Substitute 2,3-dihydrogen thiazole [4,5-d] pyrimidine-7(6H)- ketone (imines) having weed removal active and preparation thereof

Abstract

The invention discloses a multi-substituted-2, 3-dihydro-thiazole-[4, 5-d] pyrimidine-7(6H)-ketone (imine), wherein Y is O and NH; R1 is phenyl or substituted phenyl, which is halogen on the phenyl with substituted group at random position of phenyl ring to do the same or different single substitution or multiple substitutions; R2 is H, C1-C6 monoalkyl amino, C1-C6 dialkyl amino, phenyl amine, phenyl alkyl (C1-C4) amino or substituted pridefine (C1-C4) amino, heterocyclic substituted C1-C4 alkyl amino of furan, piperidine and morphia; R3 is C1-C8 alkyl, phenyl or substituted phenyl, pridefine (C1-C4) or substituted pridefine (C1-C4); the substituted group on the phenyl of R2 and R3 is halogen, C1-C6 alkyl or alkoxy, which can be the same or different.

Description

technical field [0001] The present invention relates to the preparation method of multi-substituted 2,3-dihydrothiazolo[4,5-d]pyrimidin-7(6H)-one (imine) compound and its intermediate with herbicidal activity, and its use as herbicide biological activity. Background technique [0002] Thiazolopyrimidine is an important analogue of purine, and its remarkable biological activity is attracting more and more attention. Pharmacological studies have confirmed that 7-thia-8-oxoguanosine (7-thia-8-oxoguanosine) has an inhibitory effect on various viral infections in organisms, and has entered the clinical trial stage as an immunotherapy drug for viral infections; Lewis et al. Studies have proved that these compounds have a good inhibitory effect on human HCMV virus. In addition, a large number of studies have shown that these compounds have good chemotherapeutic effects in terms of sterilization, anti-tumor, sedation, and rheumatism. In plant protection, the microbicidal and inse...

AI Technical Summary

Problems solved by technology

[0008] At present, there are relatively few reports on the synthesis of thiazolo[4,5-d]pyrimidine compounds. There are two main routes to synthesize such compounds. One is to synthesize the corresponding pyrimidine ring from the thiazole ring through ring-closing reaction, The second is to start from the pyrimidine ring and synthesize the thiazole ring through corresponding ring closure to obtain pyridopyrimidine compounds. The conditions required by these methods are relatively harsh, the reaction time is long, and there are many steps.

[0009] The biological activity of thiazolo[4,5-d]pyrimidines is mainly limited to pharmacological activity, and there are few reports on its pesticide activity.

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