfonic sodium can be adapted to prepare drug for treating coronary heart disease, or anti-cancer drugs, capable of producing various formulation drugs used by per os or injection. In addition, new function of the tanshinone I sulfonic sodium is developed, which is safe, effective, has strong pharmacological action and excellent prospect in medicine.

Description

technical field [0001] The present invention relates to the application of a kind of compound in pharmacy, more specifically, the present invention relates to the application of tanshinone I sulfonate sodium in pharmacy and the medicament with tanshinone I sulfonate as component. Background technique [0002] Salvia miltiorrhiza is a commonly used traditional Chinese medicine with the effect of promoting blood circulation and removing blood stasis. It is the dry root and rhizome of salviamiltiorrhiza Bge. Bitter in the mouth, slightly cold in nature, Guixin and Liver meridians. It has the effects of dispelling blood stasis and relieving pain, promoting blood circulation and promoting menstrual flow, clearing heart and eliminating troubles. It is used for irregular menstruation, amenorrhea, dysmenorrhea, accumulation of lumps in the abdomen, tingling pain in the chest and abdomen, heat arthralgia pain, sore swelling and pain, upset and insomnia, hepatosplenomegaly, angina pe...

Claims

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Application Information

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IPC IPC(8): A61K31/343A61K9/08A61K9/19A61K9/20A61K9/48A61K9/50A61P9/10A61P9/06A61P35/00
Inventor 邹巧根
Owner NANJING HEALTHNICE MEDICAL TECH
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